Pathogenic bacterial profile and drug resistance analysis of community-acquired pneumonia in older outpatients with fever

Luan, Ying; Sun, Yuling; Duan, Shuhong; Zhao, Ping; Bao, Zhongying

doi:10.1177/0300060518786915

Cited by 23 publications

(38 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Vaccination either excites or reinforces the immune competence of a host to ward off infection, leading to the activation of macrophages, the production of antibodies, inflammation, and other classic immune reactions. 40 Antibacterial vaccines have been responsible for a drastic reduction in global bacterial diseases. Vaccines made from attenuated whole cells or lysates have been replaced largely by less erectogenic, cell-free vaccines consisting of purified components, including capsular polysaccharides and their conjugates, to protein carriers, as well as inactivated toxins (toxoids) and proteins.…”

Section: Vaccinesmentioning

confidence: 99%

Review on a Potential of Antibiotics

Singh

Verma

Kumar

et al. 2018

J. Drug Delivery Ther.

View full text Add to dashboard Cite

Observations about the growth of some microorganisms inhibiting the growth of other microorganisms have been reported since the late 1800s. These observations of antibiosis between microorganisms led to the discovery of natural antibacterial. This paper deliberates important findings of the educations conducted by numerous national and international combined organizations on a brief indication of the antibacterial agents׳ detection in recent years. In India especially the developing antibiotics, need to institute methods for the suitable choice of drug conduct a compound problem involving prescribers, dispensers, and consumers. Keywords: Antibiotic, Antibiotic resistance, bacterial Infection

show abstract

Section: Vaccinesmentioning

confidence: 99%

Review on a Potential of Antibiotics

Singh

Verma

Kumar

et al. 2018

J. Drug Delivery Ther.

View full text Add to dashboard Cite

show abstract

“…We summarized the baseline characteristics of the included studies in Table 1 . The 21 eligible articles involved 7,650 patients and 1,360 MDR organisms, of which ten reported the risk factors for MDR GPB and GNB [ 15 , 19 , 26 , 28 , 31 , 33 , 34 , 38 , 39 , 41 ], ten for MDR GNB [ 14 , 16 , 17 , 27 , 29 , 30 , 32 , 35 , 36 , 40 ], and one for MDR GPB [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

“…The risk of bias of the included articles is listed in Table 2 . The overall risk of bias of 15 articles [ 14 – 17 , 19 , 27 , 29 – 31 , 33 , 35 , 36 , 38 , 39 , 41 ] is rated as low, four [ 26 , 34 , 37 , 40 ] as moderate, and two [ 28 , 32 ] as high, indicating that most of the included studies had intermediate or higher quality.…”

Section: Resultsmentioning

confidence: 99%

“…Prior antibiotic treatment is the most frequently reported risk factor that is correlated with the acquisition of MDR bacteria [ 14 – 16 , 19 , 26 , 28 , 30 , 34 , 36 – 38 , 41 ]. Six of the included studies [ 14 , 19 , 30 , 36 , 38 , 41 ] defined prior antibiotic treatment as the antibiotic use within 30 days before admission, while another two studies [ 15 , 26 ] as 90 days before diagnosis and one study [ 16 ] as 12 months before diagnosis.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Risk Factors of Multidrug-Resistant Bacteria in Lower Respiratory Tract Infections: A Systematic Review and Meta-Analysis

Chen

Sun

et al. 2020

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

Background. Multidrug-resistant (MDR) bacteria are the main cause of lower respiratory tract infections (LRTIs) with high mortality. The purpose of this study is to identify the risk factors associated with MDR by performing a systematic review and meta-analysis. Methods. PubMed, EMBASE (via Ovid), and Cochrane Library were systematically searched for studies on the risk factors for MDR bacteria in LRTIs as of November 30, 2019. Literature screening, data abstraction, and quality assessment of the eligible studies were performed independently by two researchers. Results. A total of 3,607 articles were retrieved, of which 21 articles representing 20 cohort studies published in English were included after title/abstract and full-text screening. Among the 21 articles involving 7,650 patients and 1,360 MDR organisms, ten reported the risk factors for MDR Gram-positive bacteria (GPB) and Gram-negative bacteria (GNB), ten for MDR GNB, and one for MDR GPB. The meta-analysis results suggested that prior antibiotic treatment, inappropriate antibiotic therapy, chronic lung disease, chronic liver disease and cerebral disease, prior MDR and PA infection/colonization, recent hospitalization, longer hospitalization stay, endotracheal tracheostomy and mechanical ventilation, tube feeding, nursing home residence, and higher disease severity score were independent risk factors for MDR bacteria. Conclusions. This review identified fourteen clinical factors that might increase the risk of MDR bacteria in patients with LRTIs. Clinicians could take into account these factors when selecting antibiotics for patients and determine whether coverage for MDR bacteria is required. More well-designed studies are needed to confirm the various risk factors for MDR bacteria in the future.

show abstract

“…At present, the situation of bacterial resistance is severe. Luan's study [16] showed that approximately 30% of P. aeruginosa was resistant when older outpatients were infected with community-acquired pneumonia. In a study by Fink et al [17], monotherapy with 400 mg of ciprofloxacin administered every 8 h resulted in 33% resistance to hospital acquired pseudomonas pneumonia, whilst 500 mg of imipenem given every 6 h or 1000 mg every 8 h resulted in 50% resistance.…”

Section: Discussionmentioning

confidence: 99%

Levofloxacin-ceftazidime administration regimens combat Pseudomonas aeruginosa in the hollow-fiber infection model simulating abnormal renal function in critically ill patients

Jian

2020

BMC Pharmacol Toxicol

View full text Add to dashboard Cite

Background: The purpose of this study was to investigate the bactericidal effects of levofloxacin and ceftazidime as both monotherapy and combination therapy, and to determine their effects on resistance suppression in patients with normal and abnormal (Ccr:16-20 mL/min) renal function. Common clinical administration regimens to provide reference values were further evaluated. Methods: The 7-d hollow-fiber infection model was used to inject the Pseudomonas aeruginosa standard strain (ATCC27853), which simulated common clinical administration regimens for patients with different renal function. Ten regimens were stratified into 2 categories based on renal function, and each category contained 3 monotherapy regimens and 2 combination therapy regimens. Total and resistant populations were quantified. Drug concentrations were determined by high-performance liquid chromatography (HPLC). Results: Monotherapy regimens resulted in about 0.5-log-CFU/mL bacterial kill in the total population at 6 or 8 h, whilst combination regimens resulted in 2-to 3-log-CFU/mL within 2 days. For levofloxacin monotherapy regimens in patients with normal renal function, resistance emergence was seen after 6 h, and was seen at 0 h in the ceftazidime monotherapy regimen, as well as in all regimens of patients with abnormal renal function. Although resistant subpopulation in combination regimens with abnormal renal function began to increase at 0 h, there was a definite downward trend after 8 h, while resistant population in the normal renal function group increased after 16 h. Conclusions: Combination therapy had greater bactericidal efficacy and resistance inhibition compared with monotherapy. Studying combination regimens in randomized clinical trials is warranted.

show abstract

Pathogenic bacterial profile and drug resistance analysis of community-acquired pneumonia in older outpatients with fever

Cited by 23 publications

References 17 publications

Review on a Potential of Antibiotics

Review on a Potential of Antibiotics

Risk Factors of Multidrug-Resistant Bacteria in Lower Respiratory Tract Infections: A Systematic Review and Meta-Analysis

Levofloxacin-ceftazidime administration regimens combat Pseudomonas aeruginosa in the hollow-fiber infection model simulating abnormal renal function in critically ill patients

Contact Info

Product

Resources

About