Pathogenic Differences Between Various Feline Coronavirus Isolates

Pedersen, Niels C; Black, John W.; Boyle, John; Evermann, James F.; McKeirnan, A. J.; Ott, Richard L.

doi:10.1007/978-1-4615-9373-7_36

Cited by 116 publications

(143 citation statements)

References 13 publications

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“…8 The first reason for the discrepancy could be the predominance of different serotypes of FCoV (serotype I versus serotype II). 3 In Japan, 30% of cats having FIP are infected with serotype II, 15 whereas in Europe, only 14% harbor serotype II. 16 The prognosis might be better in cats infected with serotype II.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Feline Interferon‐Omega on the Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis

Ritz

Egberink

Hartmann

2007

Veterinary Internal Medicne

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Background: There is no therapy with proven efficacy to treat cats with feline infectious peritonitis (FIP). Hypothesis: Feline interferon‐omega (FeIFN‐ω) prolongs survival time and increases quality of life in cats with FIP. Animals: Thirty‐seven privately owned cats were subjects of this study. Methods: The study was performed as a placebo‐controlled double‐blind trial. Feline infectious peritonitis was confirmed by histology or immunostaining of feline coronavirus (FCoV) antigen in effusion or tissue macrophages or both. The cats were randomly selected for treatment with either FeIFN‐to or a placebo. All cats received adjunctive treatment with glucocorticoids and antibiotics and passive immunization with Feliserin. Results: There was no statistically significant difference in the survival time of cats treated with FeIFN‐ω versus placebo or in any other variable evaluated (with the exception of the lymphocyte count). The cats survived between 3 and 200 days (median, 9 days). There was only 1 long‐term survivor (>3 months), and the cat was in the FeIFN‐ω group. Conclusion and Clinical Relevance: No effect of FeIFN‐ω on survival time or quality of life could be demonstrated in this study.

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Section: Discussionmentioning

confidence: 99%

“…1 It is an immune-mediated disease that is triggered by infection with a feline coronavirus (FCoV). 2 FCoV exists in 2 serotypes (serotype I and II), 3 which differ in growing behavior and cell cytotoxicity in vitro but not in their potential to cause FIP. 4 FIP is a deadly disease, and there are no confirmed reports of cats that have recovered from it.…”

mentioning

confidence: 99%

Effect of Feline Interferon‐Omega on the Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis

Ritz

Egberink

Hartmann

2007

Veterinary Internal Medicne

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“…However, the FIPV UCD-1 strain used in their study proliferates well in CrFK cells, and is antigenically similar to type II FCoVs, CCV and TGEV [4,21]. These properties are different from those of the original UCD-1 strain [12,23]. Recently, de Groot and Horzinek [5] indicated the possibility of virus stocks may have been interchanged.…”

Section: Ade Of Fipv Strain 79-1146 Infection In Human Monocyte Cell mentioning

confidence: 99%

“…Feline coronaviruses (FCoVs) are divided into FIPV types I and II, and feline enteric coronavirus types I and II [23]. The type II strains appeared to be more closely related to canine coronavirus (CCV) and transmissible gastroenteritis virus (TGEV), since immunodominant neutralization epitopes shared by the spike proteins of TGEV, CCV, and the type II FCoV strains seemed to be absent in the type I strains [12].…”

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confidence: 99%

Antibody-Dependent Enhancement of Feline Infectious Peritonitis Virus Infection in Feline Alveolar Macrophages and Human Monocyte Cell Line U937 by Serum of Cats Experimentally or Naturally Infected with Feline Coronavirus.

et al. 1998

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ABSTRACT. Infection of the type II feline infectious peritonitis virus (FIPV) strain 79-1146 to primary feline alveolar macrophages and human monocyte cell line U937 was enhanced by the sera of cats experimentally infected with the 79-1146 strain, but not those of cats infected with KU-2 or UCD-1 strain of type I FIPV. The experiments using sera of cats with feline infectious peritonitis (FIP) and of cats naturally infected with feline coronavirus (FCoV) revealed that infection of the FIPV 79-1146 strain to the U937 cells was enhanced only by the sera of cats infected with type II FIPV or feline enteric coronavirus. The samples positive for antibody-dependent enhancement (ADE) activity had high neutralizing antibody titers against the FIPV 79-1146 strain and the samples negative for ADE activity had low neutralizing antibody titers. These findings support the previous results where a monoclonal antibody with neutralizing activity had high ADE activity, suggesting that there was a close relationship between the neutralization and enhancement sites. And then it is also suggested that ADE of infection is likely to be induced by re-infection with the same serotype of virus in type II FIPV infection. Furthermore, U937 cells are considered useful and can be substituted for the feline macrophages for determining ADE of FIPV-infection. -KEY WORDS: antibody-dependent enhancement of infection, feline infectious peritonitis virus, feline macrophage, U937 cell.

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“…Ακολουθεί δευτερογενής ιαιμία κατά την οποία ο κοροναϊός συνδε δεμένος πλέον με τα μακροφάγα μεταφέρεται σε πολλά άλλα σημεία, όπως στους ορογόνους υμένες των κοιλια κών οργάνων, το νευρικό σύστημα και τους οφθαλμούς 1,2 . Τα αγγειοπαθογόνα στελέχη προσβάλλουν λοιπόν και στόχους πέρα από το έντερο, σε αντίθεση με τα εντερο παθογόνα στελέχη, που περιορίζονται στο έντερο όπου προσβάλλουν τα εντερικά κύτταρα 18 .…”

Section: παθογένειαunclassified

Feline Coronavirus infections and feline infectious peritonitis

Tzivara

Kritas

2018

J Hellenic Vet Med Soc

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Cats are susceptible to infection with several different strains of feline Coronavirus. Depending on the involved strain, clinical signs may range from asymptomatic infection to gastrointestinal disease or fibrinous serositis and disseminated vasculitis, commonly known as feline infectious peritonitis (FIP). Excretion of virus by infected cats into the environment occurs by faeces, oronasal secretions and urine. The feline coronaviruses are rapidly inactivated by most disinfectants. Clinical diagnosis of Coronavirus infection is made by evaluating the case history, physical findings, laboratory results, Coronavirus antibody titers and tissue biopsy. A temperature-sensitive feline infectious peritonitis virus vaccine has become available for healthy 16 week of age or older cats.

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Pathogenic Differences Between Various Feline Coronavirus Isolates

Cited by 116 publications

References 13 publications

Effect of Feline Interferon‐Omega on the Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis

Effect of Feline Interferon‐Omega on the Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis

Antibody-Dependent Enhancement of Feline Infectious Peritonitis Virus Infection in Feline Alveolar Macrophages and Human Monocyte Cell Line U937 by Serum of Cats Experimentally or Naturally Infected with Feline Coronavirus.

Feline Coronavirus infections and feline infectious peritonitis

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