Pathogenic mechanisms in endometriosis-associated infertility

Gupta, Sajal; Goldberg, Jeffrey M.; Aziz, Nabil; Goldberg, Eric; Krajcir, Natalie; Agarwal, Ashok

doi:10.1016/j.fertnstert.2008.02.093

Cited by 362 publications

(321 citation statements)

References 99 publications

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“…In addition, some investigators have suggested that the dominance of proinflammatory cytokines in peritoneal and tubal fluid in women with endometriosis may have an adverse effect on oocyte quality and/or embryo development [88,89]. At a clinical level, this hypothesis is further supported by studies demonstrating a decreased pregnancy rates when IVF-ET treatment is performed using donated oocytes obtained from women with endometriosis as compared to when oocyte donors did not have endometriosis [90].…”

Section: Endometriosismentioning

confidence: 99%

Tubal transport of gametes and embryos: a review of physiology and pathophysiology

Ezzati

Djahanbakhch

Arian³

et al. 2014

J Assist Reprod Genet

106

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With the advent of assisted reproductive technology in the past three decades, the clinical importance of fallopian tubes has been relatively overlooked. However, successful spontaneous conception requires normal function of the tube to provide not only a conduit for the gametes to convene and embryo to reach the uterine cavity, but also a physiologically optimized environment for fertilization and early embryonic development. In this review, after a brief description of normal human tubal anatomy and histology, we will discuss tubal transport and its principal effectors, including ciliary motion, muscular contractility and tubal fluid. Furthermore, we will discuss the ciliary ultrastructure and regulation of ciliary beat frequency by ovarian steroids, follicular fluid, angiotensin system, autonomic nervous system and other factors such as adrenomedullin and prostaglandins. In the last section, we describe the adverse impact of various pathological conditions, such as endometriosis, infection and smoking on tubal function and ciliary motility.

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Section: Endometriosismentioning

confidence: 99%

Tubal transport of gametes and embryos: a review of physiology and pathophysiology

Ezzati

Djahanbakhch

Arian³

et al. 2014

J Assist Reprod Genet

106

View full text Add to dashboard Cite

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“…It has been shown that endometriosis alters the composition of the peritoneal fluid deregulating a number of immunologic factors and increasing the level of reactive oxygen species. These changes may alter folliculogenesis and lead to poorer quality oocytes with reduced fertilization rates and poorer embryonic development and implantation [1]. Peritoneal fluid from women with endometriosis may also affect tubal ciliary activity which in combination with anatomical distortion combine to reduce pickup of the ovum [3].…”

Section: Impact Of Endometriosis On Fertilitymentioning

confidence: 99%

“…Women diagnosed with endometriosis have one third of the monthly fecundity rate of the general population ranging between 2 and 10 % per month [1]. Even within a population of subfertile women, endometriosis may reduce the chance of spontaneous conception further compared to women with unexplained infertility [2].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Endometriosis in Women Desiring Fertility

Mavrelos

Sarıdoğan

2015

J Obstet Gynecol India

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Endometriosis is a common condition affecting a significant proportion of women in their reproductive age. Apart from the impact of endometriosis on the quality of life of these patients, it also can have an impact on the potential of these women to have a family. The options for treating women with endometriosis desiring a family include surgery or assisted reproduction techniques. The choice of treatment will depend on the stage of disease and the characteristics of the couple seeking help. We review here the latest evidence on the management of endometriosis in women desiring fertility and describe our current practice.

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“…The association of endometriosis with infertility is proven; however, the mechanisms by which endometriosis affects reproductive function remain as a debatable issue [3]. The impact of endometriosis on fertility and fecundity was obtained from the studies conducted on ovarian cells such as granulosa and Cumulus cells, endometrial profiling, follicular microenvironment, and outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ Capsule These epigenetic changes along with differential binding of ERβ (as a transcription factor) in CYP19A1 promoters may impair follicular steroidogenesis, leading to poor Oocyte and embryo condition in endometriosis patients.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic alterations of CYP19A1 gene in Cumulus cells and its relevance to infertility in endometriosis

Hosseini

Mehraein

Shahhoseini

et al. 2016

J Assist Reprod Genet

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Purpose The purpose of the present study was to investigate the epigenetic mechanisms responsible for the aberrant aromatase expression (CYP19A1) in Cumulus Cells (CCs) of infertile endometriosis patients. Method Cumulus cells were obtained from 24 infertile patients with and without endometriosis who underwent ovarian stimulation for intracytoplasmic sperm injection. Expression of CYP19A1 gene was quantified using Reverse Transcription Q-PCR. DNA methylation, histone modifications, and binding of Estrogen Receptor, ERβ to regulatory DNA sequences of CYP19A1 gene were evaluated by Chromatin ImmunoPrecipitation (ChIP) assay.Results CYP19A1 gene expression in CCs of endometriosis patients was significantly lower than the control group (P = 0.04). Higher incorporation of MeCP2 (as a marker of DNA methylation) on PII and PI.4 promoters, and hypoacetylation at H3K9 in PII and hypermethylation at H3K9 in PI.4 were observed in CYP19A1 gene in endometriosis patients (P < 0.05). Moreover, a decreased level of ERβ binding to PII and an increased level of its binding to PI.3 and PI.4 promoters of CYP19A1 were observed in endometriosis patients when compared to control. Conclusion Significant reduction of CYP19A1 gene expression in CCs of endometriosis patients may be the result of epigenetic alterations in its regulatory regions, either by DNA methylation or histone modifications. These epigenetic changes along with differential binding of ERβ (as a transcription factor) in CYP19A1 promoters may impair follicular steroidogenesis, leading to poor Oocyte and embryo condition in endometriosis patients.

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Pathogenic mechanisms in endometriosis-associated infertility

Cited by 362 publications

References 99 publications

Tubal transport of gametes and embryos: a review of physiology and pathophysiology

Tubal transport of gametes and embryos: a review of physiology and pathophysiology

Treatment of Endometriosis in Women Desiring Fertility

Epigenetic alterations of CYP19A1 gene in Cumulus cells and its relevance to infertility in endometriosis

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