Pathogenic mechanisms of glucocorticoid-induced osteoporosis

Chen, Meng; Fu, Weijie; Xu, Huiyun; Liu, Chuanju

doi:10.1016/j.cytogfr.2023.03.002

Cited by 43 publications

(21 citation statements)

References 170 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 40 Specifically, GCs inhibit the proliferation and differentiation of osteoblasts, elevate the apoptosis of osteoblasts and osteocytes, and increase osteoclastogenesis. 281 , 282 GCs induce autophagy in osteoblasts and inhibit their proliferation by downregulating the Wnt and MAPK signaling pathways. 258 For osteocytes, GCs induce their apoptosis by increasing the influx of Ca 2+ and promoting the Pyk2-JNK signaling pathway.…”

Section: Molecular Mechanisms Underlying Sexual Dimorphism In Osteopo...mentioning

confidence: 99%

Insights and implications of sexual dimorphism in osteoporosis

Zhang,

Xie,

Sun

et al. 2024

Bone Res

View full text Add to dashboard Cite

Osteoporosis, a metabolic bone disease characterized by low bone mineral density and deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures worldwide. Accumulating evidence has revealed that sexual dimorphism is a notable feature of osteoporosis, with sex-specific differences in epidemiology and pathogenesis. Specifically, females are more susceptible than males to osteoporosis, while males are more prone to disability or death from the disease. To date, sex chromosome abnormalities and steroid hormones have been proven to contribute greatly to sexual dimorphism in osteoporosis by regulating the functions of bone cells. Understanding the sex-specific differences in osteoporosis and its related complications is essential for improving treatment strategies tailored to women and men. This literature review focuses on the mechanisms underlying sexual dimorphism in osteoporosis, mainly in a population of aging patients, chronic glucocorticoid administration, and diabetes. Moreover, we highlight the implications of sexual dimorphism for developing therapeutics and preventive strategies and screening approaches tailored to women and men. Additionally, the challenges in translating bench research to bedside treatments and future directions to overcome these obstacles will be discussed.

show abstract

Section: Molecular Mechanisms Underlying Sexual Dimorphism In Osteopo...mentioning

confidence: 99%

Insights and implications of sexual dimorphism in osteoporosis

Zhang,

Xie,

Sun

et al. 2024

Bone Res

View full text Add to dashboard Cite

show abstract

“…[ 31 ] Glucocorticoid-induced OP represents the most common form of secondary OP. [ 32 ] On the one hand, glucocorticoids directly inhibit osteoblast proliferation and differentiation, as well as suppress the production of osteoblast-specific markers (osteocalcin, bone-specific alkaline phosphatase) through the insulin-like growth factor I (IGF-I) and Wnt signaling pathways. [ 32 , 33 ] On the other hand, glucocorticoids activate Caspase3 through various apoptotic signaling pathways, promoting apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Causal relationship between chronic obstructive pulmonary disease and BMD at different sites: A bidirectional Mendelian randomization study

Jiang,

Mou,

Luo

et al. 2023

Medicine

View full text Add to dashboard Cite

Observational studies have demonstrated a correlation between chronic obstructive pulmonary disease (COPD) and osteoporosis (OP). However, it is unclear whether there is genetic causality between COPD and bone mineral density (BMD) reduction at different sites. This study assessed the causal relationship between COPD and BMD in various anatomical locations. Data associated with COPD and BMD were obtained from published genome-wide association studies (GWAS). We selected single nucleotide polymorphisms (SNPs) that were strongly associated with COPD and BMD could serve as instrumental variables for the analysis. Inverse variance weighted, MR-Egger and weighted median were manipulated to evaluate causality. Subsequently, we conducted heterogeneity tests using Cochran Q test and tested for pleiotropy using the MR-Egger intercept. We performed leave-one-out sensitivity analysis to assess the robustness of the results. Additionally, we obtained more accurate causal genetic associations by removing any pleiotropic outlying SNPs and performed Mendelian randomization (MR) analysis with the remaining data. Our findings established that COPD was negatively associated with Heel-BMD (odds ratio[OR] = 0.978, 95% confidence interval [CI] = 0.966, 0.990, P = .0003) but not LS-BMD (OR = 0.981, 95% CI: 0.943, 1.020, P = .335), FA-BMD (OR = 0.984, 95% CI: 0.927, 1.046, P = .616), and FN-BMD (OR = 0.981, 95% CI: 0.950, 1.014, P = .249). In reverse MR analysis, the results showed no significant causal effect of BMD at different sites on COPD. The results were proved to be dependable and steady by sensitivity, heterogeneity, and pleiotropy analysis. We found that COPD increases the risk of decreased heel BMD, however, there is no evidence that the loss of BMD increases the risk of COPD.

show abstract

“…The most prevalent kind of secondary osteoporosis is caused by GCs. 56 Recently identified as a form of controlled cell death, ferroptosis is closely associated with lipid peroxidation and bone development in GC-induced osteoporosis. 57 In MC3T3-E1 cells and mice, endothelial cell-secreted exosomes (EC-Exos) have the potential to cure GCs-induced osteoporosis by preventing apoptosis and ferritinophagy-dependent ferroptosis.…”

Section: The Potential Therapeutic Effects Of Evs In Osteogenic Diffe...mentioning

confidence: 99%

The Potential of Exosomes for Osteoporosis Treatment: A Review

He,

Chen

2024

DDDT

View full text Add to dashboard Cite

As a continuous process comprising bone resorption and formation, bone remodeling, plays an essential role in maintaining the balance of bone metabolism. One type of metabolic osteopathy is osteoporosis, which is defined by low bone mass and deteriorating bone microstructure. Osteoporosis patients are more likely to experience frequent osteoporotic fractures, which makes osteoporosis prevention and treatment crucial. A growing body of research has revealed that exosomes, which are homogenous vesicles released by most cell types, play a major role in mediating a number of pathophysiological processes, including osteoporosis. Exosomes may act as a mediator in cell-to-cell communication and offer a fresh perspective on information sharing. This review discusses the characteristics of exosomes and outlines the exosomes’ underlying mechanism that contributes to the onset of osteoporosis. Recent years have seen a rise in interest in the role of exosomes in osteoporosis, which has given rise to innovative therapeutic approaches for the disease prevention and management.

show abstract

Pathogenic mechanisms of glucocorticoid-induced osteoporosis

Cited by 43 publications

References 170 publications

Insights and implications of sexual dimorphism in osteoporosis

Insights and implications of sexual dimorphism in osteoporosis

Causal relationship between chronic obstructive pulmonary disease and BMD at different sites: A bidirectional Mendelian randomization study

The Potential of Exosomes for Osteoporosis Treatment: A Review

Contact Info

Product

Resources

About