Pathogenic mechanisms of postinfectious functional gastrointestinal disorders: Results 3 years after gastroenteritis

Abstract

Three years after salmonellosis, PI-FGID patients showed no evidence of inflammation in the gastric or colonic mucosa, but visceral sensitivity and anxiety/somatization levels were increased. The close anatomical mast cell-nerve fibers relation does not seem to be related to the FGID but to the infection itself.

Pathophysiology of Functional Gastrointestinal Disorders: A Holistic Overview

“…This hypothesis is supported by studies that have demonstrated a higher prevalence of symptoms compatible with IBS in individuals with a prior history of acute enteric infection, compared with those without such exposure [42, 60, 61]. The fact that population-based studies demonstrate a link between mucosal eosinophilia in FGID patients and co-existing colonic spirochetosis [44] is also consistent with the concept of an infectious agent [62, 63]. Besides the histological evidence of mucosal inflammation, some investigators have shown activation of the immune system in patients with IBS, reflected by increased levels of cytokines in the colonic mucosa [64], as well as an increase in release of proinflammatory cytokines from isolated PBMCs, particularly in patients with IBS-D [16], and also in patients with FD [65].…”

Mucosal inflammation as a potential etiological factor in irritable bowel syndrome: a systematic review

“…This concept was first proposed almost 20 years ago [15], and in latter years has been supported by numerous studies that demonstrate a higher prevalence of symptoms compatible with IBS in individuals with prior exposure to acute enteric infection, compared with those without such exposure [16][17][18][19][20]. A few studies have demonstrated increased levels of pro-inflammatory cytokines and higher numbers of mast cells [20][21][22], the latter in close proximity to enteric nerve fibers in the GI mucosa of these individuals.…”

Síndrome del intestino irritable y enfermedad inflamatoria intestinal: ¿alguna conexión?

“…Esta circunstancia se ha observado en un estudio prospectivo realizado por este grupo, en el que a los 3 años de un brote de gastroenteritis aguda por Salmonella la mucosa de pacientes en los que se había desarrollado SII o DF mostraba un número similar de células inmunes y una producción de citocinas equiparable a los controles 47 (fig. 4).…”