2024
DOI: 10.1186/s12935-024-03536-6
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Pathogenic nsSNPs of protein kinase C-eta with hepatocellular carcinoma susceptibility

Tayyaba Hussain,
Yasmin Badshah,
Maria Shabbir
et al.

Abstract: Background Hepatocellular carcinoma (HCC) is a global health concern. Due to late diagnosis and limited therapeutic strategies, HCC based mortality rate is exponentially increasing globally. Genetic predisposition is a non-avoidable intrinsic factor that could alter the genome sequence, ultimately leading to HCC. Protein kinase C eta (PKCη) is involved in key physiological roles, hence alteration in PKCη could aid in cancer progression. Research indicates association between non-synonymous (ns) SN… Show more

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