Pathogenic role of microRNAs in atherosclerotic ischemic stroke: Implications for diagnosis and therapy

Chitosan Nanoparticles in Atherosclerosis—Development to Preclinical Testing

“…More mature lesions have pools of extracellular lipid and foam cells that have collected at the site ( Figure 1 ) from macrophages and VSMCs in the artery wall [ 36 ]. These lesions are contained by a fibrous capsule made up of VSMCs that have migrated to underline the above VECs [ 37 ]. Stable plaques are characterised by a relatively small lipid core enclosed by a thick fibrous cap, whereas unstable plaques are mostly characterised by a large lipid core covered by a thin fibrous cap and are prone to rupturing at any time [ 36 ].…”

Profiling of differentially expressed MicroRNAs in familial hypercholesterolemia via direct hybridization

“…The PI3K-Akt as well as TGF-β signaling pathways in hyperlipidemia. Likewise, PI3K signaling pathway could be targeted by a some miRNAs, such as miR-147 and miR-223 [ 44 ]. This latter is transported also by high-density lipoprotein (HDL) in patients with HoFH [ 45 ].…”

Effects of Controlled Ozone Exposure on Circulating microRNAs and Vascular and Coagulation Biomarkers: A Mediation Analysis

“…miR-122-5p is a key regulator of the SIRT6-elabela-ACE2 signaling pathway that is involved in angiotensin II-mediated apoptosis and oxidative stress in vascular endothelial cells [ 34 ]. Circulating miR-150-5p , miR-342-3p , and miR-34a-5p are also being investigated as biomarkers of acute heart failure [ 35 ] and vascular inflammation associated with vascular diseases [ 36 , 37 , 38 ]. Therefore, these altered expression levels of miRNAs may implicate multiple molecular mechanisms involved in cardiovascular disease induced by O 3 exposure.…”