Pathogenic role of mitogen activated protein kinases in protozoan parasites

Kaur, Prabhleen; Goyal, Neena

doi:10.1016/j.biochi.2021.10.012

Cited by 3 publications

(1 citation statement)

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“…Some clinical findings indicate that p53 exerts a potent role in functional recovery in TBI, thus suggesting that a p53 treatment strategy can be used in TBI (Mellett et al, 2020 ). MAPKs, including MAPK1, is a well‐reported kinase for diversified biological functions, such as inflammation, apoptosis, cancerization (Kaur & Goyal, 2021 ). Targeting the suppression of MAPK1 may be a potential treatment for TBI‐induced neuronal damage (Bhowmick et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Preclinical findings reveal the pharmacological targets of ferulic acid in the treatment of traumatic brain injury

Dong¹,

Yang²,

Liao³

et al. 2022

Food Science & Nutrition

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Traumatic brain injury (TBI) is characterized by cellular damage and inflammation in lesioned brain tissue. Ferulic acid has been shown to have a melioration effect on neurological functions. However, the active pharmacological effects and the underlying mechanisms of ferulic acid against TBI remain unclear. On the basis of network pharmacology and molecular docking methodology, this study aimed to investigate the beneficial effects of ferulic acid in treating TBI, and characterized the detailed biotargets and mechanisms of these actions. The identified core targets were validated via in silico simulation. We identified 91 overlapping targets associated with ferulic acid and TBI. In‐silico simulation analysis validated the putative core targets of tumor protein p53, mitogen‐activated protein kinase (MAPK) 1, and estrogen receptor 1. The Gene Ontology‐enriched annotations and findings were largely associated with cell proliferation, apoptosis, and inflammation in nerve cells. Additional Kyoto Encyclopedia of Genes and Genomes enrichment analysis unmasked the pharmacological pathways of ferulic acid in treating TBI, including the MAPK signaling pathway and hypoxia‐inducible factor‐1 signaling pathway. Bioinformatic analyses and findings provide a new preclinical strategy for revealing the core targets and network pathways of ferulic acid in treating TBI. Moreover, some bioinformatic findings were computationally validated in silico for exhibiting the neuroprotective action of ferulic acid against TBI.

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Section: Discussionmentioning

confidence: 99%