Pathogenic role of tissue-resident memory T cells in autoimmune diseases

Wu, Haijing; Liao, Wei; Li, Qianwen; Long, Hai; Yin, Heng; Zhao, Ming; Chan, Vera Sau-Fong; Lau, Chak Sing; Lu, Qianjin

doi:10.1016/j.autrev.2018.03.014

Cited by 79 publications

(60 citation statements)

References 60 publications

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“…T RM cells have been described in both mouse and human tissues such as lung, intestine, brain and skin 1,2,3,4 and show a transcriptional profile that is, among others, characterized by CD69 expression and in some tissues also CD103 expression 5,6,7 . The T RM cells that reside at peripheral sites orchestrate immune responses against pathogens, but also contribute to autoimmune and allergic disorders 4,8,9,10 . Furthermore, CD103 + T cells are present in human cancer lesions such as melanoma 11 , ovarian 12 and lung cancer 13,14 , are enriched in tumor reactivity 15 and are therefore thought to play a central role in tumor control.…”

Section: Introductionmentioning

confidence: 99%

Tissue patrol by resident memory CD8+ T cells in human skin

et al. 2019

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Emerging data show that tissue-resident memory T cells (T RM) play an important protective role at murine and human barrier sites. Mouse skin-T RM cells in the epidermis patrol their surroundings and rapidly respond upon antigen encounter. However, whether a similar migratory behavior is performed by human T RM cells is unclear, as technology to longitudinally follow them in situ has been lacking. To address this issue, we developed an ex vivo culture system to label and track T cells in fresh skin samples. We validated this system by comparing in vivo and ex vivo properties of murine T RM cells. Using nanobody labeling, we subsequently demonstrate in human ex vivo skin that CD8 + T RM cells migrated through the papillary dermis and the epidermis, below sessile Langerhans cells. Collectively, this work allows the dynamic study of resident immune cells in human skin and demonstrates the existence of tissue patrol by human CD8 + T RM cells. Dijkgraaf, et al.

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Section: Introductionmentioning

confidence: 99%

Tissue patrol by resident memory CD8+ T cells in human skin

et al. 2019

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“…They recirculate among blood, T cell zones of secondary lymphoid organs, lymph and non-lymphoid tissues, such as the skin, where they act as alarm sensors or cytotoxic killers. They are characterized by heterogeneity depending on their origin [5,[7][8][9][10][11].…”

Section: Tissue Resident Memory Cells (Trm)mentioning

confidence: 99%

“…Since, HSV-specific TRMs have been found in the skin, rotavirus-specific TRMs in the intestines and flu-specific TRMs in the lungs [16,17]. However, in addition to their protective functions, there is more and more evidence of their involvement in the pathogenesis of autoimmune disorders such as psoriasis, vitiligo, autoimmune hepatitis, rheumatoid arthritis and lymphomas [11].…”

Section: Tissue Resident Memory Cells (Trm)mentioning

confidence: 99%

“…Even after the clinical lesions have resolved, they are capable of producing IL-17A, and effective therapy only suppresses their activity [3,37]. Furthermore, CD8+ TRM cells accumulate in untreated psoriasis localizations, probably in correlation with disease duration [4,11]. An interesting issue is the explanation of the longevity of memory cells.…”

Section: Tissue Resident Memory Cells In Psoriasismentioning

confidence: 99%

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Immunological Memory of Psoriatic Lesions

Owczarczyk‐Saczonek

Krajewska–Włodarczyk

Kasprowicz-Furmańczyk

et al. 2020

IJMS

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The natural course of psoriasis is the appearance of new lesions in the place of previous ones, which disappeared after a successful therapy. Recent studies of psoriasis etiopathogenesis showed that after psoriatic plaques have disappeared, in healthy skin we can still find a trace of inflammation in the form of tissue resident memory cells (TRM). They are originally responsible for protection against viral and bacterial infections in non-lymphatic tissues. In psoriatic inflammation, they are characterized by heterogeneity depending on their origin. CD8+ T cells TRM are abundantly present in psoriatic epidermis, while CD4+ TRM preferentially populate the dermis. In psoriasis, epidermal CD8+ TRM cells express CLA, CCR6, CD103 and IL-23R antigen and produce IL-17A during ex vivo stimulation. However, CD4+ CD103+ TRM can also colonize the epidermis and produce IL-22 during stimulation. Besides T cells, Th22 and epidermal DCs proved that epidermal cells in healed skin were still present and functioning after several years of disease remission. It explains the clinical phenomenon of the tendency of psoriatic lesions to relapse in the same location and it allows to develop new therapeutic strategies in the future.

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“…Characteristically, TRM cells express CD103 and CD69. CD49a, which binds to the extracellular collagen and laminin, can be added to these two for the skin tissue [21,23,93]. TRM cells do not express or express very low levels of lymph node homing molecules which are required for tissue exit such as CD62L, CCR7, and S1PR1 and it is critical for TRM cell tissue residency [1,15,53,67,69].…”

Section: Phenotypementioning

confidence: 99%

Resident Memory T Cells

Akbaba¹

2020

Cells of the Immune System

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Until recently, T cells were thought to remain in circulation until recruitment of the inflammation and only a small number of T cells remained in the peripheral tissues without inflammation. However, studies have found that a group of T cells settled in the tissues and remained there for a long time. Those cells are named as tissue-resident memory T cells (TRM). TRM cells are transcriptionally, phenotypically, and functionally distinct from other T cells, which recirculate between blood, secondary lymphoid organs, and non-lymphoid tissues. They undergo a distinct proliferation that discriminates them from circulating T cells and their main cell surface markers are CD69, CD103, and CD49a. Upon exposure to the same or similar diseases, TRM cells provide a first line of adaptive cellular defense against infection in peripheral non-lymphoid tissues, such as skin, lungs, digestive, and urogenital tracts. This approach forms the basis of a novel vaccination strategy called "prime and pull", which ensures long-term local immunity. On the other hand, abnormal activated and malignant TRM may contribute to numerous human inflammatory diseases such as psoriasis and vitiligo. Here in this chapter, we aimed to emphasize TRM cell location, migration, phenotypic structure, maintenance, and diseases associated with TRM cells.

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Pathogenic role of tissue-resident memory T cells in autoimmune diseases

Cited by 79 publications

References 60 publications

Tissue patrol by resident memory CD8+ T cells in human skin

Tissue patrol by resident memory CD8+ T cells in human skin

Immunological Memory of Psoriatic Lesions

Resident Memory T Cells

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