Pathogenic Significance of Coagulase-Negative Staphylococci

Pulverer, G.; Pillich, J

doi:10.1007/978-3-642-65267-7_10

Cited by 23 publications

(14 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Until relatively recently, they were regarded as contaminants of clinical samples rather than as potential pathogens. However, they have emerged as a significant problem in medical-device-related infections associated with indwelling catheters, prosthetic heart valves and cerebrospinal fluid shunts (Gemmel, 1986;Pulverer et al, 1987;Gemmel & McCartney, 1990;Peters et al, 1990). In patients undergoing treatment for renal failure by continuous ambulatory peritoneal dialysis (CAPD), the CNS, and in particular S .…”

Section: Introductionmentioning

confidence: 99%

“…The virulence determinants of the CNS have not been well characterized, although the pathogenesis of CNS infections has been related to bacterial adherence to host tissues and polymer implant surfaces (Christensen, 1987 ;Pulverer et al, 1987;Peters et al, 1990). The molecular basis of these interactions has not yet been fully established, but scanning electron microscopy has revealed that following the initial adherence events, the CNS form biofilms on the surface of implants (Bayston & Penny, 1972;Peters et al, 1981 ;Marrie et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Variation in the expression of cell envelope proteins of coagulase-negative staphylococci cultured under iron-restricted conditions in human peritoneal dialysate

Wilcox

Williams

Smith

et al. 1991

Journal of General Microbiology

View full text Add to dashboard Cite

Strains of coagulase-negative staphylococci (CNS), including Staphylococcus epidermids, S. hominis, S. warnerii, S. simulans, S. capitis, S. haemolyticus and S. saprophyticus, were isolated from patients with continuousambulatory-peritoneal-dialysis-related peritonitis. The cell wall and cytoplasmic membrane protein profiles of CNS strains cultured in either nutrient broth (NB) or pooled human peritoneal dialysate (HPD) were compared. Some interspecies variation in both the wall and membrane protein profiles was noted. However, the cell wall protein profiles of HPD-grown CNS strains differed markedly from those cultured in NB. Growth in HPD resulted in a marked reduction in the total number of cell-wall-associated proteins but up to three antigenically related proteins in the 40-56 kDa range, depending on the species, predominated. Growth in HPD also resulted in the induction of two iron-repressible cytoplasmic membrane proteins (IRMPs) of 32 and 36 kDa in S. epidermidis. Other CNS strains only appeared to express a single IRMP, which varied in molecular mass from 32 to 36 kDa. Whilst the IRMP in these CNS strains showed considerable antigenic homology with the 32 kDa IRMP, the S. warneri IRMP showed cross-reactivity with both the 32 and 36 kDa IRMPs of S. epidermidis. Immunoblotting experiments revealed that whilst the CNS cell wall proteins were poorly immunogenic, the IRMPs were the immunodominant CNS protein antigens, reacting strongly with antibodies present in HPD. This finding provides evidence to suggest that the IRMPs are expressed in vivo during infection.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Variation in the expression of cell envelope proteins of coagulase-negative staphylococci cultured under iron-restricted conditions in human peritoneal dialysate

Wilcox

Williams

Smith

et al. 1991

Journal of General Microbiology

View full text Add to dashboard Cite

show abstract

“…under certain conditions may cause several human diseases. Coagulase-negative staphylococcal (CNS) strains often play a role in nosocomial infections, in particular in those related to foreign body implantation or administration of immunosuppressive drugs (9,10,16,(28)(29)(30)32).…”

mentioning

confidence: 99%

Phage Pattern and Antibiotic Resistance Pattern of Coagulase‐Negative Staphylococci Obtained from Immunocompromised Patients

Barcs¹,

Herendi²,

Lipcsey³

et al. 1992

Microbiology and Immunology

View full text Add to dashboard Cite

show abstract

“…Staphylococcus epidermidis is a major microbial inhabitant of the skin and mucosal surfaces of the human body (Pulverer et al, 1987). Currently, S. epidermidis has become the most prevalent species of coagulase-negative Staphylococci (CoNS) leading to nosocomial bloodstream infections (Banerjee et al, 1991;Jones, 1996).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activities of YycG histidine kinase inhibitors againstStaphylococcus epidermidisbiofilms

Qin

Lee

Yang

et al. 2007

FEMS Microbiology Letters

View full text Add to dashboard Cite

Staphylococcus epidermidis has become a significant pathogen causing infections due to biofilm formation on surfaces of indwelling medical devices. Biofilm-associated bacteria exhibit enhanced resistance to many conventional antibiotics. It is therefore, important to design novel antimicrobial reagents targeting S. epidermidis biofilms. In a static chamber system, the bactericidal effect of two leading compounds active as YycG inhibitors was assessed on biofilm cells by confocal laser scanning microscopy combined with viability staining. In young biofilms (6-h-old), the two compounds killed the majority of the embedded cells at concentrations of 100 microM and 25 microM, respectively. In mature biofilms (24-h-old), one compound was still effectively killing biofilm cells, whereas the other compound mainly killed cells located at the bottom of the biofilm. In contrast, vancomycin was found to stimulate biofilm development at the MBC (8 microg mL(-1)). Even at a high concentration (128 microg mL(-1)), vancomycin exhibited poor killing on cells embedded in biofilms. The two compounds exhibited faster and more effective killing of S. epidermidis planktonic cells than vancomycin at the early stage of exposure (6 h). The data suggest that the new inhibitors can serve as potential agents against S. epidermidis biofilms when added alone or in concert with other antimicrobial agents.

show abstract

Pathogenic Significance of Coagulase-Negative Staphylococci

Cited by 23 publications

References 13 publications

Variation in the expression of cell envelope proteins of coagulase-negative staphylococci cultured under iron-restricted conditions in human peritoneal dialysate

Variation in the expression of cell envelope proteins of coagulase-negative staphylococci cultured under iron-restricted conditions in human peritoneal dialysate

Phage Pattern and Antibiotic Resistance Pattern of Coagulase‐Negative Staphylococci Obtained from Immunocompromised Patients

Antimicrobial activities of YycG histidine kinase inhibitors againstStaphylococcus epidermidisbiofilms

Contact Info

Product

Resources

About