Pathogenic Variants of Scavenger Receptor
            <i>CD36</i>
            Lead to Decreased Efferocytosis and Predispose to Myocarditis Following Vaccination With Pfizer-BioNTech BNT162b2 Against Coronavirus Infection (COVID-19)

Canavati, Christina; Siam, Ahmad; Labes, Sapir; Trabelsi, Nirit; Regev, Eshcar; Parnasa, Elchanan; Barhoum, Barhoum; Magadle, Nur; Perzon, Ofer; Braun, Maya; Mor-Shaked, Hagar; Schueler-Furman, Ora; Tabach, Yuval; Mevorach, Dror

doi:10.1161/circulationaha.123.064884

Cited by 2 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With increased CD36 expression, the ability of DCs to engulf apoptotic cells significantly enhances. This finding not only provides new insights into the function of CD36 in the efferocytosis process of DCs but also corroborates its known role in promoting the clearance of apoptotic cells in macrophages ( 135 ), indicating that CD36 has a consistent functional across different types of phagocytes.…”

Section: Unveiling the Receptors: Recognition Of Apoptotic Cells By D...supporting

confidence: 76%

“…Comparative studies of efferocytosis rates between wild-type and CD36-deficient mice DCs show negligible differences (134), suggesting that CD36 may not be critical for DC efferocytosis. This observation contrasts with the role of CD36 in macrophages (135). However, subsequent research has found that CD36 plays a significant role in the efficiency of efferocytosis in DCs (101).…”

Section: Integrin Scavenger and Cd300 Receptors In DC Efferocytosismentioning

confidence: 86%

See 1 more Smart Citation

Efferocytosis in dendritic cells: an overlooked immunoregulatory process

Ma,

Jiang,

Zhu

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Efferocytosis, the process of engulfing and removing apoptotic cells, plays an essential role in preserving tissue health and averting undue inflammation. While macrophages are primarily known for this task, dendritic cells (DCs) also play a significant role. This review delves into the unique contributions of various DC subsets to efferocytosis, highlighting the distinctions in how DCs and macrophages recognize and handle apoptotic cells. It further explores how efferocytosis influences DC maturation, thereby affecting immune tolerance. This underscores the pivotal role of DCs in orchestrating immune responses and sustaining immune equilibrium, providing new insights into their function in immune regulation.

show abstract

Section: Unveiling the Receptors: Recognition Of Apoptotic Cells By D...supporting

confidence: 76%

Section: Integrin Scavenger and Cd300 Receptors In DC Efferocytosismentioning

confidence: 86%

Efferocytosis in dendritic cells: an overlooked immunoregulatory process

Ma,

Jiang,

Zhu

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

Hidden features: CD36/SR-B2, a master regulator of macrophage phenotype/function through metabolism

Chen,

Zhang,

Huang

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Once thought to be in a terminally differentiated state, macrophages are now understood to be highly pliable, attuned and receptive to environmental cues that control and align responses. In development of purpose, the centrality of metabolic pathways has emerged. Thus, macrophage inflammatory or reparative phenotypes are tightly linked to catabolic and anabolic metabolism, with further fine tuning of specific gene expression patterns in specific settings. Single-cell transcriptome analyses have revealed a breadth of macrophage signatures, with some new influencers driving phenotype. CD36/Scavenger Receptor B2 has established roles in immunity and lipid metabolism. Macrophage CD36 is a key functional player in metabolic expression profiles that determine phenotype. Emerging data show that alterations in the microenvironment can recast metabolic pathways and modulate macrophage function, with the potential to be leveraged for therapeutic means. This review covers recent data on phenotypic characterization of homeostatic, atherosclerotic, lipid-, tumor- and metastatic-associated macrophages, with the integral role of CD36 highlighted.

show abstract

Pathogenic Variants of Scavenger Receptor CD36 Lead to Decreased Efferocytosis and Predispose to Myocarditis Following Vaccination With Pfizer-BioNTech BNT162b2 Against Coronavirus Infection (COVID-19)

Cited by 2 publications

References 5 publications

Efferocytosis in dendritic cells: an overlooked immunoregulatory process

Efferocytosis in dendritic cells: an overlooked immunoregulatory process

Hidden features: CD36/SR-B2, a master regulator of macrophage phenotype/function through metabolism

Contact Info

Product

Resources

About