Pathogenicity of &lt;i&gt;Trypanosoma brucei&lt;/i&gt; in African giant rats (&lt;i&gt;Cricetomys gambianus&lt;/i&gt;, Water House)

Audu, PA; Moveh, EB

doi:10.4314/nvj.v25i1.3465

Cited by 2 publications

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“…However, lesion in brain seems to be irreversible and may be one of the causes of death of the bandicoot suffering from T. (T.) evansi along with the irreversible changes developed in several visceral organs (Biswas et al, 2001). Later, Audu et al (2008) reported histopathology of visceral organs of T. brucei-infected African Giant Rat, Cricetomys gambianus, which confirms the observations made by Biswas et al (2001) in T. evansi-infected bandicoot rat.…”

Section: Discussionsupporting

confidence: 64%

Histopathology of Trypanosoma (Trypanozoon) evansi infection in Bandicoot rat. II. Brain and choroid plexus

2010

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Bandicoot rat, Bandicota bengalensis, received intraperitoneal inoculation of Trypanosoma (Trypanozoon) evansi flagellates and showed acute disease, leading to death during the 2 nd peak of parasitaemia [14 th day post infection (pi)]. Damage in brain and choroid plexus of the infected bandicoot is studied on the 5 th , 8 th , 12 th and 14 th day post inoculation. Sign of histopathological changes in the brain and choroid plexus of the bandicoot are detected after 1 st peak of parasitaemia. Infiltration of lymphocyte and plasma cells, congestion, perivascular cuffing, gliosis and brain lesions are observed during 12 th -14 th day post intection. Multiple sclerosis, neuronophagia, focal haemorrhage, cerebral hyperplasia, oligodendrocytoma, astrocytoma and fatty degeneration of brain tissue are also found. Alteration in the ependymal cells of choroid plexus is noticed. Extensive oedema, infiltration of inflammatory cells and rupture of ventricular ependymal layer are found. Parasites are found both in the brain tissue and choroid plexus. No intracellular stage of the parasite is observed. The nature of damage in the brain tissue and choroid plexus shows similarity with the cases of African trypanosomiasis. This salivarian species cause more deleterious effect in brain much earlier in the disease course than its African relatives.

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Section: Discussionsupporting

confidence: 64%

Histopathology of Trypanosoma (Trypanozoon) evansi infection in Bandicoot rat. II. Brain and choroid plexus

2010

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“…Cricetomys gambianus in addition controls insects by keeping their population low, and also play major role in seed dispersal (Joo and Myers, 2004;Cooper, 2008). They are useful animal model in biomedical research and provide vital information on mammal physiology and behaviour (Audu et al, 2008). The giant rat has been found living in close association with man, searching for food such as nuts and other household items and leftover food.…”

Section: Introductionmentioning

confidence: 99%

INTESTINAL PARASITIC FAUNA AND PREVALENCE IN AFRICAN GIANT RAT (Cricetomys gambianus) IN NSUKKA METROPOLIS SOUTH EASTERN NIGERIA

Onah

Umeike²

2022

FJS

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to combat food insecurity and malnutrition among the local populace. However, the giant rat has been reported to harbour many parasites thus, its close association with man in raising them as mini-livestock and the consumption of the meat could be a public health risk to individuals handling them. This study was conducted to investigate the gut parasites and their prevalence on African giant rat in Nsukka metropolis. A total of 21 giant rats comprising 13 males and 8 females were trapped for the study. The giant rats were dissected, and the guts were removed and searched for parasites. A total of 506 parasites where recovered. Four different parasites Trichostrongylus sp., Trichuris muris (nematodes) and Hymenolepis diminuta and Taenia sp. (Platyhelminthes) were identified in the gastrointestinal tract of the giant rats. Hymenolepis diminuta was the most prevalent (100%) while Taenia sp. had the highest mean intensity of 10.15 (7.46 – 12.85, 95% CI) followed by Trichostrongylus sp. Taenia sp. is significantly higher in the caecum of males than the females (p< 0.05). The weight of African giant rat has positive correlation with the prevalence and intensity of the parasites. Given the parasitic load of African giant rats it is recommended that the giant rat should be reared to reduce the intensity of parasitic infection and increase the market value since the farmed ones will be regularly dewormed.

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Pathogenicity of <i>Trypanosoma brucei</i> in African giant rats (<i>Cricetomys gambianus</i>, Water House)

Cited by 2 publications

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Histopathology of Trypanosoma (Trypanozoon) evansi infection in Bandicoot rat. II. Brain and choroid plexus

Histopathology of Trypanosoma (Trypanozoon) evansi infection in Bandicoot rat. II. Brain and choroid plexus

INTESTINAL PARASITIC FAUNA AND PREVALENCE IN AFRICAN GIANT RAT (Cricetomys gambianus) IN NSUKKA METROPOLIS SOUTH EASTERN NIGERIA

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