Pathogenicity of Sars-Cov-2 Spike Protein Variants Correlates with Coagulation and Complement Assays

Gerber, Gloria; Pan, Xiang-Zuo; Ranjan, Nikhil; Warmack, Anna

doi:10.1182/blood-2022-169738

Cited by 2 publications

(2 citation statements)

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“…There are limited studies about this field of study. The in‐vitro study indicates more potential for coagulation in the alpha variant in compare with the Omicron 109 . In addition, in clinically evaluated samples, Omicron variants are less competent for micro clot formation or coagulation abnormalities in comparison with alpha, beta and delta variants 110,111 .…”

Section: Covid‐19 Coagulopathy and Induced Thromboembolic Eventsmentioning

confidence: 88%

“…The in‐vitro study indicates more potential for coagulation in the alpha variant in compare with the Omicron. 109 In addition, in clinically evaluated samples, Omicron variants are less competent for micro clot formation or coagulation abnormalities in comparison with alpha, beta and delta variants. 110 , 111 As a point of view, it seems that one of the aspects of less sever Omicron variant infection in compare with previous variants is associated with its coagulation alteration profile.…”

Section: Covid‐19 Coagulopathy and Induced Thromboembolic Eventsmentioning

confidence: 99%

See 1 more Smart Citation

Coagulopathy and thromboembolic events a pathogenic mechanism of COVID‐19 associated with mortality: An updated review

Yousefi

Soltani

Siri

et al. 2023

Clinical Laboratory Analysis

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During 2019, the SARS‐CoV‐2 emerged from China, and during months, COVID‐19 spread in many countries around the world. The expanding data about pathogenesis of this virus could elucidate the exact mechanism by which COVID‐19 caused death in humans. One of the pathogenic mechanisms of this disease is coagulation. Coagulation disorders that affect both venous and arterial systems occur in patients with COVID‐19. The possible mechanism involved in the coagulation could be excessive inflammation induced by SARS‐CoV‐2. However, it is not yet clear well how SARS‐CoV‐2 promotes coagulopathy. However, some factors, such as pulmonary endothelial cell damage and some anticoagulant system disorders, are assumed to have an important role. In this study, we assessed conducted studies about COVID‐19‐induced coagulopathy to obtain clearer vision of the wide range of manifestations and possible pathogenesis mechanisms.

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Section: Covid‐19 Coagulopathy and Induced Thromboembolic Eventsmentioning

confidence: 88%

Section: Covid‐19 Coagulopathy and Induced Thromboembolic Eventsmentioning

confidence: 99%

Coagulopathy and thromboembolic events a pathogenic mechanism of COVID‐19 associated with mortality: An updated review

Yousefi

Soltani

Siri

et al. 2023

Clinical Laboratory Analysis

View full text Add to dashboard Cite

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The Interaction of Complement and Intrinsic Coagulation System: A Comparative Study between COVID-19 and Bacterial Sepsis Patients

Papadakis,

Politou,

Pittaras

et al. 2024

JCM

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Background/Objectives: Through the past several years, a constant interaction has been implicated between complement and coagulation cascades. SARS-CoV-2 infection and bacterial sepsis are potent activators of both cascades. This study aims to compare the extent of complement and intrinsic coagulation pathway activation (and the interplay between them) among patients with COVID-19 and bacterial sepsis. Methods: Serum and plasma samples were collected from 25 ICU patients (11 patients with COVID-19 and 14 patients with bacterial sepsis) at two time points (on admission and either on improvement or deterioration). The activities of coagulation factors XI and XII and complement factors C3a and C5a were measured at both time points. Results: The activities of factors XI and XII were increased in both groups of patients and at both time points. However, there were no statistically significant differences between SARS-CoV-2 and bacterial sepsis patients. On the other hand, both C3a and C5a were significantly higher in the COVID-19 group on admission. This correlation was preserved on reassessment. Conclusions: Complement activation seems to be more enhanced in COVID-19 than bacterial sepsis. However, the lack of statistical significance in factors XI and XII indicates t the presence of additional pathways for complement activation in SARS-CoV-2 infection.

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Pathogenicity of Sars-Cov-2 Spike Protein Variants Correlates with Coagulation and Complement Assays

Cited by 2 publications

References 0 publications

Coagulopathy and thromboembolic events a pathogenic mechanism of COVID‐19 associated with mortality: An updated review

Coagulopathy and thromboembolic events a pathogenic mechanism of COVID‐19 associated with mortality: An updated review

The Interaction of Complement and Intrinsic Coagulation System: A Comparative Study between COVID-19 and Bacterial Sepsis Patients

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