Pathogenicity of Two Embryo-Passage Levels of Avian Infectious Bronchitis Virus for the Oviduct of Young Chickens of Various Ages

Crinion, R. A. P.; Hofstad, M. S.

doi:10.2307/1588818

Cited by 23 publications

(14 citation statements)

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“…Pathogenicity for the oviduct of young chickens of various ages caused by four serotypes of IBV has been reported (Crinion et al, 1971;Crinion & Hofstad, 1972a, 1972b and abnormalities in laying hens following exposure to IBV were observed. Interestingly, contrary to these findings, we did not observe gross lesions in the oviducts of chickens infected with the three QX-like viruses in the relatively short period of our experiment.…”

Section: Analysis Of Qx-like Ibvs Recently Isolated In China 51mentioning

confidence: 95%

Phylogenetic analysis of infectious bronchitis coronaviruses newly isolated in China, and pathogenicity and evaluation of protection induced by Massachusetts serotype H120 vaccine against QX-like strains

Sun

Han

et al. 2011

Avian Pathology

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Seventy-eight isolates of avian infectious bronchitis virus (IBV) were obtained from different field outbreaks in China in 2009 and genotyped with 34 reference strains. Four genotypes of IBV and three new isolates were identified by phylogenetic analysis and BLAST searches of the entire S1 gene. The results showed that most IBV strains that have circulated in China in recent years belong to the genotype of QX-like strains, and that they could be grouped further into two clusters, regardless of the level of genetic variation displayed. A study of pathogenicity that used three QX-like strains*ck/CH/LSD/091003, ck/CH/LDL/091022 and ck/CH/LJL/ 090330*showed that the isolates caused the most severe lesions in the kidneys and were therefore nephropathogenic strains with various levels of virulence in specific pathogen free chickens. A vaccinationÁ challenge test that was performed using the three QX-like strains showed that the commercially available H120 vaccine did not provide sufficient protection against challenge with the QX-like isolates, as demonstrated by comparison of the clinical signs, pathological lesions and virus recovery from the trachea and kidney of unvaccinatedÁchallenged and vaccinatedÁchallenged birds.

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Section: Analysis Of Qx-like Ibvs Recently Isolated In China 51mentioning

confidence: 95%

Phylogenetic analysis of infectious bronchitis coronaviruses newly isolated in China, and pathogenicity and evaluation of protection induced by Massachusetts serotype H120 vaccine against QX-like strains

Sun

Han

et al. 2011

Avian Pathology

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“…IBV can infect the trachea, kidney, and oviduct of the adult chicken resulting severe impairment of egg laying and poor egg quality [1,8]. Given the economic effects of IBV on the commercial poultry industry, its prevention has been continually pursued.…”

Section: Infectious Bronchitis Virus (Ibv) Belongs To the Familymentioning

confidence: 99%

Multivalent DNA Vaccine Enhanced Protection Efficacy against Infectious Bronchitis Virus in Chickens

Tai

Wang

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. For efficacious DNA vaccine development against infectious bronchitis virus (IBV), the immunogenicity of a multivalent DNA vaccine was evaluated. Three expression plasmids each targeting spike protein (S1), nucleocapsid protein (N), and membrane protein (M) of IBV were prepared. Chickens were immunized with either individual plasmids (monovalent) or with a combination of all plasmids (multivalent). Immunization with the multivalent DNA vaccine induced synergistic augmentation of humoral and cellular responses in comparison with the individual vaccines, and provided up to 85% immune protection. Thus the multivalent DNA vaccine represents an innovative approach for enhancing DNA vaccine potency, and has potential clinical application for vaccination against IBV.KEY WORDS: DNA vaccine, infectious bronchitis virus, multivalency.

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“…Infectious bronchitis virus (IBV) is a prototype of the Coronaviridae family (Collisson et al, 1992;Siddell et al, 1983). Infection with IBV causes a highly contagious, respiratory disease in chickens with high mortality in young chicks (Alexander et al, 1978;Crinion and Hofstad, 1972;Hofstad, 1984). In addition to the upper and lower respiratory tract, IBV affects the genital and urinary systems and has been isolated from many tissues, including the lung, trachea, cecal tonsils, kidneys, Harderian (paraocular) glands, and spleen (Alexander et al, 1978;Crinion and Hofstad, 1972;Hofstad, 1984).…”

Section: Introductionmentioning

confidence: 99%

Adoptive Transfer of Infectious Bronchitis Virus Primed αβ T Cells Bearing CD8 Antigen Protects Chicks from Acute Infection

et al. 2000

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Infectious bronchitis virus (IBV) infection and associated illness may be dramatically modified by passive transfer of immune T lymphocytes. Lymphocytes collected 10 days postinfection were transferred to naive chicks before challenge with virus. As determined by respiratory illness and viral load, transfer of syngeneic immune T lymphocytes protected chicks from challenge infection, whereas no protection was observed in the chicks receiving the MHC compatible lymphocytes from uninfected chicks. Protection following administration of T lymphocytes could be observed in chicks with three distinct MHC haplotypes: B(8)/B(8), B(12)/B(12), and B(19)/B(19). Nearly complete elimination of viral infection and illness was observed in chicks receiving cells enriched in alphabeta lymphocytes. In contrast, removal of gammadelta T lymphocytes had only a small effect on their potential to protect chicks. The adoptive transfer of enriched CD8(+) or CD4(+) T lymphocytes indicated that protection was also a function primarily of CD8-bearing cells. These results indicated that alphabeta T lymphocytes bearing CD8(+) antigens are critical in protecting chicks from IBV infection.

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Pathogenicity of Two Embryo-Passage Levels of Avian Infectious Bronchitis Virus for the Oviduct of Young Chickens of Various Ages

Cited by 23 publications

References 0 publications

Phylogenetic analysis of infectious bronchitis coronaviruses newly isolated in China, and pathogenicity and evaluation of protection induced by Massachusetts serotype H120 vaccine against QX-like strains

Phylogenetic analysis of infectious bronchitis coronaviruses newly isolated in China, and pathogenicity and evaluation of protection induced by Massachusetts serotype H120 vaccine against QX-like strains

Multivalent DNA Vaccine Enhanced Protection Efficacy against Infectious Bronchitis Virus in Chickens

Adoptive Transfer of Infectious Bronchitis Virus Primed αβ T Cells Bearing CD8 Antigen Protects Chicks from Acute Infection

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