Pathogens causing diarrhoea among Bangladeshi children with malignancy: Results from two pilot studies

Karim, Shanaz; Begum, Ferdousi; Islam, Asma; Tarafdar, Monowar Ahmad; Begum, Mamtaz; Islam, Johirul; Malik, Bushra; Ahsan, Shamim; Khatami, Ameneh; Rashid, Harunor

doi:10.12998/wjcc.v8.i2.276

Cited by 4 publications

(3 citation statements)

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“…However, an infection rate similar to the results of this study was reported in school children (19.3%, 54/280) from Ethiopia [32]. On the other hand, higher infections were also documented in children with malignancy (68.5%, 37/54) in Bangladesh [15].…”

Section: Discussionsupporting

confidence: 88%

“…Poor hygiene and sanitation combined with frequent exposure to animals and their excrement facilitate the zoonotic transmission of diseases. Giardia duodenalis has previously been associated with diarrhea in children from Bangladesh [13,14] and a high prevalence of giardiasis has recently been reported among humans [15]. Calves are considered to be a reservoir for zoonotic parasites, and the transmission of parasites from cattle to human handlers has been indicated in Bangladesh and India [16,17].…”

Section: Introductionmentioning

confidence: 99%

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Potential Zoonotic Transmission of Giardia duodenalis between Children and Calves in Bangladesh

Karim

Siddiki

et al. 2023

Transboundary and Emerging Diseases

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Giardia duodenalis is a zoonotic protozoan parasite that causes gastrointestinal illness in humans and livestock. We studied the genetic diversity of G. duodenalis in children and calves from Bangladesh to determine its zoonotic potential. Fecal samples collected from children (299) and calves (699) were screened with nested PCR with primers targeting the ssu rRNA gene for G. duodenalis. Positive samples were further multilocus genotyped using the β-giardin (bg), glutamate dehydrogenase (gdh), and triose phosphate isomerase (tpi) genes. The overall infection rate of G. duodenalis was 21.1% (63/299) in children and 5.7% (40/699) in calves. There were no significant differences in infection with G. duodenalis among age groups, sex, and study areas in children and calves. Multilocus genotyping (MLG) of human G. duodenalis identified zoonotic assemblages A (34.0%, 18/53) and B (50.9%, 27/53) and a so-called ruminant-specific assemblage E (11.3%, 6/53), as well as two mixed assemblages, B/D (1/53) and B/E (1/53). Assemblage E predominated in calves (82.3%, 28/34), followed by assemblages A (11.8%, 4/34) and B (5.9%, 2/34). Overall, zoonotic assemblages A, B, and E were found in 6.0% (18/299), 9.0% (27/299), and 2.0% (6/299) of the children’s stool samples, respectively, and 0.6% (4/699), 0.3% (2/699), and 4.0% (28/699) of the calf fecal samples, respectively. Although there was a difference in the distribution of subassemblages in humans (mostly AII) and calves (mostly AI), the zoonotic assemblages A, B, and E present in both children and calves suggest the potential for zoonotic transmission of G. duodenalis. This molecular study highlights the fact that G. duodenalis infections were common in the study areas, with potential zoonotic transmission between children and calves, implying that cattle might play a role in G. duodenalis zoonotic transmission.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Potential Zoonotic Transmission of Giardia duodenalis between Children and Calves in Bangladesh

Karim

Siddiki

et al. 2023

Transboundary and Emerging Diseases

View full text Add to dashboard Cite

show abstract

“…Low prevalence is reported from the developed world, whereas in South East Asian countries the prevalence ranges from 42% in asymptomatic children to as high as 68% in children presenting with diarrheal illness. 1 Common infections include ascariasis, trichuriasis, giardiasis, coccidiosis (cryptosporidium, cyclospora), amebiasis, toxoplasmosis, and less commonly strongyloidiasis. The risk factors for initial infestation remain the same in oncology patients as in general population.…”

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confidence: 99%