Pathogens in Sepsis: Gram‐Negative Bacterial PAMPs and PRRs

Schromm, Andra B.; Alexander, Christian; Gutsmann, Thomas; Andrä, Jörg; Stamme, Cordula

doi:10.1002/9783527626151.ch5

Cited by 2 publications

(2 citation statements)

References 162 publications

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“…The innate reaction at the site of an infection must occur rapidly to control the infection locally. Toll-like receptors (TLRs) are activated by pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) (191,258). Phagocytosis, which involves phagocytic cells such as neutrophils (also called polymorphonuclear cells), is at the crossroad of the innate response with all the cascades implicated in sepsis (108,150,154,165,192,203).…”

Section: Beneficial Against Infectionmentioning

confidence: 99%

Selenocompounds and Sepsis: Redox Bypass Hypothesis for Early Diagnosis and Treatment: Part A—Early Acute Phase of Sepsis: An Extraordinary Redox Situation (Leukocyte/Endothelium Interaction Leading to Endothelial Damage)

Forceville

Antwerpen

Preiser

2021

Antioxidants & Redox Signaling

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Significance: Sepsis is a health disaster. In sepsis, an initial, beneficial local immune response against infection evolves rapidly into a generalized, dysregulated response or a state of chaos, leading to multiple organ failure. Use of life-sustaining supportive therapies creates an unnatural condition, enabling the complex cascades of the sepsis response to develop in patients who would otherwise die. Multiple attempts to control sepsis at an early stage have been unsuccessful.

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Section: Beneficial Against Infectionmentioning

confidence: 99%

Selenocompounds and Sepsis: Redox Bypass Hypothesis for Early Diagnosis and Treatment: Part A—Early Acute Phase of Sepsis: An Extraordinary Redox Situation (Leukocyte/Endothelium Interaction Leading to Endothelial Damage)

Forceville

Antwerpen

Preiser

2021

Antioxidants & Redox Signaling

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“…[28,29], generated by stressed host cells, or exogenous pathogen-associated molecular patterns (PAMPs) [30][31][32] are recognized as being capable of activating the pattern recognition receptors (PRRs) [33] of the immune cells and as promoting the synthesis of inflammation mediators. Thus, any kind of tissue damage (pathogens [34,35], CRT [8,9] etc.) can induce a local [27,36] and systemic inflammatory response through circulating mediators ( Fig.…”

Section: Deteriorating Evolution Of Systemic Inflammationmentioning

confidence: 99%

Sepsis in head and neck cancer patients treated with chemotherapy and radiation: Literature review and consensus

Mirabile

Numico²,

Russi

et al. 2015

Critical Reviews in Oncology/Hematology

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The reporting of infection/sepsis in chemo/radiation-treated head and neck cancer patients is sparse and the problem is underestimated. A multidisciplinary group of head and neck cancer specialists from Italy met with the aim of reaching a consensus on a clinical definition and management of infections and sepsis. The Delphi appropriateness method was used for this consensus. External expert reviewers then evaluated the conclusions carefully according to their area of expertise. The paper contains seven clusters of statements about the clinical definition and management of infections and sepsis in head and neck cancer patients, which had a consensus. Furthermore, it offers a review of recent literature in these topics

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Pathogens in Sepsis: Gram‐Negative Bacterial PAMPs and PRRs

Cited by 2 publications

References 162 publications

Selenocompounds and Sepsis: Redox Bypass Hypothesis for Early Diagnosis and Treatment: Part A—Early Acute Phase of Sepsis: An Extraordinary Redox Situation (Leukocyte/Endothelium Interaction Leading to Endothelial Damage)

Selenocompounds and Sepsis: Redox Bypass Hypothesis for Early Diagnosis and Treatment: Part A—Early Acute Phase of Sepsis: An Extraordinary Redox Situation (Leukocyte/Endothelium Interaction Leading to Endothelial Damage)

Sepsis in head and neck cancer patients treated with chemotherapy and radiation: Literature review and consensus

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