Pathologic and molecular features of screening low-dose computed tomography (LDCT)-detected lung cancer: A baseline and 2-year repeat study

Pelosi, Giuseppe; Sonzogni, Angelica; Veronesi, Giulia; Camilli, Elisa De; Maisonneuve, Patrick; Spaggiari, Lorenzo; Manzotti, Michela; Masullo, Michele; Taliento, Giulio; Fumagalli, Caterina; Bellomi, Massimo; Travis, William D.; Kadivar, Maryam; Viale, Giuseppe

doi:10.1016/j.lungcan.2008.03.012

Cited by 28 publications

(24 citation statements)

References 63 publications

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“…This is in line with the type of primary lung cancers that are discovered by LDCT ( Table 1) and in a previous study (18). Despite the small numbers of MPLC cases in our study that indicates need of further studies, two scenarios may be drawn.…”

Section: Discussionsupporting

confidence: 91%

“…Moreover uncertainties and intervening modifications of the staging system of lung cancer and unavailability of morphologic and genetic/molecular features hinder recollection of information about MPLC in previous reports of LDCT screening (and surgical series). In particular, multiple pulmonary nodules may have been considered stage III or IV tumors (18), and this may have led to under-reporting of cases of MPLC, especially in case of multifocal adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…Three consecutive 10 µm-thick sections were performed from the same blocks for molecular analysis. These were conducted by a mass spectrometry-based multiplex assay (MassArray technology, Sequenom, San Diego, CA) using the "Myriapod Lung Status" kit (Diatech Pharmacogenetics, AN, IT) capable of identifying the major mutations of the following genes: EGFR (exons 18,19,20,21) …”

Section: Supplementarymentioning

confidence: 99%

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Screen-detected multiple primary lung cancers in the ITALUNG trial

et al. 2018

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Occurrence of multiple primary lung cancers (MPLC) in individuals undergoing low-dose computed tomography (LDCT) screening has not been thoroughly addressed. We investigated MPLC in subjects recruited in the ITALUNG randomized clinical trial. Cases of cytologically/histologically proven MPLC detected at screening LDCT or follow-up CT were selected and pathologically re-evaluated according to the WHO 2015 classification. Overall 16 MPLC were diagnosed at screening LDCT (n=14, all present at baseline) or follow-up CT (n=2) in six subjects (4 in one subject, 3 in two and 2 in three subjects), representing 0.43% of the 1,406 screenees and 15.8% of the 38 subjects with at least one screen-detected primary lung cancer. MPLC included 9 adenocarcinomas in three subjects and a combination of 7 different tumour histotypes in three subjects. MPLC, mostly adenocarcinomas, are not uncommon in smokers and ex-smokers with at least one LDCT screen detected primary lung cancer.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Supplementarymentioning

confidence: 99%

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Screen-detected multiple primary lung cancers in the ITALUNG trial

et al. 2018

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“…Solitary pulmonary nodules (SPN) have become more prevalent and due to the increasing reports of peripheral lung adenocarcinoma, the management of SPNs is becoming more challenging [1][2][3]. New endoscopic techniques such as navigation bronchoscopy have improved diagnostic yield [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

A Novel Method for In Vivo Imaging of Solitary Lung Nodules Using Navigational Bronchoscopy and Confocal Laser Microendoscopy

Hassan¹,

Piton²,

Lachkar³

et al. 2015

Lung

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Solitary pulmonary nodules (SPN) have become increasingly prevalent and diagnostic management remains challenging. We demonstrate a novel technique in which probe-based confocal endomicroscopy (pCLE) could be performed to microimage SPN in vivo and in realtime. Two confocal wavelengths (488 and 660 nm with methylene blue (MB)) were used for elastin network and cellular imaging, respectively using pCLE in conjunction with r-EBUS and virtual navigation. In the first case, the 1-mm Alveoflex Ò was used to image a metastatic melanoma in a subcentimetric nodule in the right middle lobe. In the next case, a malignant 2-cm nodule in the posterior segment of the upper lobe was imaged using the smaller 0.6-mm Cholangioflex Ò . Lastly, we present a benign case revealing confocal characteristics of a nodular lipid pneumonitis. This reports for the first time the feasibility and utility of pCLE in vivo microimaging of SPN using either the Alveoflex or Cholangioflex miniprobes in addition to 660 nm/MB imaging.

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“…This is also the most frequent type of tumor detected in low-dose CT screening trials. [2] FNAC technique should be used early and more frequently to shorten the diagnostic interval and allow more prompt therapy for persistent lung lesions. [3] Present communication mentions a case of young, seemingly healthy, female patient suffering from pulmonary tuberculosis accompanied with lung adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Tuberculosis Accompanying Adenocarcinoma of Lung in a Young Female from India

Pal¹

2012

IOSR-JDMS

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Pathologic and molecular features of screening low-dose computed tomography (LDCT)-detected lung cancer: A baseline and 2-year repeat study

Cited by 28 publications

References 63 publications

Screen-detected multiple primary lung cancers in the ITALUNG trial

Screen-detected multiple primary lung cancers in the ITALUNG trial

A Novel Method for In Vivo Imaging of Solitary Lung Nodules Using Navigational Bronchoscopy and Confocal Laser Microendoscopy

Pulmonary Tuberculosis Accompanying Adenocarcinoma of Lung in a Young Female from India

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