2021
DOI: 10.1155/2021/7545091
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Pathologic Complete Response and Its Impact on Breast Cancer Recurrence and Patient’s Survival after Neoadjuvant Therapy: A Comprehensive Meta-Analysis

Abstract: Objective. Earlier research has illustrated prognostic significance of pathologic complete response (pCR) in neoadjuvant therapy (NAT) for breast cancer, whereas correlation between treatment after achieving pCR and survival improvement remains underexplored. We attempted to measure the relation between pCR achieved after NAT and breast cancer recurrence or patient’s survival. Methods. We searched PubMed, EMBASE, Web of Science, and The Cochrane Library databases to find relevant articles from their inception … Show more

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Cited by 17 publications
(17 citation statements)
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“…In addition to race, molecular subtypes, access to care and other factors could contribute to different outcomes. OS was also signi cantly associated with pCR, consistent with multiple clinical trials demonstrating improved breast cancer outcomes in patients who achieve pCR, with prognostic value greatest for aggressive tumor subtypes [44- 49,59].…”
Section: Overall Survivalsupporting
confidence: 74%
“…In addition to race, molecular subtypes, access to care and other factors could contribute to different outcomes. OS was also signi cantly associated with pCR, consistent with multiple clinical trials demonstrating improved breast cancer outcomes in patients who achieve pCR, with prognostic value greatest for aggressive tumor subtypes [44- 49,59].…”
Section: Overall Survivalsupporting
confidence: 74%
“…Family history was positive only in 5,5% in luminal A,10,8% in luminal B with no significant difference, although family history of breast carcinoma is one of the major risk factors, about (five -ten%) cases of breast carcinoma are associated with a family history [19].…”
Section: Discussionmentioning
confidence: 89%
“…To assess the applicability of DIPK in clinical treatment, we conducted tests using three datasets [ 28 ] of breast cancer patients with annotated pCR status to paclitaxel treatment, namely GSE25055, GSE32646 and GSE20194. pCR is defined as the absence of any invasive cancer in breast cancer patients following the completion of neoadjuvant chemotherapy [ 63 , 64 ]. The samples in each dataset were categorized into two groups based on treatment annotations: the pCR group and the RD or nCR group.…”
Section: Resultsmentioning
confidence: 99%