Pathologic Features of Colorectal Carcinomas

Sayhan, Sevil; Kahraman, Dudu Solakoğlu

doi:10.1007/978-3-030-57273-0_23

Cited by 2 publications

(2 citation statements)

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“…Ras proteins are tiny guanosine triphosphatases (GTPases) to which the KRAS and BRAF genes belong. Through the GTPase cascade, they govern a variety of intracellular activities such as proliferation, differentiation, immune response, and survival rate [ 10 ]. The understanding of genetic alterations (such as in KRAS and BRAF mutations) in metastatic CRC (mCRC) via the use of gene profiling can be a catch point in explaining the gene's resistance to antiepidermal growth factor receptor (EGFR) antibody management [ 11 ] and as a prognostic predictor in arresting the progress of CRC [ 12 ] [ 8 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…* Percentage of all samples, age is presented in years ((mean + SD/median (range/IQR)/range). HRMS: high resolution melting-(HRM-) sequencing; HRMA/P: high resolution melting assay/pyrosequencing; PNAM/PCR and PNAM/PCR/S: peptide nucleic acid-mediated polymerase chain reaction/sequencing; IHC: immunohistochemistry; SS: Sanger sequencing 10. BioMed Research International…”

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A Systematic Review and Meta-analysis on the Occurrence of Biomarker Mutation in Colorectal Cancer among the Asian Population

Afolabi

Salleh

Zunita

et al. 2022

BioMed Research International

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Globally, colorectal carcinoma (CRC) is the third most common cancer and the third major cause of cancer-related death in both sexes. KRAS and BRAF mutations are almost mutually exclusively involved in the pathogenesis of CRC. Both are major culprits in treatment failure and poor prognosis for CRC. Method. A systematic review and meta-analysis of various research was done following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. This trial is registered with PROSPERO CRD42021256452. The initial search included 646 articles; after the removal of noneligible studies, a total of 88 studies was finally selected. Data analysis was carried out using OpenMeta Analyst and Comprehensive Meta-Analysis 3.0 (CMA 3.0) software to investigate the prevalence of KRAS and BRAF mutations among patients with CRC in Asia. Results. The meta-analysis comprises of 25,525 sample sizes from Asia with most being male 15,743/25525 (61.7%). Overall prevalence of KRAS mutations was (59/88) 36.3% (95% CI: 34.5-38.2) with I 2 = 85.54 % ( P value < 0.001). In 43/59 studies, frequency of KRAS mutations was majorly in codon 12 (76.6% (95% CI: 74.2–78.0)) and less in codon 13 (21.0% (95% CI: 19.1-23.0)). Overall prevalence of BRAF mutations was 5.6% (95% CI: 3.9-8.0) with I 2 = 94.00 % ( P value < 0.001). When stratified according to location, a higher prevalence was observed in Indonesia (71.8%) while Pakistan has the lowest (13.5%). Conclusion. Total prevalence of KRAS and BRAF mutations in CRC was 36.6% and 5.6%, respectively, and the results conformed with several published studies on KRAS and BRAF mutations.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

A Systematic Review and Meta-analysis on the Occurrence of Biomarker Mutation in Colorectal Cancer among the Asian Population

Afolabi

Salleh

Zunita

et al. 2022

BioMed Research International

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MALAT1-related signaling pathways in colorectal cancer

Jin

et al. 2022

Cancer Cell Int

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Colorectal cancer (CRC) is one of the most lethal and prevalent solid malignancies worldwide. There is a great need of accelerating the development and diagnosis of CRC. Long noncoding RNAs (lncRNA) as transcribed RNA molecules play an important role in every level of gene expression. Metastasis‐associated lung adenocarcinoma transcript‐1 (MALAT1) is a highly conserved nucleus-restricted lncRNA that regulates genes at the transcriptional and post-transcriptional levels. High expression of MALAT1 is closely related to numerous human cancers. It is generally believed that MALAT1 expression is associated with CRC cell proliferation, tumorigenicity, and metastasis. MALAT1 by targeting multiple signaling pathways and microRNAs (miRNAs) plays a pivotal role in CRC pathogenesis. Therefore, MALAT1 can be a potent gene for cancer prediction and diagnosis. In this review, we will demonstrate signaling pathways associated with MALAT1 in CRC.

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Pathologic Features of Colorectal Carcinomas

Cited by 2 publications

References 88 publications

A Systematic Review and Meta-analysis on the Occurrence of Biomarker Mutation in Colorectal Cancer among the Asian Population

A Systematic Review and Meta-analysis on the Occurrence of Biomarker Mutation in Colorectal Cancer among the Asian Population

MALAT1-related signaling pathways in colorectal cancer

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