Pathologic significance of immunoglobulin G4–positive plasma cells in extrahepatic cholangiocarcinoma

Kimura, Yasushi; Harada, Kenichi; Nakanuma, Yasuni

doi:10.1016/j.humpath.2012.03.001

Cited by 37 publications

(25 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the literature, the association of IgG4‐RSD with tumor is reported in a limited number of documents . However, the relationship between cancer‐related immunity and IgG4 antibody reaction has yet to be fully understood . In recent years, studies on the effect of IgG4 (+) cells on cancer tissue were published .…”

Section: Discussionmentioning

confidence: 99%

The role of IgG4 (+) plasma cells in the association of Hashimoto's thyroiditis with papillary carcinoma

Taşlı

Özkök

Argon

et al. 2014

APMIS

View full text Add to dashboard Cite

Hashimoto's thyroiditis (HT) is considered to be a risk factor for the formation of papillary carcinoma. The association of IgG4-related sclerosing disease with tumor is reported to be as sporadic cases in many organs. In this study, it was intended to re-classify the HT diagnosed cases on the basis of the existence of IgG4 (+) plasma cells; to investigate the clinicopathologic and histopathologic features of the both groups; and in addition, to evaluate the papillary carcinoma prevalence in IgG4 (+) and IgG4 (-) HT cases as well as the prognostic parameters between these groups. Totally 59 cases between the years 2008-2013, 29 of which contain Hashimoto thyroiditis diagnosis in total thyroidectomy materials, and 30 of which contain the diagnosis of HT+papillary carcinoma, were included in the study. The materials were immunohistochemically applied IgG and IgG4; and the cases were classified in two groups as IgG4-positive HT and IgG4-negative HT containing cases, on the basis of IgG4/IgG rate. All histopathologic and clinicopathologic parameters between these two groups, as well as their association with papillary carcinoma were investigated. Thirty eight (64.4%) of total 59 cases were NonIgG4 thyroiditis, and 21 (35.5%) were IgG4 thyroiditis. Tumors were detected in 14 (36.8%) of the NonIgG4 thyroiditis cases, and in 16 (76.1%) of the IgG4 thyroiditis cases. The association of IgG4 thyroiditis with tumor is statistically significant (p < 0.004). Multifocality was found to be at a higher rate in IgG4 thyroiditis cases. Perithyroidal extension was detected in six of the cases with tumor, and five of the six cases were IgG4 thyroiditis cases. The association of IgG4 (+) HT cases with increased papillary carcinoma prevalence is suggestive of that IgG4 (+) plasma cells can play a role in carcinogenesis in papillary carcinomas developed in HTs, without a chronic sclerosing ground. In addition, although the number of cases is limited, the high-association of IgG4 (+) plasma cells with adverse prognostic parameters such as multifocality and extrathyroidal extension is attention-grabbing. To render these possibilities evaluable, studies to be carried out with larger case series are needed.

show abstract

Section: Discussionmentioning

confidence: 99%

The role of IgG4 (+) plasma cells in the association of Hashimoto's thyroiditis with papillary carcinoma

Taşlı

Özkök

Argon

et al. 2014

APMIS

View full text Add to dashboard Cite

show abstract

“…An IgG4-positive lymphoplasmacytic infiltrate has been shown to be present in 52% of intrabiliary biopsies from patients with IgG4-related sclerosing cholangitis [22] and, although such an infiltrate may also be present in cholangiocarcinoma [23], it may assist in the diagnosis of IgG4-related sclerosing cholangitis within the context of current diagnostic criteria. Recently, cholangioscopic appearance has also been reported to aid the diagnosis of IgG4-related sclerosing cholangitis, which is characterized by the presence of dilated and tortuous vessels [13].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic utility of single-user peroral cholangioscopy in sclerosing cholangitis

Kalaitzakis

Sturgess

Kaltsidis

et al. 2014

Scandinavian Journal of Gastroenterology

View full text Add to dashboard Cite

show abstract

“…In fact, approximately 43% of bile duct carcinomas are associated with more than 10 IgG4 þ plasma cells, the threshold commonly used to diagnose IgG4-related sclerosing cholangitis. 35,36 An IgG4 to IgG ratio of more than 40% provides an additional level of security. Unfortunately, immunoperoxidase preparations performed on biopsy samples are often associated with significant background staining, a statement that particularly applies to the IgG stain.…”

Section: Bile Duct Biopsy In Igg4-related Sclerosing Cholangitismentioning

confidence: 99%

IgG4-Related Disease of the Gastrointestinal Tract: A 21st Century Chameleon

Deshpande

2015

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

Context Immunoglobulin G4 (IgG4)–related disease is a systemic fibroinflammatory disease capable of affecting virtually any organ. Although the pancreas and hepatobiliary system are commonly affected, involvement of the tubular gut is unusual. The pancreatic manifestations of this disease (autoimmune pancreatitis) often mimic pancreatic carcinoma, whereas the hepatobiliary manifestations are mistaken for cholangiocarcinoma or primary sclerosing cholangitis. The characteristic histologic features include a dense lymphoplasmacytic infiltrate, storiform-type fibrosis, and obliterative phlebitis. An increase in IgG4+ plasma cells and an IgG4 to IgG ratio of more than 40% are considered obligatory components of the diagnostic algorithm. Objective To review the challenges associated with the diagnosis of IgG4-related disease of the gastrointestinal tract. Data Sources A review of pertinent literature, along with the author's personal experience, based on institutional and consultation materials. Conclusion The complete spectrum of histologic changes is seldom captured in a biopsy specimen, and thus, the histopathology findings are best interpreted within the overall clinical context. Increased IgG4+ plasma cells are identified in a variety of benign and malignant diseases of the gastrointestinal tract.

show abstract

Pathologic significance of immunoglobulin G4–positive plasma cells in extrahepatic cholangiocarcinoma

Cited by 37 publications

References 31 publications

The role of IgG4 (+) plasma cells in the association of Hashimoto's thyroiditis with papillary carcinoma

The role of IgG4 (+) plasma cells in the association of Hashimoto's thyroiditis with papillary carcinoma

Diagnostic utility of single-user peroral cholangioscopy in sclerosing cholangitis

IgG4-Related Disease of the Gastrointestinal Tract: A 21st Century Chameleon

Contact Info

Product

Resources

About