2017
DOI: 10.1371/journal.pone.0184161
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Pathological alterations in liver injury following congestive heart failure induced by volume overload in rats

Abstract: Heart failure has emerged as a disease with significant public health implications. Following progression of heart failure, heart and liver dysfunction are frequently combined in hospitalized patients leading to increased morbidity and mortality. Here, we investigated the underlying pathological alterations in liver injury following heart failure. Heart failure was induced using a modified infrarenal aortocaval fistula (ACF) in male Wistar rats. Sham operated and ACF rats were compared for their morphometric a… Show more

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Cited by 16 publications
(10 citation statements)
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“…Intriguingly, organ/body weight indices of the liver and kidney were not significantly altered in ACF rats which may be due to the large AV fistula itself that affects organ perfusion preventing it from increasing organ weight. Nonetheless, both organs showed overt histopathological changes in the liver [45] and kidney [46], as has been previously published. Secondly, this study was conducted to assess the indirect adverse opioidergic effects in cardiac volume overload.…”
Section: Discussionsupporting
confidence: 81%
“…Intriguingly, organ/body weight indices of the liver and kidney were not significantly altered in ACF rats which may be due to the large AV fistula itself that affects organ perfusion preventing it from increasing organ weight. Nonetheless, both organs showed overt histopathological changes in the liver [45] and kidney [46], as has been previously published. Secondly, this study was conducted to assess the indirect adverse opioidergic effects in cardiac volume overload.…”
Section: Discussionsupporting
confidence: 81%
“…Sections were scanned using the Mirax Desk and observed at 20-times magnification using the Mirax viewer (Carl Zeiss MicroImaging, Germany). Fibrosis was assessed in four randomly chosen sections per rat, as previously described [ 25 , 26 ]. The area of collagen deposition was outlined and quantified using an automated image analysis program (AxioVision 4.6, Carl Zeiss MicroImaging, Germany).…”
Section: Methodsmentioning
confidence: 99%
“…11) In heart failure patients, centrilobular congestion, necrosis, inflammation, sclerosis, fibrosis, and regenerative hyperplasia are pathologically confirmed. [12][13][14] The fibrosis-4 index has been reported to be useful for predicting prognosis in patients with heart failure. 11,15) PH-LHD causes more severe symptoms and a worse prognostic impact, compared with left-sided heart failure with normal pulmonary artery pressure.…”
mentioning
confidence: 99%