Pathological and anatomical abnormalities affecting buffalo cows reproductive tracts in Mosul

Azawi, O. I.; Ali, A. J.; Lazim, E. H.

doi:10.33899/ijvs.2008.5715

Cited by 15 publications

(3 citation statements)

References 16 publications

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“…To resume normal reproductive functions, the uterus needs to clear the microbial contamination during postpartum. If animals cannot clear the microbial contamination from the uterus, the uterine layers would be inflamed and lead to post-parturient disorders, such as metritis, submetritis, endometritis and mastitis 4 . Due to infection, the uterine wall, its underlying glandular tissues and the muscular layer get inflamed, and such inflammation is called metritis 13 .…”

Section: Postpartum Periodmentioning

confidence: 99%

“…Due to infection, the uterine wall, its underlying glandular tissues and the muscular layer get inflamed, and such inflammation is called metritis 13 . Endometritis is the inflammation of functional inner lining of the uterus 4 14 . Both metritis and endometritis generally do not show the systemic signs 15 .…”

Section: Postpartum Periodmentioning

confidence: 99%

“…Persistent uterine infection reduces immune efficiency 3 in buffalo cows. Consequently, the uterine functions such as harbouring spermatozoa and proper embryonic development would be compromised 4 . In addition, the uterine infection affects hypothalamic-pituitary-ovarian axis, thereby dysregulates the ovarian follicle development, ovulation and corpus luteal function 5 6 7 .…”

Section: Introductionmentioning

confidence: 99%

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Postpartum uterine infection & ovarian dysfunction

Dahiya

Kumari

Rani

et al. 2018

Indian Journal of Medical Research

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Postpartum uterine infections such as metritis, endometritis and mastitis have been considered as underlying causes for ovarian dysfunction in mammals. Almost all mammals, particularly dairy animals are susceptible to postpartum uterine infections, resulting in impaired fertility and economic loss. One of the factors for low fertility in females is ovarian dysfunction, which is exhibited as impaired growth and function of ovarian follicles by the postpartum infection. Immune system of mammals provides a host defence mechanism against pathogenic microbes through the recognition of pathogen-associated molecular patterns (PAMPs) and forming inflammasomes. Like immune cells, ovarian granulosa cells also exhibit a similar pattern of cytokine gene expressions on exposure to PAMPs. Genome-wide transcriptomic approaches explored the molecular mechanisms underlying the immune function of buffalo granulosa cells during endotoxin exposure. Understanding the molecular mechanism of ovarian dysfunction due to uterine infection would be helpful to implement various strategies to handle the adverse effects of postpartum uterine disease on fertility by developing potential therapeutics. Therefore, this article focuses on key factors that are responsible for postpartum infection and particularly summarizes the molecular mechanism of infection underlying the ovarian dysfunction in dairy animals.

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Section: Postpartum Periodmentioning

confidence: 99%