Pathological aspects of so called "hilar cholangiocarcinoma"

Castellano-Megias, Victor M.; Andrés, Carolina Ibarrola-de; Colina-Ruizdelgado, F

doi:10.4251/wjgo.v5.i7.159

Cited by 34 publications

(35 citation statements)

References 68 publications

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“…The incidence of intra and extrahepatic CC in the literature has largely depended on how hilar CC, the commonest CC has been considered. 19 17 cases of hilar cholangiocarcinomas which we came across were not included in the present study. On the basis of gross morphology intrahepatic cholangiocarcinomas are classified into three subtypes: mass forming, periductal infiltrating and intraductal.…”

Section: Discussionmentioning

confidence: 99%

Surgical resection for hepatic space occupying lesions: a histopathological analysis

Vani¹,

Kachappilly²,

Geetha³

2017

Int J Res Med Sci

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Background: Hepatic resections are done for both neoplastic and non-neoplastic diseases of liver with malignancies constituting a major share of cases. The objective of this study was to assess the various neoplatic and non-neoplastic lesions in hepatic resection specimens and to categorize the various histopathological types of primary and secondary liver tumors.Methods: The study was conducted in the Department of Pathology, Academy of Medical sciences, Pariyaram. This was a hospital based study which included 79 patients who underwent hepatic resection for space occupying lesions over a period of 5 years from January 2012 to December 2016. IHC was performed in cases with diagnostic dilemma.Results: Of the 79 cases, there were 45 males and 34 females with the age range of 22-85 years. There were 70 neoplastic lesions out of which 11 were benign with 6 cavernous hemangiomas, 3 hepatic adenomas and one each of intraductal papillary neoplasm and mucinous cystic neoplasm. Among the 59 malignant lesions, hepatocellular carcinomas predominated followed by metastatic malignancies and cholangiocarcinomas. Of the metastatic malignancies, adenocarcinoma from gastrointestinal primary was the commonest followed by metastatic gastrointestinal stromal tumor.Conclusions: Liver is a frequent site for many neoplastic and non-neoplastic diseases with malignant neoplasms forming the major bulk. Non-neoplastic lesions like simple liver cysts and focal nodular hyperplasia showed female predominance while benign neoplasms like cavernous hemangioma and hepatic adenomas were seen exclusively in females. Of the malignant liver tumors, hepatocellular carcinoma was the commonest followed by metastatic malignancy, gastrointestinal tract being the commonest source of primary tumor.

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Section: Discussionmentioning

confidence: 99%

Surgical resection for hepatic space occupying lesions: a histopathological analysis

Vani¹,

Kachappilly²,

Geetha³

2017

Int J Res Med Sci

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“…Согласно классификации Все-мирной организации здравоохранения, основанной на степени дифференцировки клеток, аденокарциномы желчных протоков в зависимости от процентного соотно-шения железистых клеток в опухолевой ткани подразде-ляются на высоко-, умеренно-и низкодифференцирован-ные, что составляет 95, 40-94 и 5-39% желез соответ-ственно [1,7,8,10,18,24,27].…”

Section: хирургия 4 2015unclassified

“…Периневраль-ная инвазия является специфическим путем распростра-нения рака желчных протоков и представляет важный прогностический фактор. Распространение заболевания путем инвазии в прилежащие структуры ворот печени, в ветви воротной вены и печеночной артерии, прилегаю-щую паренхиму печени является характерным признаком ВХ [8,11,24].…”

Section: хирургия 4 2015unclassified

“…Склерозирующий тип диффузно инфильтрирует на протяжении стенки протока с образованием небольших слизистых выступов, он встречается наиболее часто. По данным литературы, папиллярная ВХ чаще резектабель-на, с лучшим прогнозом вследствие менее выраженного инвазивного роста [8,18,24,27].…”

Section: хирургия 4 2015unclassified

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View of the problem of Rlatskin tumor

Czhao¹,

Шевченко²,

Zharikov³

2015

Khir. Z. im. N.I. Pirogova

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Ключевые слова: опухоль Клатскина, факторы риска, классификация, диагностика, лечение, прогноз. Klatskin tumorarises from the common hepatic duct and its bifurcation the bile ducts and is the most common primary malignancy of the biliary tree. The location of the tumor and its close relationship with vascular structures at the hepatic hilum have resulted in a low resectability and high rate morbidity and mortality. Improvementof instrumental diagnostics and operative techniquesallowsto performextendedresectionand complexinterventions onthe liver, bile ductsand vascularstructuresat the hepatic hilum. The role ofchemoradiotherapyandphotodynamic therapyis not fullyunderstood. Thus, questions of treatmentandprognosis of the diseaseare remain relevantandrequire further study.

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“…Serrablo et al [9] have resumed surgical outcomes in HC: All these technical improvements have been achieved without significantly increasing morbidity and mortality [1][2][3] ; mortality in HC surgery currently ranges between 0% and 11.9% [3,5] . Prof. Castellano-Megías et al [10] have reviewed the importance of an adequate and minucius pathologic study of surgical specimens in HC.…”

Section: Editorialmentioning

confidence: 99%

Hilar Cholangiocarcinoma

Miyazaki

Itoh²,

Kimura³

et al. 2016

Principles of Hepatic Surgery

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EDITORIALHilar cholangiocarcinoma (HC) is a rare tumor (0.74-1.05 ×100000 inhabitants), representing 3% of gastrointestinal cancers [1,2] . It accounts for 2/3 of the tumors of the biliary tract [1] . Although HC is frequently discussed at surgical scientific meetings and arouses great interest, it has far fewer citations than other HPB cancers and several questions regarding the condition remain unanswered in the medical literature.Untreated, the prognosis of HC is very poor. Surgery is the only therapy that offers the possibility of cure but is technically very complex [1,3] . A few years ago, the number of patients operated and resected was very low, and 5-year survival was mediocre. With recent improvements in the therapeutic strategies applied by multidisciplinary teams comprising radiologists, gastroenterologists, surgeons and oncologists, survival rates in the different series currently range from 25% to 45% [3,4] . A group of experts devoted to HC (pathologists, gastroenterologists, radiologists, surgeons and oncologists) have reviewed and updated every open question in HC in this special issue focusing in the following areas of the management and treatment of patients with HC:Prof. Valls et al [5] has updated diagnostic methods in HC: Imaging methods have improved diagnostic sensitivity and specificity, especially for determining biliary and vascular involvement. These methods include multidetector computed tomography, Cholangio-magnetic resonance, percutaneous transhepatic cholangioscopy, positron emission tomography computed tomography and staging by laparoscopy reviewed by Prof. Rotellar et al [6] . Prof. Suarez-Munoz et al [7] have updated the classification/staging systems in HC: There have been several pro- AbstractHilar cholangiocarcinoma (HC) is a rare tumor. It accounts for 2/3 of the tumors of the biliary tract. Untreated, prognosis is very poor. Surgery is the only therapy that offers the possibility of cure but is technically very complex. With recent improvements in the therapeutic strategies applied by multidisciplinary teams, survival rates in the different series currently range from 25% to 45%. A group of experts devoted to HC (pathologists, gastroenterologists, radiologists, surgeons and oncologists) have reviewed and updated every open question in HC in a special issue. Key words: Cholangiocarcinoma; Hilar; Perihilar; Klatskin; Surgery; Cancer; Review Core tip: Most remarked avances are: imaging methods have improved diagnostic sensitivity and specificity, especially for determining biliary and vascular involvement; there have been several proposals to improve the classic Bismuth-Corlette classification; preand post-operative care; technical aspects trying to obtain a R0 resection: widespread use of liver resection, resection of segment I and venous and arterial resection, refinement of post-operative histology and adjuvant therapies.

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Pathological aspects of so called "hilar cholangiocarcinoma"

Cited by 34 publications

References 68 publications

Surgical resection for hepatic space occupying lesions: a histopathological analysis

Surgical resection for hepatic space occupying lesions: a histopathological analysis

View of the problem of Rlatskin tumor

Hilar Cholangiocarcinoma

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