Pathological characteristics of mediastinal masses in Sri Lanka 2017–2021: a retrospective observational study

Mathangasinghe, Y.; Pradeep, I. H. D. S.; Perera, S A U; Punchihewa, Ramani

doi:10.1183/23120541.00256-2022

Cited by 3 publications

(6 citation statements)

References 5 publications

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“…The third most common diagnosis found by the current study was thymoma, which accounted for 13.6% of all diagnoses. In contrast to our findings, a study conducted in Sri Lanka in 2022 discovered that the most common mass was a thymic lesion (31%), followed by lymphoma (18.2%) [ 9 ]. Another study found that most of the study participants were male [ 9 ], which supported our study results that most of the patients (70.5%) were male.…”

Section: Discussioncontrasting

confidence: 99%

“…In contrast to our findings, a study conducted in Sri Lanka in 2022 discovered that the most common mass was a thymic lesion (31%), followed by lymphoma (18.2%) [ 9 ]. Another study found that most of the study participants were male [ 9 ], which supported our study results that most of the patients (70.5%) were male. One more study by Bekele et al found similar results that about 67.1% of their study participants were male [ 10 ].…”

Section: Discussioncontrasting

confidence: 99%

“…The current study found that most of the mediastinal mass (93.2%) was present in the anterior compartment. A similar finding was found by Mathangasinghe et al, in 2022, in a study done in Sri Lanka, they diagnosed 55% of the patients with an anterior mediastinal mass [ 9 ]. One more study by Bekele et al found similar results: 61.6% of their study participants have an anterior mediastinal mass [ 10 ].…”

Section: Discussionsupporting

confidence: 82%

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Clinico-Pathological and Radiological Spectrum of Mediastinal Masses in a Tertiary Care Center: A Cross-Sectional Study

Shahana¹,

Ayub²,

Dhanasekar³

et al. 2023

Cureus

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Introduction The phrase “mediastinal mass” refers to a mass within the mediastinum. About 50% of all mediastinal masses, including teratoma, thymoma, lymphoma, and thyroid illness, are anterior mediastinal tumors. Data on the mediastinal mass in India are relatively sparse, especially in this region, compared to those from other countries. Mediastinal masses are very infrequent lesions that might occasionally present a diagnostic and therapeutic challenge to the doctor. The current study describes the socio-demographic characteristics, symptoms, diagnosis, and location of mediastinal mass among the study participants. Methodology We carried out a retrospective, cross-sectional study in a tertiary care center in Chennai for three years. We included patients with an age above 16 years who visited the tertiary care center in Chennai during the study period. We included all patients with a mediastinal mass diagnosed by CT scan, with or without signs and symptoms of mediastinal compression. Patients under the age of 16 and those with insufficient data were both excluded from the study. As per the universal sampling technique, we included all the patients who met the eligibility criteria during the study period (three years) as study subjects. By using the hospital records, we collected all data about the patients like socio-demographic data, presenting complaints, past history, x-ray findings, and co-morbidities. Similarly, we recorded blood parameters, pleural fluid parameters, and histopathological reports from the laboratory register. Results The mean age of the study participants was 41.11 years, with a high proportion of patients belonging to the age group of 21 to 30 years. Over 70% of the study participants were male. Only about 54.5% of the study participants had symptoms because of a mediastinal mass. The most common local symptom felt by the patients was dyspnea, followed by a dry cough. Weight loss was the most common symptom for the patients. Most study participants (47.7%) had seen a doctor within one month of the onset of symptoms. About 4.5% of the patients had pleural effusion, as diagnosed by x-ray. Most of the study participants had a mass in the anterior mediastinum, followed by the posterior mediastinum. Most of the participants (15.9%) had non-caseating granulomatous inflammation suggestive of sarcoidosis. Conclusion The most common tumor found in our study was lymphoma, which was followed by non-caseating granulomatous disease and thymoma. Anterior compartments are most commonly involved. We observed the most common presentation in the third decade of life with a male to female ratio of 2:1, with dyspnea being the most common symptom, followed by a dry cough. Our study found 4.5% of the patients had pleural effusion as a complication.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 82%

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Clinico-Pathological and Radiological Spectrum of Mediastinal Masses in a Tertiary Care Center: A Cross-Sectional Study

Shahana¹,

Ayub²,

Dhanasekar³

et al. 2023

Cureus

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“…Notably, it serves as the primary referral institution for lung tumor patients in Sri Lanka, enabling us to assemble a nationally representative patient sample. 5 We included all patients who had their lung tumors analyzed through histopathological examination. We Yasith Mathangasinghe and Sameera Wijayawardhana contributed equally to this study.…”

Section: Abstract Adenocarcinoma Demographics Epidemiology Lung Neopl...mentioning

confidence: 99%

“…NHRD stands as the exclusive tertiary care center dedicated to respiratory diseases in the country, offering specialized diagnosis and treatment. Notably, it serves as the primary referral institution for lung tumor patients in Sri Lanka, enabling us to assemble a nationally representative patient sample 5 . We included all patients who had their lung tumors analyzed through histopathological examination.…”

Section: Type Of Tumor Frequency (N) and Percentage (%) Of Tumors (N ...mentioning

confidence: 99%

Pathological characteristics of lung tumors in Sri Lanka 2017–2021

Mathangasinghe,

Wijayawardhana,

Perera

et al. 2024

Thoracic Cancer

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The prevalence of lung cancer is steadily increasing globally, and it is projected to become the second most prevalent cancer in men by 2030. Lung cancer is the leading cause of cancer‐related deaths worldwide, accounting for approximately 3.61% of total fatalities. Despite its significant impact, many Asian countries, including Sri Lanka, lack precise data on the epidemiological patterns of lung tumors. This study pioneers a comprehensive exploration in Sri Lanka, delving into the demographic and clinicopathological characteristics of lung cancer patients. The study included 733 consecutive patients with lung tumors from 2017 to 2021, with a median age of 59 years. The most common site of tumors was the right lower lobe and left upper lobes. Adenocarcinoma was the most prevalent histopathological type of primary malignant lung tumors, while colorectal adenocarcinomas were the most common cause of metastatic deposits in the lungs. The most common benign tumor was hamartoma. Significantly, our findings unveiled associations between patient demographics and tumor types, underscoring the importance of factoring in age and gender in diagnostic assessments. Notably, the absence of a dedicated lung cancer screening program in Sri Lanka underscores the critical reliance on clinical suspicion and accurate diagnostic methods.

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Clinicopathological study of primary mediastinal masses presented to a specialized hospital in Baghdad

KHUDAIR,

ALATROOSHI

2024

Chirurgia

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Pathological characteristics of mediastinal masses in Sri Lanka 2017–2021: a retrospective observational study

Cited by 3 publications

References 5 publications

Clinico-Pathological and Radiological Spectrum of Mediastinal Masses in a Tertiary Care Center: A Cross-Sectional Study

Clinico-Pathological and Radiological Spectrum of Mediastinal Masses in a Tertiary Care Center: A Cross-Sectional Study

Pathological characteristics of lung tumors in Sri Lanka 2017–2021

Clinicopathological study of primary mediastinal masses presented to a specialized hospital in Baghdad

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