Pathological Comparison of Rat Pulmonary Models Induced by Silica Nanoparticles and Indium-Tin Oxide Nanoparticles

Guan, Yi; Liu, Nan; Yu, Yan; Zhang, Qiang; Chang, Meiyu; Wang, Yongheng; Yao, Sanqiao

doi:10.2147/ijn.s380259

Cited by 9 publications

(8 citation statements)

References 19 publications

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“…The results of this study are in line with studies showing the accumulation of bronchial collagen in rats due to other toxic substances, namely sulphur mustard 29 and silica nanoparticles. (31) Based on the results of this study, research is needed to prove on the molecular level that low-dose filtered kretek cigarette smoke, at doses of 1 stick/day or 2 sticks/ day for 30 days has affected the genes that control collagen accumulation resulting in bronchial fibrosis in the rats. This is consistent with the results of research showing that exposure to cigarette smoke controls the gene expression of heat shock protein, (45)(46)(47) collagen type I, (31) collagen type III, (31,48) DNA methylation and histone modifications.…”

Section: Discussionmentioning

confidence: 99%

“…(31) Based on the results of this study, research is needed to prove on the molecular level that low-dose filtered kretek cigarette smoke, at doses of 1 stick/day or 2 sticks/ day for 30 days has affected the genes that control collagen accumulation resulting in bronchial fibrosis in the rats. This is consistent with the results of research showing that exposure to cigarette smoke controls the gene expression of heat shock protein, (45)(46)(47) collagen type I, (31) collagen type III, (31,48) DNA methylation and histone modifications. (49) In addition to cigarette smoke, fibrosis in the lung tissue of Sprague-Dawley rats can also be caused by exposure to bleomycin and lipopolysaccharide.…”

Section: Discussionmentioning

confidence: 99%

“…(28) It has been demonstrated that inhalation of toxic compounds causes inflammation, (29,30) progressive lung injury, (29) and fibrosis in the rat. (18,29,31) As with COPD, morphometric measurements have been made in lung cystic fibrosis. (32) It has been demonstrated that unfiltered cigarettes were smoked at a lower rate during the trial than filtered cigarettes (p<0.05).…”

Section: Introductionmentioning

confidence: 99%

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Effects of low-dose filtered kretek cigarette smoke on bronchial smooth muscle in male Sprague-Dawley rats

Tjahyadi,

Parwanto,

Sisca

et al. 2023

Univ Med

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BackgroundKretek cigarettes contain less nicotine and tar than conventional cigarettes. Exposure to cigarette smoke occurs mainly in the respiratory tract, resulting in histometric changes. The aim of this study was to evaluate the effect of filtered kretek cigarette smoke on bronchial histometric measurements in male Sprague-Dawley rats. MethodsAn experimental laboratory study was conducted involving 18 male Sprague-Dawley rats, aged 2-3 months, ranging from 150 to 250 grams in body weight. They were randomized into group 1 (controls) and experimental groups 2 and 3. Group 2 was exposed to filtered cigarette smoke at a dose of 1 stick/day and group 3 to 2 sticks/day. Treatment time for all groups was 30 days. Observation of bronchial histometric measurements of the lumen include, length, width, area, and perimeter. In addition, the bronchial mucosal and smooth muscle layers were also measured. The one way-ANOVA test was used to analyze the data. ResultsThe mean area and mean perimeter of the bronchial lumen of the rats were significantly greater in group 1 than in groups 2 and 3 (p=0.000). The mean bronchial smooth muscle area of the rats in group 1 was smaller than the mean in group 2, which was in turn smaller than the mean in group 3 (p=0.000). Apparently the rats in the treatment groups had undergone bronchoconstriction. ConclusionExposure to filtered kretek cigarette smoke at a dose of 1 stick/day as well as 2 sticks/day for 30 days caused bronchial mucosal hyperplasia and bronchoconstriction in male rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of low-dose filtered kretek cigarette smoke on bronchial smooth muscle in male Sprague-Dawley rats

Tjahyadi,

Parwanto,

Sisca

et al. 2023

Univ Med

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“…And it was found that prolonged exposure to nanosilica caused interstitial fibrosis in rat lungs, unlike the silicotic nodules induced by micron silica (Zhang et al, 2014). A recent study also showed granulomatous inflammation and large fibrotic nodules in the lung tissue of rats exposed to nanosilica (Guan et al, 2022). However, it is unclear whether there are such differences in the pulmonary toxicity between cigarette filter silica and natural crystalline silica.…”

Section: Discussionmentioning

confidence: 99%

Adverse effects of cigarette filter silica on lungs: Comparison with natural crystalline silica particles

Kang,

Li,

Wang

et al. 2023

Toxicol Ind Health

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As a common additive in cigarette filters, nanosilica has been implemented to reduce the release of harmful substances in cigarette smoke. However, the potential risk of occupational exposure for cigarette factory workers is unknown. We collected physical examination data from 710 cigarette factory workers to evaluate the adverse effects of cigarette filter silica exposure. We also established mouse models induced by cigarette filter silica and crystalline silica separately to compare the lung inflammation, pulmonary function, apoptosis, and fibrosis of the two models. Workers in the rolling and packing workshop exposed to cigarette filter silica had a higher rate of abnormal lung function (17.75%) than those in the cutting workshop (0.87%). Animal experiments showed that compared with the same dose of crystalline silica, cigarette filter silica resulted in higher levels of inflammatory factors in the bronchoalveolar lavage fluid (BALF) of mice at day 7, and lower levels of total lung capacity (TLC), inspiratory capacity (IC), vital capacity (VC), and forced vital capacity (FVC) in mice at day 28. Additionally, both exposed groups of mice showed increased levels of caspase 3, collagen I (Col-Ⅰ), α-smooth muscle actin (α-SMA) and hydroxyproline (HYP) in the lungs, as well as collagen accumulation and fibrous nodules at day 28, with no significant difference between the two groups. The results suggested that cigarette filter silica caused more severe early lung inflammation and late ventilation impairment than the same dose of crystalline silica. In the future, we need to pay more attention to nanosilica protection in cigarette factories to prevent pulmonary dysfunction in workers.

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“…Compared with SiO 2 ‐NPs‐exposed rats, TiO 2 ‐NPs‐exposed rats exhibited significantly severe pulmonary alveolar proteinosis pathological changes, lower fibrosis, and higher levels of inflammatory biomarkers. However, SiO 2 ‐NPs‐exposed rats had more severe fibrotic lesions and more severe granulomas than TiO 2 ‐NPs‐exposed rats 139 . In summary, NPs benefit from their physical properties and can easily enter the systemic circulation through the respiratory system through the air–blood barrier, causing serious adverse effects on the respiratory system.…”

Section: Toxic Effects Of Nps On Healthmentioning

confidence: 97%

Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

Xuan

Zhao

Skonieczna

et al. 2023

MedComm

110

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Nanoparticles (NPs) have become one of the most popular objects of scientific study during the past decades. However, despite wealth of study reports, still there is a gap, particularly in health toxicology studies, underlying mechanisms, and related evaluation models to deeply understanding the NPs risk effects. In this review, we first present a comprehensive landscape of the applications of NPs on health, especially addressing the role of NPs in medical diagnosis, therapy. Then, the toxicity of NPs on health systems is introduced. We describe in detail the effects of NPs on various systems, including respiratory, nervous, endocrine, immune, and reproductive systems, and the carcinogenicity of NPs. Furthermore, we unravels the underlying mechanisms of NPs including ROS accumulation, mitochondrial damage, inflammatory reaction, apoptosis, DNA damage, cell cycle, and epigenetic regulation. In addition, the classical study models such as cell lines and mice and the emerging models such as 3D organoids used for evaluating the toxicity or scientific study are both introduced. Overall, this review presents a critical summary and evaluation of the state of understanding of NPs, giving readers more better understanding of the NPs toxicology to remedy key gaps in knowledge and techniques.

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Pathological Comparison of Rat Pulmonary Models Induced by Silica Nanoparticles and Indium-Tin Oxide Nanoparticles

Cited by 9 publications

References 19 publications

Effects of low-dose filtered kretek cigarette smoke on bronchial smooth muscle in male Sprague-Dawley rats

Effects of low-dose filtered kretek cigarette smoke on bronchial smooth muscle in male Sprague-Dawley rats

Adverse effects of cigarette filter silica on lungs: Comparison with natural crystalline silica particles

Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

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