Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment

Zarrer, Jennifer; Haider, Marie-Therese; Smit, Daniel J; Taipaleenmäki, Hanna

doi:10.3390/biom10020337

Cited by 41 publications

(33 citation statements)

References 124 publications

(216 reference statements)

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“…The metastatic bone microenvironment provides many growth factors for carcinoma such as vascular endothelial growth factor (VEGF), bone morphogenic proteins and interleukin. 8 VEGF is associated with migration and proliferation of vascular smooth muscle cells and is also considered to be key factor in PTTM. 9,10 Change of microenvironments in bone marrow niches and in pulmonary vascular caused by PTTM and DCBM may interact with each other, and accelerate the tumor embolism.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary tumor thrombotic microangiopathy associated with extramammary Paget's disease: An autopsy case report

Oyama

Nishida

Kondo

et al. 2020

Pathology International

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Pulmonary tumor thrombotic microangiopathy (PTTM) is histologically characterized by micro tumor cell embolism and intimal fibrocellular proliferation of pulmonary arteries or arterioles. We report a secondary case of PTTM associated with extramammary Paget's disease (EMPD). The patient was a 72‐year‐old man with exertional dyspnea. Clinical examinations found he had pulmonary hypertension and multiple osteolytic lesions of vertebra. Cytological analysis of pulmonary wedge artery sample detected malignant cells and he was dead before treatment was started. Multiple tumor embolisms (>17) were identified in pulmonary arteries or arterioles at autopsy, consistent with PTTM. Metastatic nodules were found in liver and lymph node. Furthermore, disseminated carcinomatosis of the bone marrow (DCBM) was seen. Immunostaining results pointed out that tumor cells possessed mammary gland phenotype. He had 4‐years history of EMPD in the left axilla without recurrence, and immunohistochemistry results were the same as the autopsy specimen. Thus, we diagnosed the primary site of PTTM to be EMPD. Our case highlights the usefulness of the recent proposed classification of PTTM, potential association between PTTM and DCBM, and the necessity for long‐term follow‐up in EMPD. EMPD can rarely cause PTTM to manifest as a paraneoplastic syndrome.

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Section: Discussionmentioning

confidence: 99%

Pulmonary tumor thrombotic microangiopathy associated with extramammary Paget's disease: An autopsy case report

Oyama

Nishida

Kondo

et al. 2020

Pathology International

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“…Indeed, bone metastatic breast cancer cells prefer to colonize adjacent to the endothelial cells and even around the vessels ( 141 ). High vascularization supports cancer growth by providing nutrients and growth factors ( 7 ).…”

Section: Bmas and Mechanisms Responsible For Macrometastasis And Outgmentioning

confidence: 99%

“…The bone marrow microenvironment comprises of multiple cell types, such as osteoblasts, osteoclasts, hematopoietic cells, mesenchymal stem cells, endothelial cells, and adipocytes. All of these cells play indispensable roles in the maintenance of bone homeostasis ( 7 ). Furthermore, they might provide a supportive niche for metastatic cancer cells.…”

Section: Introductionmentioning

confidence: 99%

“…The contribution of stromal cells including osteoclasts, osteoblasts, and inflammatory cells to bone metastasis of breast cancer has been extensively described ( 7 ). Occupying the highest proportion of the bone marrow, however, the comprehensive roles of bone marrow adipocytes (BMAs) in the metastatic microenvironment are still poorly understood ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

“…For a long time, BMAs have been described to fill the interspace of the bone marrow. Nevertheless, recently BMAs are demonstrated to function as an endocrine organ ( 7 ). BMAs can secrete various bioactive peptides or proteins.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bone Marrow Adipocytes, Adipocytokines, and Breast Cancer Cells: Novel Implications in Bone Metastasis of Breast Cancer

Liu

Zhao

2020

Front. Oncol.

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Accumulating discoveries highlight the importance of interaction between marrow stromal cells and cancer cells for bone metastasis. Bone is the most common metastatic site of breast cancer and bone marrow adipocytes (BMAs) are the most abundant component of the bone marrow microenvironment. BMAs are unique in their origin and location, and recently they are found to serve as an endocrine organ that secretes adipokines, cytokines, chemokines, and growth factors. It is reasonable to speculate that BMAs contribute to the modification of bone metastatic microenvironment and affecting metastatic breast cancer cells in the bone marrow. Indeed, BMAs may participate in bone metastasis of breast cancer through regulation of recruitment, invasion, survival, colonization, proliferation, angiogenesis, and immune modulation by their production of various adipocytokines. In this review, we provide an overview of research progress, focusing on adipocytokines secreted by BMAs and their potential roles for bone metastasis of breast cancer, and investigating the mechanisms mediating the interaction between BMAs and metastatic breast cancer cells. Based on current findings, BMAs may function as a pivotal modulator of bone metastasis of breast cancer, therefore targeting BMAs combined with conventional treatment programs might present a promising therapeutic option.

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Microenvironment‐Responsive Targeted Nanomedicine for a Collaborative Integration of Tumor Theranostics and Bone Defect Repair

Wang,

Kang,

Zhang

et al. 2024

Adv Healthcare Materials

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Despite advancements in breast cancer treatment, bone metastases remain a significant concern for patients with advanced breast cancer. Current theranostics strategies face challenges in integrating tumor theranostics and bone formation. Herein, we developed an activatable targeted nanomedicine AuMnCO@BSA‐N3 (AMCBN) to enable a novel collaborative integration of second near‐infrared (NIR‐II) fluorescence imaging guided precise theranostics for breast cancer bone metastases and osteogenic microenvironment remolding. This strategy employed a chemical coordination between noble metal complex and metal carbonyl (MnCO). The surface modification of azide groups for enhanced tumor affinity through passive and active targeting. The initiated respondent behavior of AMCBN by tumor microenvironment (H2O2/acidity) accelerate the degradation of coordinated MnCO, resulting in a rapid release of multifunctional agents for efficient chemodynamic therapy (CDT)/gas synergistic therapy. Meanwhile, the exceptional bone‐binding properties enable the efficient and controlled release of Mn2+ ions and CO in the bone microenvironment, thereby facilitating the expression of osteogenesis‐related proteins and establishing a novel synchronous theranostics process for tumor‐bone repair.This article is protected by copyright. All rights reserved

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Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment

Cited by 41 publications

References 124 publications

Pulmonary tumor thrombotic microangiopathy associated with extramammary Paget's disease: An autopsy case report

Pulmonary tumor thrombotic microangiopathy associated with extramammary Paget's disease: An autopsy case report

Bone Marrow Adipocytes, Adipocytokines, and Breast Cancer Cells: Novel Implications in Bone Metastasis of Breast Cancer

Microenvironment‐Responsive Targeted Nanomedicine for a Collaborative Integration of Tumor Theranostics and Bone Defect Repair

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