Pathological Effects of Dietary Rapeseed Oils with High or Low Erucic Acid Content in Ducklings

Abdellatif, A.M.M.; Vles, R. O.

doi:10.3382/ps.0521932

Cited by 11 publications

(5 citation statements)

References 3 publications

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“…It should be noted, however, that other strains of rat, namely Chester Beatty (17,20) and Wistar (18), showed only a low incidence and/or severity of heart lesions which was not increased with the intake of LEAR oils. Similar results were observed with mice (18), pigs (21)(22)(23)(24)(25), monkeys (26,27), ducks (28), and chicken (29) fed LEAR oils.…”

Section: Discussionsupporting

confidence: 79%

Cardiopathogenicity of soybean oil and tower rapessed oil triglycerides when fed to male rats

Kramer¹,

Hulan²,

Corner³

et al. 1979

Lipids

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The triglycerides of soybean oil were purified by molecular distillation and those of Tower rapeseed oil by molecular distillation and adsorption chromatography. The original oils and the purified triglycerides were incorporated in semisynthetic diets at 20% by weight and fed for 16 weeks to weanling male Sprague-Dawley rats to compare the nutritional and pathological effects of the oils and their triglyceride fractions on rats. The study was carried out at two independent laboratories. No significant differences were observed between the results of the two establishments. The incidence of myocardial lesions was significantly higher in rats fed Tower rapeseed oil than in those fed soybean oil. Purification of the triglycerides by molecular distillation and adsorption chromatography appeared to have no major effect on the incidence of myocardial lesions. This supports our previous findings that the cardiopathogenicity appeared to have no major effect on the incidence of myocardial lesions. This supports our previous findings that the cardiopathogenicity of the test oils to rats resides in the triglycerides of these oils.

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Section: Discussionsupporting

confidence: 79%

Cardiopathogenicity of soybean oil and tower rapessed oil triglycerides when fed to male rats

Kramer¹,

Hulan²,

Corner³

et al. 1979

Lipids

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“…Many of the early studies showed that supplementation of diets with high erucic acid (HEAR) oils resulted in increased mortality and reductions in feed intake, live weight gain, egg production and egg weight Vles, 1971a, 1973b;Vogtmann et al, 1973;Clement and Renner, 1977). Abdellatif and Vles (1973b) attributed the increased mortality in ducks fed HEAR oil (50% erucic acid) to refusals by the birds to consume the feed, resulting in starvation.…”

Section: Production-related Effects In Poultrymentioning

confidence: 99%

“…The ducks of the low erucic acid group showed no mortality and hydropericardium, but some of them developed vacuolar changes of the heart and skeletal muscles. These lesions had largely disappeared after 3 months (Abdellatif and Vles, ).…”

Section: Assessmentmentioning

confidence: 99%

“…In addition to the pathological effects described above, many studies have been undertaken to examine production‐related effects of feeding full‐fat rape seed, rapeseed meal and rapeseed oil on poultry. Many of the early studies showed that supplementation of diets with high erucic acid (HEAR) oils resulted in increased mortality and reductions in feed intake, live weight gain, egg production and egg weight (Abdellatif and Vles, , ; Vogtmann et al., ; Clement and Renner, ). Abdellatif and Vles () attributed the increased mortality in ducks fed HEAR oil (50% erucic acid) to refusals by the birds to consume the feed, resulting in starvation.…”

Section: Assessmentmentioning

confidence: 99%

“…However, as for other livestock, the possible effects of other dietary constituents or characteristics on feed intake, growth rate and egg production cannot be excluded. At least one study attributed the high oil content of the diet to the reluctance by the birds to consume the feed, resulting in starvation (Abdellatif and Vles, ). Similarly, feed intakes were significantly reduced when diets were supplemented with 15% oil irrespective of the levels of erucic acid in the diet (Vogtmann et al., ).…”

Section: Assessmentmentioning

confidence: 99%

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Erucic acid in feed and food

Knutsen¹,

Alexander²,

Barregård³

et al. 2016

EFS2

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Erucic acid is the trivial name of the fatty acid cis-13-docosenoic acid and occurs at high concentrations mainly in the seeds of species of the Brassicaceae (e.g. rape seed or mustard seed). The European Commission requested EFSA to deliver a scientific opinion on the risks for animal and human health related to the presence of erucic acid in feed and food. For most humans, the main contributor to dietary exposure to erucic acid was the food group 'Fine bakery wares'. In 'Infants', 'Food for infants and small children' was the main contributor to exposure. The heart is the principal target organ for toxic effects after exposure. Myocardial lipidosis was identified as the critical effect for chronic exposure to erucic acid. This effect is reversible and transient during prolonged exposure. A tolerable daily intake (TDI) of 7 mg/kg body weight (bw) per day for erucic acid was established, based on a no observed adverse effect level of 0.7 g/kg bw per day for lipidosis in young rats and newborn piglets. Mean chronic exposure of the different groups of the population did not exceed the TDI. The two highest 95th percentile dietary exposure levels were observed for infants (ranging from 1.7 to 7.4 mg/kg bw per day, minimum lower bound (LB) -maximum upper bound (UB)) and other children (ranging from 2.1 to 9.5 mg/kg bw per day, minimum LB -maximum UB), the last max UB estimate being above the TDI. This may indicate a risk for young individuals with high erucic acid exposure. In pigs, levels of erucic acid are unlikely to represent a health concern. However, for poultry, the small margin between the lowest observed adverse effect level (LOAEL) and the estimated exposure may indicate a health risk where maximum inclusion rates are applied. Due to the absence of adequate data, the risk for ruminants, horses, fish and rabbits could not be assessed.

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Nutritional Status of Low‐Erucic‐Acid Rapeseed Oils

Vles

Bijster

Kleinekoort

et al. 1976

Fette, Seifen, Anstrichm.

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Reflned rapeseed oils with a high and a low-ehcic-acid content were fed to male Wistar rats for six months. Histomorphometric studies of the rhanges in predetermined heart sections indicated a significantly higher incidence and a greater severity of myocardial lesions in rats fed high-erucic-acid (regular) rapeseed oil than in rats fed either low-erucic-acid rapeseed oil or sunfloworseed oil. After administration of various amounts of Primor oil, a French rapeseed oil containing 0.3 % erucic acid, the observed minor changes were indistinguishable in nature, incidence and severity from those observed in control animals.Lecture at the Meeting of the German Society for Fat Research, Hamburg, 6th October 1975.Rogers (Ottawa) for kindly providing the low-erucic-acid rapeseed oils.

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Pathological Effects of Dietary Rapeseed Oils with High or Low Erucic Acid Content in Ducklings

Cited by 11 publications

References 3 publications

Cardiopathogenicity of soybean oil and tower rapessed oil triglycerides when fed to male rats

Cardiopathogenicity of soybean oil and tower rapessed oil triglycerides when fed to male rats

Erucic acid in feed and food

Nutritional Status of Low‐Erucic‐Acid Rapeseed Oils

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