Pathological Evaluation of Canine Hepatic Cirrhosis and Necro-inflammatory Activity

Abstract

Background: Hepatic fibrosis is a common pathological result of chronic liver diseases, which is a dynamic process of liver decomposition mediated by cellular mediators in response to injury.Objective: The present study aims to evaluate the histopathological features of dog-liver fibrosis and / or cirrhosis.Materials and Methods: 40 liver samples were collected; 12 liver fibrosis suspected animals were performed the histopathology to determine the main features of canine liver fibrosis. Results:The histopathology revealed chronic hepatitis with liver islands separated by strips of fibroblasts and collagen, moderate numbers of macrophages, lymphocytes and plasma cells. Also in fibrosis between chronic hepatitis/cirrhosis had a wide range of severity and inflammation was observed primarily around fibrous tissue or was surrounded by fibrous tissue but extended to the liver parenchyma. The histochemical study revealed to a deposition of collagen fibers in the portal, subscapular and interlobular regions. Conclusion:The histopathology revealed a range of lesions vary from mild hepatic degenerative changes to severe fibrotic features associated with canine hepatic fibrosis and early cirrhosis.