Pathological features of 78 metastatic or multicentric neoplasms involving the central nervous system in dogs

Heck, Lilian Cardoso; Cony, Fernanda Genro; Bianchi, Matheus Viezzer; Driemeier, David; Sonne, Luciana; Pavarini, Saulo Petinatti

doi:10.1590/1678-5150-pvb-5925

Cited by 7 publications

(7 citation statements)

References 24 publications

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“…Mammary gland carcinoma is the most common neoplasm among bitches, 20 and in Brazil, it is the main cause of death in bitches with neoplasms. In addition, it has been described as the main metastatic neoplasm involving the central nervous system of dogs 39 similar to the observation of the present study. Up to 17.2% of bitches in the present study had eye involvement from a systemic metastatic disease, with a multifocal, obliterating distribution within blood vessels of the uveal tract, and mainly with a mild predominance of involvement of the anterior uvea.…”

Section: Discussionsupporting

confidence: 91%

Ophthalmopathologic characterization of multicentric or metastatic neoplasms with an extraocular origin in dogs and cats

Bandinelli

Bianchi

Wronski

et al. 2020

Veterinary Ophthalmology

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Objective To characterize the frequency and distribution of secondary ocular neoplasms in dogs and cats identified during necropsy. Methods A retrospective analysis of necropsy records of dogs and cats was conducted, and cases with metastatic/multicentric neoplasms with an extraocular origin, involving the eyes, were selected. Results From January 2015 to January 2019, we identified a total of 233 dogs and 100 cats with metastatic disease. Of these, 11.6% (27/233) of the dogs and 13% (13/100) of the cats had ocular metastases. Lymphoma was the most common multicentric neoplasm involving the eyes of both species. In dogs, these neoplasms occurred bilaterally, predominantly in the anterior uvea, and were diffuse large B‐cell, T‐lymphoblastic, peripheral T‐cell not otherwise specified, and lymphocytic B‐cell lymphomas. In cats, feline leukemia virus (FeLV)‐associated T‐cell lymphoma was the most common. Mammary carcinoma was the second most common ocular metastatic neoplasm in bitches, with a predominantly unilateral involvement of the uveal tract. In cats, following lymphoma, pulmonary and squamous cell carcinomas were the most common multicentric/metastatic neoplasms of the eyes. Individual cases of cholangiocarcinoma, hemangiosarcoma, and chemodectoma in dogs, as well as mammary gland cribriform carcinoma, salivary gland carcinoma, and histiocytic sarcoma in cats were detected. Conclusions The eyes of dogs were mostly affected by lymphoma or mammary gland carcinoma, while those of cats mostly had lymphoma, pulmonary carcinoma, or squamous cell carcinoma as the main metastatic/multicentric neoplasm. To the best of our knowledge, this is the first study to identify intraocular metastatic cholangiocarcinoma and chemodectoma in dogs, aside from identifying salivary gland carcinoma in cats.

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Section: Discussionsupporting

confidence: 91%

Ophthalmopathologic characterization of multicentric or metastatic neoplasms with an extraocular origin in dogs and cats

Bandinelli

Bianchi

Wronski

et al. 2020

Veterinary Ophthalmology

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“…96 Multifocal disease involving metastatic lesions in the CNS is particularly common in the dog, though is documented in other species. 40,47,52,104,106,112 Hemangiosarcoma is the most frequent cause of metastatic CNS neoplasia in the dog, in one review accounting for 51/177 secondary canine brain tumors, most commonly affecting the cerebrum and resulting in disturbances of mentation. 98 There are two purported cases of primary CNS hemangiosarcoma in the veterinary literature: in the cerebrum of a 6-week-old dog 30 and in the meninges overlying the left olfactory bulb in a juvenile pig.…”

Section: Hemangiosarcomamentioning

confidence: 99%

A Review of Proliferative Vascular Disorders of the Central Nervous System of Animals

et al. 2020

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In disease, blood vessel proliferation has many salient roles including in inflammation, when granulation tissue fills superficial defects, or in the recanalization of an occluded blood vessel. Sometimes angiogenesis goes awry—granulation can be exuberant, and plexiform proliferation of vascular components can contribute to pulmonary hypertension. This review focuses on the diverse manifestations of pathologic vascular overgrowth that occur in the brain, spinal cord, and meninges of animals from birth until old age. Entities discussed include systemic reactive angioendotheliomatosis in which glomeruloid vascular proliferations are encountered in various organs including the central nervous system (CNS). The triad of CNS vascular malformations, hamartomas, and benign vascular proliferations are an especially fraught category in which terminology overlap and the microscopic similarity of various disorders makes diagnostic classification incredibly challenging. Pathologists commonly take refuge in “CNS vascular hamartoma” despite the lack of any unique histopathologic features and we recommend that this diagnostic category be abandoned. Malformative lesions that are often confusing and have similar features; the conditions include arteriovenous malformation, cavernous angioma, venous angioma, and capillary telangiectases. Meningioangiomatosis, a benign meningovascular proliferation with dual components, is a unique entity seen most commonly in young dogs. Last, accepted neoplastic conditions range from lower-grade locally acquired growths like hemangioblastoma (a tumor of mysterious interstitial stromal cells encountered in the setting of abundant capillary vasculature proliferation), the rare hemangioendothelioma, and the highly malignant and invariably multifocal metastatic hemangiosarcoma. Additionally, this review draws on the comparative medical literature for further insights into this problematic topic in pathology.

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“…Em ambas as espécies, as neoplasias secundárias foram as de maior ocorrência, representando 70,6% dos casos em caninos e 83,3% nos felinos corroborando com Heck et al (2018) porém diferindo de outros estudos (Troxel et al, 2003;Santos et al, 2012;Spitzbarth et al, 2017;Chaves et al, 2018a;Kishimoto et al, 2020). Assim como observado por Heck et al (2018) a neoplasia secundária de maior ocorrência foi o carcinoma mamário. O principal mecanismo de disseminação dos neoplasmas, observado nesse estudo, foi a metástase, sendo apenas um caso devido a tumor infiltrativo.…”

Section: Discussionunclassified

Neoplasias do sistema nervoso central de caninos e felinos: estudo de 20 anos

Alberti

Zamboni

Venancio

et al. 2021

RSD

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O objetivo desse estudo foi avaliar os aspectos epidemiológicos e patológicos de neoplasias neurológicas em caninos e felinos encaminhados ao Laboratório Regional de Diagnóstico da Faculdade de Veterinária da Universidade Federal de Pelotas (LRD/FV/UFPel) em um período de 20 anos. Foram revisados os protocolos de necropsia de caninos e felinos encaminhados ao LRD/FV/UFPel de janeiro de 2000 a dezembro de 2020, sendo selecionados os casos com diagnóstico de neoplasia neurológica primária e secundária. Destes foram analisadas as informações referentes à idade, sexo, raça, sinais clínicos, achados macroscópicos e histopatológicos. No período estudado foram diagnosticados 35 casos de neoplasias no sistema nervoso central de caninos e seis em felinos. Em ambas as espécies, as neoplasias se mostraram mais frequentes nas fêmeas, animais sem raça definida e com mais de cinco anos de idade, sendo os tumores secundários os mais prevalentes. A região neuroanatômica mais acometida nos caninos foi a tálamo-cortical e nos felinos a medula espinhal. Nos cães o sinal clínico neurológico mais frequente foi convulsão e nos gatos não houve maior ocorrência de nenhum sinal clínico. A ausência de sinais neurológicos foi observada em 37,5% dos caninos e em 50% dos felinos. As principais neoplasias relacionadas a causa de morte de cães e gatos, neste estudo, foram as secundárias, sendo a metástase de carcinoma de mama o principal diagnóstico, podendo ainda, em muitos casos não serem observados sinais clínicos neurológicos.

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Pathological features of 78 metastatic or multicentric neoplasms involving the central nervous system in dogs

Cited by 7 publications

References 24 publications

Ophthalmopathologic characterization of multicentric or metastatic neoplasms with an extraocular origin in dogs and cats

Ophthalmopathologic characterization of multicentric or metastatic neoplasms with an extraocular origin in dogs and cats

A Review of Proliferative Vascular Disorders of the Central Nervous System of Animals

Neoplasias do sistema nervoso central de caninos e felinos: estudo de 20 anos

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