Pathological features of prostate cancer detected on initial and repeat prostate biopsy: Results of the prospective European prostate cancer detection study

Djavan, Bob; Mazal, Peter R.; Zlotta, Alexandre R.; Wammack, R.; Ravery, Vincent; Remzi, Mesut; Susani, Martin; Borkowski, Andrzej; Hruby, Stefan; Boccon-Gibod, L; Schulman, Claude; Marberger, Michael

doi:10.1002/pros.1053

Cited by 86 publications

(33 citation statements)

References 30 publications

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“…Eskew's [9] ''5-region'' biopsy technique, which focuses on the far lateral and midregions of the gland, in addition to the standard sextant technique, is reported to have an impressive diagnostic yield. Cancers missed on initial biopsy and subsequently detected on repeat biopsy are often located in a more apicodorsal location, so repeat biopsies could be preferentially directed to include this spared area [10]. Alternatively, emerging evidence claims that the use of transurethral resection of the prostate combined with a set of needle biopsies of the lateral portion of the gland has a high diagnostic yield after repeated negative biopsies in those with increasing PSA levels [11].…”

Section: Discussionmentioning

confidence: 98%

A review of repeat prostate biopsies and the influence of technique on cancer detection: our experience

et al. 2009

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Section: Discussionmentioning

confidence: 98%

A review of repeat prostate biopsies and the influence of technique on cancer detection: our experience

et al. 2009

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“…The second round of biopsies in this large study detected an additional 10% of cancers. The chance of finding PCa after the second biopsy decreases dramatically [3]. There is evidence that saturation biopsies are helpful to detect PCa in patients where multiple sets of biopsies have failed.…”

Section: Discussionmentioning

confidence: 99%

“…Most patients with a negative first biopsy undergo at least one rebiopsy. After two sets of ten or more negative core biopsies it seems that the risk of missing/overlooking cancer in patients with stable PSA levels [3] is acceptably low. Particularly in those patients with rising PSA levels, multiple biopsies are often performed without prostate cancer (PCa) being detected.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Transrectal Prostate Biopsy Results with Histology of Transurethral Resection of the Prostate in Men Undergoing High-Intensity Focused Ultrasound

Rogenhofer

Walter²,

Hartmann

et al. 2013

Urol Int

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Introduction: The aim of our study was to evaluate the significance of transurethral resection of the prostate (TURP) to detect prostate cancer (PCa). A comparison was performed of the TURP specimens of patients undergoing high-intensity focused ultrasound (HIFU) with the core biopsies. Materials and Methods: TURP before undergoing HIFU therapy was performed in 106 patients without neoadjuvant treatment. The resected tissue was subjected to histopathological evaluation and compared to the histological results of transrectal prostate biopsy. Results: Cancer was detected in the resected tissue of 69 patients (65%). A positive correlation of the amount of resected tissue and detection of PCa could be demonstrated in a multivariate analysis. Conclusions: With a rate of 65% PCa detected by TURP, our data provide evidence that TURP might be suitable to detect PCa in a small group of selected patients with continuously rising PSA levels and several negative biopsies. On the other hand, these data underline/reinforce the necessity to treat the whole gland using modern treatment modalities such as HIFU and cryotherapy.

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“…De kans op een fout-negatieve uitslag bij een eerste biopt is vrij hoog, namelijk 20-25 %. Bij een tweede biopt ligt dit percentage rond de 10-15 [5][6][7]. Het is dan ook wenselijk om een nieuwe diagnostische test te ontwikkelen, die beter kan discrimineren tussen het gezonde individu en de patiënt met prostaatkanker.…”

Section: Introductieunclassified

Opsporen van prostaatkanker in uitademingslucht met behulp van een draagbare elektronische neus

Waltman

Roermund

2018

Tijdschr Urol

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SamenvattingDe laatste jaren zijn verschillende non-invasieve technieken onderzocht om opsporing van prostaatkanker te verbeteren. Dit onderzoek gaat over de analyse van uitademingslucht door een geavanceerde, gebruiksvriendelijke en draagbare elektronische neus, de Aeonose Trefwoorden prostaatkanker · uitademingslucht · elektronische neus · volatile organic compound (VOC)Detecting prostate cancer by analyzing exhaled-breath using a portable electronic nose (Aeonose TM ) Abstract In the last decade, several non-invasive methods have been researched in order to improve detection of prostate cancer (PCa). This study investigated the possibility of detecting PCa based on exhaled-breath analysis using an advanced, easy-to-use, portable electronic nose ('Aeonose TM '). Exhaled-breath was probed from 85 patients. Within this population, 32 were diagnosed with primary PCa, and 53 patients were used as controls: 30 having negative biopsies, 23 with benign prostate hyperplasia. In order to differentiate between groups, an artificial neural network was trained. This trained model showed an area under the curve of 0.79 with a sensitivity and specificity of 0.84 (95% CI = 0.66-0.94) and 0.70 (95% CI = 0.55-0.81) respectively, when comparing primary PCa and controls. Negative predictive value found was 0.88. In conclusion, these promising results imply Aeonose™ exhaled-breath analysis can be used to detect PCa.Keywords prostate cancer · exhaled-breathe · electronic nose · volatile organic compounds (VOCs) IntroductieAl sinds de Griekse oudheid is bekend dat uitademingslucht informatie bevat over iemands gezondheidstoestand. Uit onderzoek is gebleken dat honden een zeer goed ontwikkeld reukorgaan hebben en concentraties van 0,001 deeltjes

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Pathological features of prostate cancer detected on initial and repeat prostate biopsy: Results of the prospective European prostate cancer detection study

Cited by 86 publications

References 30 publications

A review of repeat prostate biopsies and the influence of technique on cancer detection: our experience

A review of repeat prostate biopsies and the influence of technique on cancer detection: our experience

Comparison of Transrectal Prostate Biopsy Results with Histology of Transurethral Resection of the Prostate in Men Undergoing High-Intensity Focused Ultrasound

Opsporen van prostaatkanker in uitademingslucht met behulp van een draagbare elektronische neus

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