2001
DOI: 10.1002/pros.1053.abs
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Pathological features of prostate cancer detected on initial and repeat prostate biopsy: Results of the prospective European prostate cancer detection study

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Cited by 20 publications
(27 citation statements)
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“…Moreover, final pathological examinations demonstrated that tumor volumes in patients diagnosed on repeat biopsy were significantly smaller than those in patients diagnosed on initial biopsy, although there were no significant differences in the distributions of pathological T stage or Gleason score, or in the incidences of lymphatic invasion, vascular invasion, and perineural invasion between the two groups. These findings are consistent with the study done by Djavan et al, 13 who did not observe any differences in stage or Gleason score of radical prostatectomy specimens between patients diagnosed on the first biopsy and those diagnosed on the second set of biopsies. However, Steiner et al 15 demonstrated a significant decrease in pathological stage and Gleason score in prostate cancer detected at rebiopsy compared with those detected at the initial biopsy, despite the absence of any further decrease from the second to fifth set of biopsies.…”
Section: Discussionsupporting
confidence: 95%
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“…Moreover, final pathological examinations demonstrated that tumor volumes in patients diagnosed on repeat biopsy were significantly smaller than those in patients diagnosed on initial biopsy, although there were no significant differences in the distributions of pathological T stage or Gleason score, or in the incidences of lymphatic invasion, vascular invasion, and perineural invasion between the two groups. These findings are consistent with the study done by Djavan et al, 13 who did not observe any differences in stage or Gleason score of radical prostatectomy specimens between patients diagnosed on the first biopsy and those diagnosed on the second set of biopsies. However, Steiner et al 15 demonstrated a significant decrease in pathological stage and Gleason score in prostate cancer detected at rebiopsy compared with those detected at the initial biopsy, despite the absence of any further decrease from the second to fifth set of biopsies.…”
Section: Discussionsupporting
confidence: 95%
“…Furthermore, to our knowledge, there have been few studies analyzing the pathological data of radical prostatectomy specimens obtained from patients diagnosed after an initial negative biopsy. [13][14][15][16] Considering these findings, more data are necessary to characterize the clinicopathological features of prostate cancer detected after false-negative biopsy findings.…”
Section: Discussionmentioning
confidence: 98%
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“…Published reports suggest that systematic TRUS-guided biopsy detects PCa in 15.2% in men with PSA serum levels \4 ng/mL (PSA subgroup 1), in 22% in men with PSA serum levels 4-10 ng/mL at first biopsy session (PSA subgroup 2) and in 46% in men with PSA serum levels [10 ng/mL (PSA subgroup 3) [11][12][13]. Our study patients were cancer positive in 47.6% in the PSA subgroup 1, in 58.8% in the PSA subgroup 2 and in 70.4% in the PSA subgroup 3.…”
Section: Discussionmentioning
confidence: 98%