Pathological Fractures in Primary Non-Hodgkin’s Lymphoma of the Bone: A Case Series with Review of the Literature

Siddiqui, Yasir Salam

doi:10.7860/jcdr/2013/3948.2809

Cited by 10 publications

(9 citation statements)

References 7 publications

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“…Local pain and swelling are usually the most common presenting complaints [15] but multiple discharging sinuses has rarely been seen as a feature as was seen in one of our cases which was misleading towards an infectious etiology. Radiologically, there exists a wide spectrum of findings ranging from a normal appearing bone to an extensive, destructive or infiltrative lesion.…”

Section: Discussionmentioning

confidence: 50%

Primary bone lymphomas—Clinical cases and review of literature

Jain

Alam

Maheshwari

et al. 2013

Journal of Bone Oncology

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Primary bone lymphoma (PBL) is an uncommon clinical entity and a rare presentation of non-Hodgkin's lymphoma. PBL accounts for less than 5% of malignant bone tumors, 4–5% of extra nodal lymphoma and less than 1% of all non-Hodgkin's lymphoma. Diffuse large-B-cell lymphoma (DLBCL) accounts for the majority of cases of PBL. The incidence of PBL is so rare that many of its aspects remain unknown. A number of studies have been reported from western countries but only a few reports are available from Asia. Out of 20,000 bone lesions received in our department over 5 years, only 5 cases were primary bone lymphoma; all of which were DLBCL. We report our experience on PBLs with main emphasis on two unusual presentations of this rare tumor.

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Section: Discussionmentioning

confidence: 50%

Primary bone lymphomas—Clinical cases and review of literature

Jain

Alam

Maheshwari

et al. 2013

Journal of Bone Oncology

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“…The diagnosis is established by biopsy. 4 The histological features of primary nonHodgkin's lymphoma of the bone are identical to those of the conventional, non-osseous forms of non-Hodgkin's lymphoma. The hallmark attribute of the lesion is a replacement of the normal marrow constituents by neoplastic lymphoid tissue; the most common subtype is diffuse large B-cell lymphoma.…”

Section: Discussionmentioning

confidence: 59%

Primary intraosseous lymphoma at right femur

et al. 2015

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PATHOLOGY Case ReportPrimary intraosseous lymphoma at right femur Lymphomas, the malignant neoplasms of the reticuloendothelial and lymphatic system, are classiied based on characterisitic morphological pattern, immunophenotypic pattern and sometimes distinctive chromosomal aberrations. Most of the intraosseous lymphomas should be metastatic, and primary intraosseous lymphoma is a rare type of lymphoma, which accounts for only about 5% extranodal lymphoma. It accounts for approximately 3% of all primary bone malignancies.We report a case of 54 years lady presented with pain over right thigh since 3 to 4 months which suddenly increased. The clinico-radiological differential diagnosis was ibrous dysplasia, plasmacytoma or metastasis. The histological indings and immunohistochemistry being positive for CD20 and BCL2 negative are those of Lymphoma-Diffuse large B cell type. Radiotherapy and/or chemotherapy is the preferred modality of management.

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“…13) and radiotherapy. 24,31 Surgery is only indicated in case of complications, such as for instance in the case of pathologic fractures 41 or spinal cord compression with neurologic deficits. The most common chemotherapy regimen for aggressive non-Hodgkin's lymphoma is cyclophosphamide, hydroxydaunorubicin (doxorubicin), oncovin (vincristine), and prednisone/prednisolone (CHOP).…”

Section: Therapy and Treatment Monitoringmentioning

confidence: 99%

Ewing's Sarcoma and Primary Osseous Lymphoma: Spectrum of Imaging Appearances

Weber

Papakonstantinou

Nikodinovska

et al. 2019

Semin Musculoskelet Radiol

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Ewing's sarcoma (ES) is a rare, highly malignant anaplastic stem cell tumor. Histologically, the tumor consists of uniform densely packed small monomorphic cells with round nuclei. The typical appearance at hematoxylin and eosin (H&E) staining is small blue round cells without any matrix formation. On conventional radiography, ES typically presents as a permeative lesion in the diaphysis of a long bone in a child. A large soft tissue component is another characteristic feature, best depicted by magnetic resonance imaging.Primary osseous lymphomas are most commonly highly malignant B-cell lymphomas. At H&E histologic staining, the tumor stroma consists of diffuse round-cell infiltrates that resembles the appearance of ES. Although there is no typical imaging appearance of an osseous lymphoma, it should be considered in an adult presenting with a Lodwick grade II or III lesion in the metaphysis or diaphysis of a large long bone, the pelvis, or the vertebral column. Histologic confirmation is mandatory.

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Pathological Fractures in Primary Non-Hodgkin’s Lymphoma of the Bone: A Case Series with Review of the Literature

Cited by 10 publications

References 7 publications

Primary bone lymphomas—Clinical cases and review of literature

Primary bone lymphomas—Clinical cases and review of literature

Primary intraosseous lymphoma at right femur

Ewing's Sarcoma and Primary Osseous Lymphoma: Spectrum of Imaging Appearances

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