Pathological, Immunohistochemical and Bacteriological Findings in Kidneys of Cattle with Contagious Bovine Pleuropneumonia (CBPP)

Grieco, Valeria; Boldini, M.; Luini, M.; Finazzi, M.; Mandelli, G.; Scanziani, Eugenio

doi:10.1053/jcpa.2000.0433

Cited by 9 publications

(16 citation statements)

References 14 publications

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“…2). The large number of transport proteins in MmymySC, compared with the other species M. pulmonis, may result in MmymySC being better equipped to persist different tissue environments, reflecting its capability to form more or less systemic infections (Gourlay 1964;Masiga et al 1972;Scanziani et al 1997;Stradaioli et al 1999;Grieco et al 2001). The high number of MmymySC genes within "other categories" is due to the large amount of transposase genes located within the IS elements.…”

Section: General Genome Featuresmentioning

confidence: 99%

The Genome Sequence of Mycoplasma mycoides subsp. mycoides SC Type Strain PG1^T, the Causative Agent of Contagious Bovine Pleuropneumonia (CBPP)

Westberg¹,

Persson²,

Holmberg³

et al. 2004

Genome Res.

170

162

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Mycoplasma mycoides subsp. mycoidesSC (MmymySC)is the etiological agent of contagious bovine pleuropneumonia (CBPP), a highly contagious respiratory disease in cattle. The genome of Mmymy SC type strain PG1T has been sequenced to map all the genes and to facilitate further studies regarding the cell function of the organism and CBPP. The genome is characterized by a single circular chromosome of 1,211,703 bp with the lowest G+C content (24 mole%)and the highest density of insertion sequences (13% of the genome size)of all sequenced bacterial genomes. The genome contains 985 putative genes, of which 72 are part of insertion sequences and encode transposases. Anomalies in the GC-skew pattern and the presence of large repetitive sequences indicate a high genomic plasticity. A variety of potential virulence factors was identified, including genes encoding putative variable surface proteins and enzymes and transport proteins responsible for the production of hydrogen peroxide and the capsule, which is believed to have toxic effects on the animal.

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Section: General Genome Featuresmentioning

confidence: 99%

The Genome Sequence of Mycoplasma mycoides subsp. mycoides SC Type Strain PG1^T, the Causative Agent of Contagious Bovine Pleuropneumonia (CBPP)

Westberg¹,

Persson²,

Holmberg³

et al. 2004

Genome Res.

170

162

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“…12 In one study of 3,129 cattle, single and multiple infarcts were observed in 88 of 716 animals (12.2%) at necropsy. 13 Chronic lesions were characterized by "multifocal to coalescing white areas" with moderate fibrosis, varying from 1 to 5 cm in diameter, and, in addition to infarctions, multiple white foci from chronic interstitial nephritis were also found. They were 1 to 4 mm in diameter, identified in 301 of 3,124 animals (9.6%) with and without concurrent CBPP pulmonary lesions.…”

Section: Resultsmentioning

confidence: 99%

Comparison of LionHeart LVAD-Implanted Calves Based on Renal Infarctions

Connell¹,

Pae²,

Rosenberg³

2007

ASAIO Journal

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Calves implanted with the LionHeart left ventricular assist device during the Food and Drug Administration Investigational Device Exemption (IDE) trial had fewer renal infarctions than calves implanted after this trial (post-IDE). Since a decrease in renal infarctions indicates a favorable outcome, we compared nine IDE with 16 post-IDE implantations. Renal infarct severity was graded (0 to 4) on the basis of necropsy reports, histopathology reports, and photographs. Implants were compared for duration of support, anticoagulation, device flow, percent fill, device rate, free plasma hemoglobin, fibrinogen, platelet count, nonsteroidal anti-inflammatory drug use, inlet cannula shape, and outlet graft-to-graft anastomosis technique. IDE calves had lower renal pathology scores (1.8 vs. 2.8, p = 0.03), mean device percent fill (88.5% vs. 94.0%, p = 1 x 10), and median free plasma hemoglobin (2.6 vs. 4.4 mg/dL, p = 0.01). IDE animals also had a higher mean device rate (108 vs. 98 bpm, p = 0.04), received low-molecular-weight dextran in the early postoperative period, began oral warfarin earlier, had straighter inlet cannulae, and had factory-sewn outlet graft-to-graft anastomoses. Duration of support did not predict severity of renal infarction, and there were no differences in device flow, international normalized ratio, platelet count, or nonsteroidal anti-inflammatory drug use. These results could assist future implantations.

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“…The presence of lesions in the kidneys is typically observed in a proportion of cattle infected with CBPP and has been reported in both field ( 30 ) and experimental ( 31 ) infections. Kidney lesions were also observed in 88 (12.2%) of 716 cattle killed after an outbreak of CBPP in 61 herds between 1990 and 1991 in Lombardy, Italy ( 32 ). Although no attempt was made to isolate live M. mycoides subsp.…”

Section: Discussionmentioning

confidence: 99%

“… mycoides from kidneys in the present study, previous isolation of viable M. mycoides subsp. mycoides from kidneys has been achieved ( 31 – 33 ). In two of these studies, the presence of viable M. mycoides subsp.…”

Section: Discussionmentioning

confidence: 99%

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Vaccination of Cattle with the N Terminus of LppQ of Mycoplasma mycoides subsp. mycoides Results in Type III Immune Complex Disease upon Experimental Infection

et al. 2015

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Contagious bovine pleuropneumonia (CBPP) is a serious respiratory disease of cattle caused by Mycoplasma mycoides subsp. mycoides. Current vaccines against CBPP induce short-lived immunity and can cause severe postvaccine reactions. Previous studies have identified the N terminus of the transmembrane lipoprotein Q (LppQ-N′) of M. mycoides subsp. mycoides as the major antigen and a possible virulence factor. We therefore immunized cattle with purified recombinant LppQ-N′ formulated in Freund's adjuvant and challenged them with M. mycoides subsp. mycoides. Vaccinated animals showed a strong seroconversion to LppQ, but they exhibited significantly enhanced postchallenge glomerulonephritis compared to the placebo group (P = 0.021). Glomerulonephritis was characterized by features that suggested the development of antigen-antibody immune complexes. Clinical signs and gross pathological scores did not significantly differ between vaccinated and placebo groups. These findings reveal for the first time the pathogenesis of enhanced disease as a result of antibodies against LppQ during challenge and also argue against inclusion of LppQ-N′ in a future subunit vaccine for CBPP.

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Pathological, Immunohistochemical and Bacteriological Findings in Kidneys of Cattle with Contagious Bovine Pleuropneumonia (CBPP)

Cited by 9 publications

References 14 publications

The Genome Sequence of Mycoplasma mycoides subsp. mycoides SC Type Strain PG1^T, the Causative Agent of Contagious Bovine Pleuropneumonia (CBPP)

The Genome Sequence of Mycoplasma mycoides subsp. mycoides SC Type Strain PG1^T, the Causative Agent of Contagious Bovine Pleuropneumonia (CBPP)

Comparison of LionHeart LVAD-Implanted Calves Based on Renal Infarctions

Vaccination of Cattle with the N Terminus of LppQ of Mycoplasma mycoides subsp. mycoides Results in Type III Immune Complex Disease upon Experimental Infection

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Pathological, Immunohistochemical and Bacteriological Findings in Kidneys of Cattle with Contagious Bovine Pleuropneumonia (CBPP)

Cited by 9 publications

References 14 publications

The Genome Sequence of Mycoplasma mycoides subsp. mycoides SC Type Strain PG1T, the Causative Agent of Contagious Bovine Pleuropneumonia (CBPP)

The Genome Sequence of Mycoplasma mycoides subsp. mycoides SC Type Strain PG1T, the Causative Agent of Contagious Bovine Pleuropneumonia (CBPP)

Comparison of LionHeart LVAD-Implanted Calves Based on Renal Infarctions

Vaccination of Cattle with the N Terminus of LppQ of Mycoplasma mycoides subsp. mycoides Results in Type III Immune Complex Disease upon Experimental Infection

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The Genome Sequence of Mycoplasma mycoides subsp. mycoides SC Type Strain PG1^T, the Causative Agent of Contagious Bovine Pleuropneumonia (CBPP)

The Genome Sequence of Mycoplasma mycoides subsp. mycoides SC Type Strain PG1^T, the Causative Agent of Contagious Bovine Pleuropneumonia (CBPP)