2024
DOI: 10.3390/ijms251810187
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Pathological Involvement of Protein Phase Separation and Aggregation in Neurodegenerative Diseases

Yinuo Wu,
Biao Ma,
Chang Liu
et al.

Abstract: Neurodegenerative diseases are the leading cause of human disability and immensely reduce patients’ life span and quality. The diseases are characterized by the functional loss of neuronal cells and share several common pathogenic mechanisms involving the malfunction, structural distortion, or aggregation of multiple key regulatory proteins. Cellular phase separation is the formation of biomolecular condensates that regulate numerous biological processes, including neuronal development and synaptic signaling t… Show more

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