Pathological Markers of Alzheimer’s Disease and Related Dementia in the Rhesus Macaque Amygdala
Jeremy L. Thomas,
Benjamin I. Nilaver,
Alejandro Lomniczi
et al.
Abstract:Rhesus macaques develop amyloid-β (Aβ) plaques during old age, but it is unclear how extensively they express other pathological hallmarks of dementia. Here we used immunohistochemistry to examine expression of phosphorylated tau (pTau) protein and cytoplasmic inclusions of TAR DNA binding protein 43 kDa (TDP-43) within the amygdala of young and old males, and also in old surgically-menopausal females that were maintained on regular or obesogenic diets. Only one animal, a 23-year-old female, showed pTau expres… Show more
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