Pathological prognostic factors in breast cancer. II. Histological type. Relationship with survival in a large study with long‐term follow‐up

Abstract

Pathological prognostic factors in breast cancer. 11. Histological type. Relationship with survival in a large study with long-term follow-upThe histological tumour type determined by current criteria has been investigated in a consecutive series of 162 1 women with primary operable breast carcinoma, presenting between 1973 and 1987. All women underwent definitive surgery with node biopsy and none received adjuvant systemic therapy. Special types, tubular, invasive cribriform and mucinous, with a very favourable prognosis can be identified. A common type of tumour recognized by our group and designated tubular mixed carcinoma is shown to be prognostically distinct from carcinomas of no special type: it has a characteristic histological appearance and is the third most common type in this series. Analysis of subtypes of lobular carcinoma confirms differing prognoses. The classical, iubulo-lobular and lobular mixed types are associated with a better prognosis than carcinomas of no special type: this is not so for the solid variant. Tubulolobular carcinoma in particular has an extremely good prognosis similar to tumours included in the 'special type' category above. Neither medullary carcinoma nor atypical medullary carcinoma are found to carry a survival advantage over carcinomas of no special type. The results confirm that histological typing of human breast carcinoma can provide useful prognostic information.

The biological and clinical characteristics of breast carcinoma with mixed ductal and lobular morphology

“…Patient's clinical history and tumour characteristics including patients' age, menopausal status, bilaterality, family history, type and number of primary operation and axillary lymph node surgery, primary tumour size, histologic tumour type [6], histologic grade [33], lymph node (LN) status, vascular invasion (VI), NPI and oestrogen receptor (ER) status were obtained from the database. Survival data including survival time, disease free interval, and development of distant metastasis (DM), local and regional recurrence was maintained on a prospective basis.…”

“…Invasive ductal (IDC) and invasive lobular (ILC) breast carcinomas are the most common types of breast cancer, accounting for 72-80% and 5-15% of invasive breast cancer respectively [1][2][3][4], while tumours with mixed histologic types (mixed ductal and lobular) are less common, accounting for 3-5% [5][6][7]. Several studies have reported that whereas the incidence of IDC has remained stable, the incidence of ILC and mixed ductal and lobular tumours are increasing particularly among postmenopausal women [5,8].…”

“…In addition, it has been reported that ILC is less responsive to chemotherapy [3,21], lacks potential benefit of HER2 targeted therapy [16,17], being typically HER2 negative, but is more often HR positive and responsive to adjuvant hormonal therapy (HT) [11,22,23]. Reported prognosis of ILC varies and has been reported to be worse [1,9,[24][25][26][27], no different [17,[28][29][30][31][32], or better [6] than that with IDC.…”

An evaluation of the clinical significance of FOXP3+ infiltrating cells in human breast cancer

“…These include histologic grade [35], histologic tumour type [36], vascular invasion (VI) [37], primary tumour size, and lymph node (LN) stage, and Nottingham prognostic index (NPI) [38] which were routinely assessed and recorded in the database as well as patients' information such as age, family history, and menopausal status. The clinicopathological characteristics of the series are presented in Table 1.…”

The proteins FABP7 and OATP2 are associated with the basal phenotype and patient outcome in human breast cancer

“…All patients had been assessed in a standardised manner for clinical history and tumour characteristics including age, menopause status, tumour type [29], histological grade [30], tumour size, tumour recurrence, presence of distance metastasis, lymph node status, vascular invasion and Nottingham Prognostic Index (NPI) [31]. Data relating to survival was collated in a prospective manner including breast cancer specific survival (BCSS), defined as the interval (in months) from the date of the primary treatment to the time of death due to breast cancer, and disease free interval (DFI), defined as the interval (in months) from the …”