Pathological-radiological correlations in benign lesions excised during a breast screening programme

Spencer, Nicholas; Evans, Andrew; Galea, M.H.; Sibbering, D.M.; Yeoman, L.J.; Pinder, Sarah; Ellis, Ian O.; Elston, C.W.; Blamey, R. W.; Robertson, J.F.R.; Wilson, A.R.M.

doi:10.1016/s0009-9260(05)82874-0

Cited by 30 publications

(17 citation statements)

References 10 publications

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“…Fibroadenoma and fibrocystic disease were the most frequent lesions included in the current and previously published series 31,32,34,52 (Table 6). Previous studies on screening series have demonstrated that greater numbers of 'pure' benign lesions are being excised 31,32 ( Table 5), but the increasing accuracy of preoperative diagnosis after the introduction of needle biopsy probably will lead to a decrease in this number over time.…”

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confidence: 70%

“…Papillary lesions (14 of 83 biopsies) and RS (10 of 83 biopsies) were the most common lesions in this group and accounted for 16.8% and 12% of all benign open biopsies, respectively (Table 4). In other screening series, benign breast lesions at low risk of developing cancer ranged from 8.6% to 34.4% [31][32][33] (Table 5). RS has a well documented association with cancer in many clinical series, 44,45 and it was the most frequent lesion in the category of benign breast lesion at low risk of developing cancer in women who underwent to surgery [31][32][33] (Table 6).…”

Section: Histology 4 Category: Benign Proliferative Lesions With Highmentioning

confidence: 94%

“…In other screening series, benign breast lesions at low risk of developing cancer ranged from 8.6% to 34.4% [31][32][33] (Table 5). RS has a well documented association with cancer in many clinical series, 44,45 and it was the most frequent lesion in the category of benign breast lesion at low risk of developing cancer in women who underwent to surgery [31][32][33] (Table 6). Papillary lesions may show intralesional heterogeneity, and cancer or lesions with a high risk of developing cancer may be detected in open biopsy 22,27 in up to 30% of excised lesions.…”

Section: Histology 4 Category: Benign Proliferative Lesions With Highmentioning

confidence: 94%

“…One patient without mammographic suspicious lesion (BIRADS score, 1) had nonspontaneous nipple discharge. [31][32]34 (Table 5). In the current benign surgical biopsy screening series, 57.8% of lesions were proliferative lesions that were at risk of developing cancer ( Table 4).…”

Section: Histology 4 Category: Benign Proliferative Lesions With Highmentioning

confidence: 99%

“…Only a few studies have analyzed the impact of proliferative breast lesions at risk of developing cancer on the benign open biopsy rate in screening programs. [31][32][33][34] The current report describes the histologic types of benign lesions in open biopsies performed in the Breast Cancer Screening Program of Verona (BCSPV) and defines the proportion of lesions at risk of developing cancer. The performance and impact indicators of BCSPV also were analyzed.…”

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confidence: 99%

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Benign breast lesions at risk of developing cancer—A challenging problem in breast cancer screening programs

Manfrin

Mariotto

Remo

et al. 2009

Cancer

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BACKGROUND:Cytology and core‐needle biopsies are not always sufficient to exclude malignancy in benign breast lesions (BBL) that are at risk of developing cancer, and open biopsy often is mandatory. In screening programs, open biopsies performed for lesions that are at risk of developing malignancy are considered benign. The authors of this report evaluated the impact of the screen‐detected BBL at risk of developing cancer that were counted in the quota of benign breast open biopsies in the Breast Cancer Screening Program of Verona.METHODS:Benign open biopsies were subdivided into 4 groups according to their risk of developing cancer: Histo1, normal histology; Histo2, ‘pure’ BBL (fibroadenoma, fibrocystic disease, mastitis, adenosis); Histo3, BBL with a low risk of developing cancer (radial scar, papilloma, papillomatosis, phyllodes tumor, mucocele‐like lesion); and Histo4, BBL with a high risk of developing cancer (atypical columnar cell hyperplasia, atypical ductal hyperplasia, atypical lobular hyperplasia).RESULTS:Of 510 open biopsies, 83 biopsies were benign, and the ratio of benign to malignant biopsies was 1:5. Histo1 was observed in 4.8% of all benign open biopsies, Histo2 was observed in 37.4%, Histo3 was observed in 31.3%, and Histo4 was observed 26.5%.CONCLUSIONS:BBL at risk of developing cancer may be numerous in screening programs. It is inappropriate to include BBL at risk of developing cancer in the overall benign open biopsy rate. The authors propose separating pure BBL from lesions at higher risk of developing cancer. To date, there is no evidence to support the premise that detecting high‐risk proliferative lesions leads to benefits in terms of reduced mortality; however, these lesions need to be counted separately for future evaluations. Cancer 2009. © 2008 American Cancer Society.

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confidence: 70%

Section: Histology 4 Category: Benign Proliferative Lesions With Highmentioning

confidence: 94%

Section: Histology 4 Category: Benign Proliferative Lesions With Highmentioning

confidence: 94%

Section: Histology 4 Category: Benign Proliferative Lesions With Highmentioning

confidence: 99%

mentioning

confidence: 99%

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Benign breast lesions at risk of developing cancer—A challenging problem in breast cancer screening programs

Manfrin

Mariotto

Remo

et al. 2009

Cancer

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Is there a role for fine-needle aspiration in radial scar/complex sclerosing lesions of the breast?

et al. 1997

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The fine‐needle aspiration cytology (FNA) from 12 mammographically detected, histologically confirmed radial scar/complex sclerosing lesions (RS/CSL) and their corresponding mammography were reviewed. Six aspirates were obtained by palpation, four by ultrasound guidance, and two by stereotactic guidance. Of the eight lesions with sufficient material, five (62.5%) were reported as benign, two (25%) as atypical, and one (12.5%) as suspicious. It is proposed that FNA for RS/CSL should not be performed, and lesions require excision for histologic assessment. Diagn. Cytopathol. 16:537–542, 1997. © 1997 Wiley‐Liss, Inc.

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Breast Imaging

Benito

Herrero

Learning Diagnostic Imaging

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Pathological-radiological correlations in benign lesions excised during a breast screening programme

Cited by 30 publications

References 10 publications

Benign breast lesions at risk of developing cancer—A challenging problem in breast cancer screening programs

Benign breast lesions at risk of developing cancer—A challenging problem in breast cancer screening programs

Is there a role for fine-needle aspiration in radial scar/complex sclerosing lesions of the breast?

Breast Imaging

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