Pathological remodeling of myocardium in spontaneous hypertensive rats with experimental diabetes mellitus: the role of mitochondrial dysfunction

IuM, Kolesnyk; Kolesnyk, M. Y.; Av, Abramov

doi:10.15407/fz60.03.018

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…It aims to develop students' high-grade performing and teaching skills, professional skills, and the need for self-expression and self-development. In this matter, the decisive for us was the opinion of A. Kolesnyk, at the creative level, highly developed skills and mastery are manifested in a specific activity through the awareness of not only the goal but also the ways to achieve it, as well as through the skills used [6]. For future pianists, the creative process is performing and teaching.…”

Section: освіта інноватика практикаmentioning

confidence: 99%

Features of the Formation of Academic Culture of Future Pianists

Chuanjie

2024

OIP

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The essence of the research is to problem-study the formation of the academic culture of future pianists. As an essential factor, the academic environment considers pianists' individual needs in terms of education and is absorbed into professional educational programs. Forming this culture requires understanding the artistic mission and its impact on society and developing critical thinking and communication skills. The article describes the process of forming the academic culture of future pianists, which takes place in the academic environment and considers the individual needs of pianists in academic education. It is emphasized that this process cannot be fully ensured by mastering only artistic disciplines. It requires developing critical thinking and communication skills that contribute to forming value orientations and self-development in this area. The article proposes a model that describes the process of forming the academic culture of future pianists. Theoretical methods such as analysis of scientific sources and modeling are used to idealize this process. The structural elements of the model are described, including the target, theoretical and methodological (including approaches and principles), pedagogical conditions (development of students' critical thinking; encouragement to participate in scientific, educational, and practical informal activities; development of communication skills in professional communication) and content and procedural module (including a description of the unique course). The stages of model implementation that contribute to positive changes in the levels of academic culture of future pianists are considered. The result of the model implementation is positive changes in the formation levels of the components of the academic culture of future pianists.

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Section: освіта інноватика практикаmentioning

confidence: 99%

Features of the Formation of Academic Culture of Future Pianists

Chuanjie

2024

OIP

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Hyperhomocysteinemia in the pathogenesis of cardiovascular and endocrine diseases: translational messages

Kaminsky

Yanchyshyn

Belemets³

et al. 2022

Minerva Biotechnol Biomol Res

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The Effects of Cardiotrophin-1 on Early Synaptic Mitochondrial Dysfunction and Synaptic Pathology in APPswe/PS1dE9 Mice

Wang

Liu

et al. 2017

JAD

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The coexistence of neuronal mitochondrial pathology and synaptic dysfunction is an early pathological feature of Alzheimer's disease (AD). Cardiotrophin-1 (CT-1) has been shown to exhibit impressive neuroprotective effects. Previous studies have shown positive effects of CT-1 on brain glucose metabolism and cognition in APPswe/PS1dE9 transgenic mice; however, little is known about the effects of CT-1 on early synaptic mitochondrial dysfunction and resultant synaptic pathology in the brain. In this study, 4-month-old transgenic mice with brain tissue-specific CT-1 expression were used alone or in combination with APPswe/PS1dE9 transgenic mice to evaluate the effect of CT-1 on synaptic mitochondrial dysfunction and resultant synaptic pathology, and cryptic memory deficits in the APPswe/PS1dE9 transgenic mice. The potential mechanism of action of CT-1 was also examined. Young CT-1×APPswe/PS1dE9 transgenic mice exhibited improvements in long-term learning and memory ability and ameliorations of synaptic mitochondrial/synaptic impairments compared to young APPswe/PS1dE9 transgenic mice. Moreover, CT-1 upregulated the expression of AMPAR and increased AMP-activated protein kinase (AMPK) activity in the hippocampus of APPswe/PS1dE9 transgenic mice. However, AMPK inhibition through shRNA knockdown of AMPKα blocked the neuroprotective effects of CT-1 on the expression of AMPAR and mitochondrial/synaptic dysfunction in Aβ-treated mouse neurons. These results suggest that CT-1 may be a potent candidate for the early prevention and treatment of AD.

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Pathological remodeling of myocardium in spontaneous hypertensive rats with experimental diabetes mellitus: the role of mitochondrial dysfunction

Cited by 3 publications

References 36 publications

Features of the Formation of Academic Culture of Future Pianists

Features of the Formation of Academic Culture of Future Pianists

Hyperhomocysteinemia in the pathogenesis of cardiovascular and endocrine diseases: translational messages

The Effects of Cardiotrophin-1 on Early Synaptic Mitochondrial Dysfunction and Synaptic Pathology in APPswe/PS1dE9 Mice

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