Pathological Remodeling of the Gut Barrier as a Prodromal Event of High-Fat Diet-Induced Obesity

D’Antongiovanni, Vanessa; Segnani, Cristina; Ippolito, Chiara; Antonioli, Luca; Colucci, Rocchina; Fornai, Matteo; Bernardini, Nunzia; Pellegrini, Carolina

doi:10.1016/j.labinv.2023.100194

Cited by 6 publications

(1 citation statement)

References 63 publications

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“…149 A recent study by Zhang et al showed that HFD induced the loss of goblet cells and the reduction of mucin 2 (MUC2) expression in the colon of mice, leading to the thinning of the mucus layer and the increased exposure of the epithelium to the luminal contents. 150 TJs consist of various groups of molecules, each serving a different role in maintaining epithelial integrity. For example, Claudins are the main barrier-controlling proteins in TJs.…”

Section: Obesity and Tight Junction Alterationmentioning

confidence: 99%

Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues

AlMarzooqi,

Almarzooqi,

Sadida

et al. 2024

Obesity Reviews

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SummaryObesity stands as a formidable global health challenge, predisposing individuals to a plethora of chronic illnesses such as cardiovascular disease, diabetes, and cancer. A confluence of genetic polymorphisms, suboptimal dietary choices, and sedentary lifestyles significantly contribute to the elevated incidence of obesity. This multifaceted health issue profoundly disrupts homeostatic equilibrium at both organismal and cellular levels, with marked alterations in gut permeability as a salient consequence. The intricate mechanisms underlying these alterations have yet to be fully elucidated. Still, evidence suggests that heightened inflammatory cytokine levels and the remodeling of tight junction (TJ) proteins, particularly claudins, play a pivotal role in the manifestation of epithelial barrier dysfunction in obesity. Strategic targeting of proteins implicated in these pathways and metabolites such as short‐chain fatty acids presents a promising intervention for restoring barrier functionality among individuals with obesity. Nonetheless, recognizing the heterogeneity among affected individuals is paramount; personalized medical interventions or dietary regimens tailored to specific genetic backgrounds and allergy profiles may prove indispensable. This comprehensive review delves into the nexus of obesity, tight junction remodeling, and barrier dysfunction, offering a critical appraisal of potential therapeutic interventions.

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Section: Obesity and Tight Junction Alterationmentioning

confidence: 99%

Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues

AlMarzooqi,

Almarzooqi,

Sadida

et al. 2024

Obesity Reviews

View full text Add to dashboard Cite

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Multivalent MMP-12 inhibitors as a valuable approach to counteract the intestinal epithelial barrier impairment and inflammation in an in vitro model mimicking intestinal high-fat exposure

Cuffaro,

D’Antongiovanni,

Mangini

et al. 2024

Med Chem Res

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Intragastric administration of short chain fatty acids greatly reduces voluntary ethanol intake in rats

Quintanilla,

Santapau,

Diaz

et al. 2024

Sci Rep

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Alcohol use disorder (AUD) represents a public health crisis with few FDA-approved medications for its treatment. Growing evidence supports the key role of the bidirectional communication between the gut microbiota and the central nervous system (CNS) during the initiation and progression of alcohol use disorder. Among the different protective molecules that could mediate this communication, short chain fatty acids (SCFAs) have emerged as attractive candidates, since these gut microbiota-derived molecules have multi-target effects that could normalize several of the functional and structural parameters altered by chronic alcohol abuse. The present study, conducted in male alcohol-preferring UChB rats, shows that the initiation of voluntary ethanol intake was inhibited in 85% by the intragastric administration of a combination of SCFAs (acetate, propionate and butyrate) given before ethanol exposure, while SCFAs administration after two months of ethanol intake induced a 90% reduction in its consumption. These SCFAs therapeutic effects were associated with (1) a significant reduction of ethanol-induced intestinal inflammation and damage; (2) reduction of plasma lipopolysaccharide levels and hepatic inflammation; (3) reduction of ethanol-induced astrocyte and microglia activation; and (4) attenuation of the ethanol-induced gene expression changes within the nucleus accumbens. Finally, we determined that among the different SCFAs evaluated, butyrate was the most potent, reducing chronic ethanol intake in a dose–response manner. These findings support a key role of SCFAs, and especially butyrate, in regulating AUD, providing a simple, inexpensive, and safe approach as a preventive and intervention-based strategy to address this devastating disease. Supplementary Information The online version contains supplementary material available at 10.1038/s41598-024-80228-1.

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Pathological Remodeling of the Gut Barrier as a Prodromal Event of High-Fat Diet-Induced Obesity

Cited by 6 publications

References 63 publications

Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues

Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues

Multivalent MMP-12 inhibitors as a valuable approach to counteract the intestinal epithelial barrier impairment and inflammation in an in vitro model mimicking intestinal high-fat exposure

Intragastric administration of short chain fatty acids greatly reduces voluntary ethanol intake in rats

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