Pathological Rupture of the Spleen Associated With Hepatitis A

Landingham, Samuel B. Van

doi:10.1001/archsurg.1984.01390140080014

Cited by 16 publications

(6 citation statements)

References 3 publications

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“…The majority of atraumatic splenic ruptures (over 90%) are pathologic, which is generally considered to be subsequent to pathological changes in the spleen. 13 A few cases of splenic rupture were previously reported in patients with hepatitisrelated liver cirrhosis and portal hypertension, [3][4][5][6][7] including one rare case of spontaneous rupture of splenic hamartoma which was not encapsulated and composed of sinusoidal spaces and therefore was mostly affected by portal hypertension. 3 In this case, it was apparent that the patient presented portal hypertension and severe splenomegaly due to alcoholic cirrhosis, and the laboratory test upon admission suggested typical hypersplenism.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Liver cirrhosis with splenomegaly and portal hypertension has generally been described as one of the most important pathophysiologic factors that increase the risk of splenic rupture. [3][4][5][6][7] We report a case of atraumatic splenic rupture in a patient with liver cirrhosis associated with splenomegaly and portal hypertension, which was further complicated by intra-cystic haemorrhage and hypersplenism. Anatomic abnormalities in the spleen, such as large splenic cysts, hamartoma, and infarction, are also reportedly associated with splenic rupture.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Atraumatic splenic rupture was attributed to intra-cystic haemorrhage and hypersplenism in a patient with cirrhosis and portal hypertension: A case report

Guan

et al. 2020

SAGE Open Medical Case Reports

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Liver cirrhosis with splenomegaly and portal hypertension has been described in the medical literature as increasing the risk of splenic rupture. We report a case of atraumatic splenic rupture in a male with liver cirrhosis associated with splenomegaly, which was further complicated by hypersplenism and intra-cystic haemorrhage in the spleen. The 56-year-old man was hospitalized because of sudden onset of intermittent pain in the left quadrant abdomen with no history of trauma. Upon admission, the patient presented no fever, palpable abdominal tenderness, splenomegaly, and hypersplenism. Enhanced computed tomography revealed a splenic subcapsular haematoma connected to a cystic mass located at the splenic hilum and free fluid in the abdomen, which is indicative of splenic rupture. The patient underwent immediate laparotomy and splenectomy followed by proper management. Post-surgery diagnostic microscopy indicated liver steatosis, perivenular fibrosis, and regenerative nodules, which are suggestive of cirrhosis. The patient was discharged from the hospital with an uneventful recovery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Atraumatic splenic rupture was attributed to intra-cystic haemorrhage and hypersplenism in a patient with cirrhosis and portal hypertension: A case report

Guan

et al. 2020

SAGE Open Medical Case Reports

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“…However nontraumatic cases in patients with splenomegaly or underlying hematological disorders have been described [ 9 – 11 ]. The most common causes of spontaneous rupture of spleen include infections like Epstein–Barr virus, malaria, human immunodeficiency virus, and hepatitis virus and hematological malignancies like leukemia and lymphoma [ 10 , 12 – 17 ]. Cases of spontaneous rupture in patients with underlying hematological disorders like hemophilia have also been reported [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Sickle Cell Beta-Plus Thalassemia with Subcapsular Hematoma of the Spleen

Dahal

Ghimire

et al. 2017

Case Reports in Hematology

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While splenic complications like hypersplenism, sequestration crisis, and infarction are commonly reported in sickle cell variants like sickle cell beta-plus thalassemia, splenic rupture with hematoma is rare. We present a case of a 32-year-old young male who presented with dull left upper quadrant pain who was found to have multiple subcapsular splenic lacerations and hematoma on abdominal imaging. Hemoglobin electrophoresis confirmed sickle cell beta-plus thalassemia in the patient. There was no history of trauma, and rest of the workup for possible cause of spontaneous rupture of spleen was negative. With the patient refusing splenectomy, he was managed conservatively. Clinicians need to be aware of this rare complication of sickle cell variants.

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“…Small cysts are usually asymptomatic and are found incidentally by imaging techniques. Less often, there is splenomegaly and/or hepatomegaly, lymphadenopathy, abdominal distension, nausea, and vomiting [4][5][6][7][8][9][10][30][31][32][33]. These cysts do not require any further treatment unless the wall is very thin and in danger of rupture.…”

Section: Discussionmentioning

confidence: 99%