Pathology and Natural History of Human Myocarditis

Marboe, Charles C.; Fenoglio, John J.

doi:10.1159/000157119

Cited by 26 publications

(17 citation statements)

References 19 publications

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“…Alternatively, and more commonly, pericarditis develops 2 to 4 weeks after the initial viral infection, when clinical recovery seems to have taken place. 1 This suggests that there may be a bimodal pattern involving mechanisms of direct (viral) and indirect (antibody-mediated) cytotoxicity similar to that seen in cases of myocarditis. Relapsing pericarditis is proposed to be secondary to an autoimmune mechanism, but this is not proved.…”

Section: Patterns and Perplexities In The Pathogenesis Of Viral Periamentioning

confidence: 94%

“…1 The parietal layer is composed of an outer layer rich in fibrous tissue and an inner layer of serous mesothelial cells that apposes an identical serous mesothelial layer, the sole component of the visceral pericardium. This apposition may create a space that contains a small volume of pericardia!…”

Section: Anatomy and Function Of The Pericardium And Myocanliummentioning

confidence: 99%

“…Although the true incidence of acute viral heart disease remains unknown, it is estimated that myocarditis is likely to develop in 5% to 15% of a virusinfected population. 1 Many of those with myocarditis have pericarditis at some point during the illness, although the clinical presentation is usually dominated by one condition or the other.…”

mentioning

confidence: 99%

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Pericarditis and myocarditis

Houghton¹

1992

Postgraduate Medicine

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Pericarditis and myocarditis are inflammatory diseases that are often initiated by common viruses. Pericarditis rarely causes serious long-term disability, whereas myocarditis may lead to chronic congestive cardiomyopathy and permanent disability. The pathogenesis of both is proposed to be bimodal, with an early stage characterized by viral replication and a later stage by infiltration of lymphocytes and necrosis of cells secondary to an autoimmune process. Treatment of pericarditis is usually symptomatic. Myocarditis requires bed rest and conventional therapy for congestive heart failure. Efficacy of immunosuppressive therapy for myocarditis is currently being tested in an international multi-center clinical trial.

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Section: Patterns and Perplexities In The Pathogenesis Of Viral Periamentioning

confidence: 94%

Section: Anatomy and Function Of The Pericardium And Myocanliummentioning

confidence: 99%

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Pericarditis and myocarditis

Houghton¹

1992

Postgraduate Medicine

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“…Sinus tachycardia is more frequent than serious atrial or ventricular arrhythmias, while palpitations secondary to premature atrial or, more often, ventricular premature complexes are common. Ventricular arrhythmias and variable heart blocks are uncommon, but well recognized clinical presentations (Hosenpud et al, 1986;Marboe & Fenoglio et al, 1988). Persistent complex ventricular arrhythmias after apparent resolution of myocarditis were reported in children and young adults as well (Friedman et al, 1994).…”

Section: Arrhythmiasmentioning

confidence: 99%

Clinical Presentation

Fayadh¹

2011

Myocarditis

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“…Numerous viruses may be associated with clinical evidence of myocarditis [66]. The parvovirus B19, enteroviruses, and adenoviruses represent the most commonly identified etiologic agents of human viral cardiomyopathy.…”

Section: Viral Cardiomyopathymentioning

confidence: 99%

Dilated Cardiomyopathies as a Cause of Congestive Heart Failure

Maisch¹,

Ristić²,

Hufnagel³

et al. 2002

Herz

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In recent years, there have been breakthroughs in understanding the molecular and genetic mechanisms involved in this group of conditions, enabling improvement of diagnostic strategies and introduction of new therapies. Ongoing evaluation of antiviral, immunoglobulin, and immunosuppressive therapies including the European Study of Epidemiology and Treatment of Cardiac Inflammatory Diseases (ESETCID), removal of antibodies by immunoadsorption, anticytokine and gene therapy, as well as the mechanical support devices may provide new treatment options.

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Pathology and Natural History of Human Myocarditis

Cited by 26 publications

References 19 publications

Pericarditis and myocarditis

Pericarditis and myocarditis

Clinical Presentation

Dilated Cardiomyopathies as a Cause of Congestive Heart Failure

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