Pathology and pathogenesis of retinal detachment

Ghazi, Nicola G.; Green, W R

doi:10.1038/sj.eye.6700197

Cited by 227 publications

(179 citation statements)

References 93 publications

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“…Cataract surgery is a major risk factor of RRD, due to the high rate of PVD after cataract extraction and a lower hyaluronic acid concentration causing vitreous collapse [21,22]. A previous study found that although only 2.4% of the population underwent cataract surgery, 43% of patients with RRD had a history of cataract extraction [23].…”

Section: Discussionmentioning

confidence: 99%

The Incidence of Rhegmatogenous Retinal Detachment in Kumamoto, Japan between 2009 and 2011

Haga¹,

Kawaji²,

Tsutsumi³

et al. 2017

J Clin Exp Ophthalmol

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Objective: The annual incidence of rhegmatogenous retinal detachment (RRD) in Kumamoto, Japan was previously evaluated in 1990. However, the incidence has not been evaluated during the last 20 years. The purpose of this study was to estimate the current incidence and epidemiologic characteristics of RRD in Kumamoto, Japan. Methods:The study was based on a retrospective chart review of hospital patients living in Kumamoto, Japan. All patients were treated for primary RRD by conventional surgery (pars plana vitrectomy and/or scleral buckling) at Kumamoto University Hospital or Ideta Eye Hospital between January 1, 2009, and December 31, 2011. Information on age, gender, refractive status, and history of cataract surgery was collected.Results: A total of 897 RRD patients were identified during the 3-year study period. The annual incidence of RRD was 16.5 (21.9 in males, 11.7 in females) per 100,000 people, with a peak incidence of 35.4 in the 50-59 years of age group. The incidence of RRD in males was 1.88 times (95% confidence interval, 1.56-2.29) higher than in females (P<0.0001). Prior cataract extraction was found in 14% of RRD eyes. Myopia (≤ −1 diopter [D]) was found in 54%, and high myopia (≤ −6 D) was found in 23%. The mean refraction status was −3.53 ± 3.94 D. The mean refractive status in patients younger than 50 years of age (−6.00 ± 3.33 D) was significantly higher than that in patients 50 years of age or older (−2.23 ± 3.61 D; P<0.001). The incidence of RRD in Kumamoto is expected to increase over the next 20 years in comparison to a previous study investigated in 1990. Conclusion:The annual incidence of RRD was dependent on age, gender, refraction status, and history of cataract surgery. Considering the growing elderly population, we expect that the incidence of RRD will continue to increase in Japan.

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Section: Discussionmentioning

confidence: 99%

The Incidence of Rhegmatogenous Retinal Detachment in Kumamoto, Japan between 2009 and 2011

Haga¹,

Kawaji²,

Tsutsumi³

et al. 2017

J Clin Exp Ophthalmol

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“…It is referred to separation of the neurosensory retina form the underlying retinal pigment epithelium [6]. Clinically, it presents with variable visual loss [7].…”

Section: Discussionmentioning

confidence: 99%

Bilateral Retinal Detachment Secondary to Clomiphene Citrate

Lokaj¹,

Rama²

2018

OJOph

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Purpose: The purpose of this study is to assess the relationship between Clomifene citrate and retinal detachment in particular. Methods: a 42-year-old woman has developed bilateral retinal detachment after three courses of clomiphene citrate. A literature research for bilateral retinal detachment does not include this severe ophthalmologic complication. Conclusion: This is the first reported case of bilateral retinal detachment after treatment with clomiphene citrate. The caution is warranted in treating infertility patients with CC, and patient should be well informed of this side effect before prescribing this therapy by gynecologist.

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“…Silicone oil plays an outstanding role in the management of complex vitreoretinal surgical procedures (12). During silicone oil tamponade, the concentration and release of injected drugs into the posterior segment is unpredictable, however, Bevacizumab injection was found effective for the management of iris neovascularization associated with TRD by several authors (13). Additionally, to the best of our knowledge, the effect of concomitant treatment of silicone oil and bevacizumab after vitrectomy rarely was reported in the literature (14).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Simultaneous Usage of Bevacizumab and Silicone Oil Injection After Vitrectomy in Diabetic Tractional Retinal Detachment

Alishiri¹,

Naderi²,

Jadidi³

et al. 2016

Razavi Int J Med

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Background: Tractional retinal detachment (TRD), a major vision threatening complication, is one of the most common eye emergencies. The most common cause of TRD is proliferative diabetic retinopathy (PDR). The aim of this study was to evaluate the effect of simultaneous usage of bevacizumab and silicone oil injection after vitrectomy for the treatment of diabetic tractional retinal detachment Methods: Twenty five patients (25 eyes) with severe proliferative diabetic retinopathy were recruited into the study. All eyes underwent a single intravitreal injection of bevacizumab 1.25 mg in 0.05 mL along with silicone oil injection after vitrectomy for the management of tractional retinal detachment or vitreous hemorrhage due to severe proliferative diabetic retinopathy. Patients were then scheduled for postoperative clinical examinations at one, three and six months. The main outcome measures were regression of neovascularization, intraocular pressure, visual acuity and retinal reattachment.

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Pathology and pathogenesis of retinal detachment

Cited by 227 publications

References 93 publications

The Incidence of Rhegmatogenous Retinal Detachment in Kumamoto, Japan between 2009 and 2011

The Incidence of Rhegmatogenous Retinal Detachment in Kumamoto, Japan between 2009 and 2011

Bilateral Retinal Detachment Secondary to Clomiphene Citrate

Efficacy of Simultaneous Usage of Bevacizumab and Silicone Oil Injection After Vitrectomy in Diabetic Tractional Retinal Detachment

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