Pathology in Practice

O'Shaughnessy-Hunter, Laura C; Yu, Anthony W.; Goodale, Elizabeth C.; Locke, E.

doi:10.2460/javma.20.06.0358

Cited by 1 publication

(8 citation statements)

References 9 publications

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“…This reflects reported cases in humans 2 and most canine MIS. [10][11][12][13][14][15][16][17]19,24 Conversely to the recent canine CM study, 19 none of our cases showed aggressive histopathology features. This could be incidental due to the small number of biopsies reviewed or biased by our inclusion criteria.…”

Section: Discussionmentioning

confidence: 57%

“…19 The median age at diagnosis in the dogs reported here was 4-years-old, similar to previously described cases of canine CM. 10,[13][14][15][16]18,19,24 However, the age of lesion onset was 2-years-old (range 0.16-11.5) suggesting that the diagnosis of MIS may be delayed in certain cases. Notably, MIS lesions were only reported after 4 years of age in the four dogs with atopic dermatitis.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast with cutaneous and subcutaneous mast cell tumours (MCT), canine CM is rarely reported. Due to this lack of data, the definition of CM is unclear and the distinction between multiple MCTs and CM is challenging both clinically and histopathologically 8–19 . Similarly, SM in dogs is poorly defined and used to describe infiltration of neoplastic mast cells into visceral organs, bone marrow or peripheral blood, and also to describe disseminated metastatic MCT 20–23 ; this latter use was questioned in a recent consensus proposal 8 …”

Section: Introductionmentioning

confidence: 99%

“…Due to this lack of data, the definition of CM is unclear and the distinction between multiple MCTs and CM is challenging both clinically and histopathologically. [8][9][10][11][12][13][14][15][16][17][18][19] Similarly, SM in dogs is poorly defined and used to describe infiltration of neoplastic mast cells into visceral organs, bone marrow or peripheral blood, and also to describe disseminated metastatic MCT [20][21][22][23] ; this latter use was questioned in a recent consensus proposal. 8 Cutaneous mastocytosis is generally a disease of young dogs, clinically characterised by nodules, papules and plaques.…”

mentioning

confidence: 99%

“…However classification of the different clinical subtypes, as reported in humans, does not exist. [10][11][12][13][14][15][16][17][18][19] Histologically, CM presents as diffuse infiltrates of well-differentiated mast cells involving the superficial to deep dermis, [10][11][12][13][14][15][16][17]19,24 resembling low-grade MCTs, 25 although more aggressive features have also been described. 19 Previous studies have investigated several KIT mutations, including exon 8, 9, 11, 17 and 18, in 11 dogs with canine CM and an exon 11 mutation was only documented in one dog.…”

mentioning

confidence: 99%

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Mastocytosis in the skin in dogs: A multicentric case series

Wyatt,

Affolter,

Borio

et al. 2024

Vet Comparative Oncology

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Canine cutaneous mastocytosis (CM) is rare in contrast to canine mast cell tumours. In humans, CM commonly affects children and is usually indolent with possible spontaneous resolution. Systemic mastocytosis (SM) with bone marrow involvement typically affects adults, can have a poor outcome, and often includes skin lesions. ‘Mastocytosis in the skin’ (MIS) is the preferred term of skin lesions, if bone marrow evaluations are not available, which is often the cases in dogs. In human SM and CM, KIT mutations are often detected. The veterinary literature suggests clinical resemblances between human and canine MIS, but data is limited, and KIT mutations are rarely assessed. This retrospective study describes clinicopathological findings, treatment and outcome of 11 dogs with suspected MIS. Dogs with multiple mast cell tumours were excluded. Histopathology reports (n = 5) or slides (n = 6) were reviewed. KIT mutation analysis including exons 8, 9, 11, 14 and 17 were analysed in eight dogs. Median age at diagnosis was 4 years (range, 1–12). Typical clinical signs included multifocal to generalised nodules and papules. Histologically, skin lesions were characterised by dermal infiltration of well‐differentiated mast cells. KIT mutations were detected in 3/8 dogs (exon 9: n = 2; exon 11: n = 1). One dog had mastocytaemia suggesting possible SM. Glucocorticoids were mostly successful with lesion improvement in all treated dogs (n = 8). This cohort highlights resemblances between human and canine MIS. Further studies are required to confirm these findings and establish diagnostic criteria for CM and MIS associated with SM in dogs.

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