Pathology in Practice

Abstract

HistoryA 2-year-old sexually intact male mixed-breed dog was evaluated because of signs of depressed mentation and occasional vomiting and large bowel diarrhea with mucus and frank blood of 1 month' s duration. The dog also had anorexia of 3 days' duration. The dog' s vaccination status was current, and it had no other notable medical history. Clinical, Cytologic, and Gross FindingsOn physical examination, the dog was lethargic; signs of depressed mentation, tachypnea (60 breaths/min), and tachycardia (160 beats/min) were noted. The dog had defecated soft feces admixed with mucus and frank blood in the clinic lobby. During blood sample collection, excessive bleeding occurred at venipuncture sites. A CBC revealed no abnormalities other than mild neutrophilia (11,703 cells/ µL; reference range, 2,060 to 10,600 cells/µL). The automated platelet count was low (50,000 platelets/µL; reference range, 170,000 to 400,000 platelets/µL), but platelet clumps were present; the estimated platelet count was deemed adequate. Serum biochemical abnormalities included azotemia (BUN concentration, 95 mg/dL [reference range, 6 to 25 mg/dL]; creatinine concentration, 5.5 mg/dL [reference range, 0.5 to 1.6 mg/dL]), hypercalcemia (16.7 mg/dL; reference range, 8.9 to 11.4 mg/dL), and hyperphos-

Clinical characteristics and outcome of dogs with presumed primary renal lymphoma

“…Renal involvement in canine multi-centric lymphoma has been previously recognised, typically at advanced tumour stage (Breshears et al 2011). In dogs, the prevalence of primary renal lymphoma, in which the neoplasia originates from the kidneys, unknown in dogs.…”

Urinary Tract

“…Other tumors include fibromas, sarcomas-including hemangiosarcoma, fibrosarcoma, leiomyosarcoma (Sato et al, 2003), and osteosarcoma-and nephroblastoma. Renal lymphoma, a common entity in cats, may represent primary renal disease or be a manifestation of multicentric disease (Breshears et al, 2011;Snead, 2005). Malignant renal epithelial neoplasms often exfoliate well for cytologic evaluation.…”

Bilateral Renal Large B Cell Lymphoma in a Dog: A Case Report and Review of the Literature

“…Canine renal lymphoma is typically secondary and is usually identified as part of multicentric lymphoma [12]. In the veterinary literature, 16 cases of presumed primary renal lymphoma have been reported in dogs 2-9 years of age (Table 1) [1,[12][13][14][15][16][17][18][19][20][21][22][23][24][25]. However, gross and histopathological examination was performed in only nine of them [1,13,16,[18][19][20]22,23,25], while for the rest of the cases the information presented was insufficient to support the diagnosis.…”

“…In the veterinary literature, 16 cases of presumed primary renal lymphoma have been reported in dogs 2-9 years of age (Table 1) [1,[12][13][14][15][16][17][18][19][20][21][22][23][24][25]. However, gross and histopathological examination was performed in only nine of them [1,13,16,[18][19][20]22,23,25], while for the rest of the cases the information presented was insufficient to support the diagnosis. Sometimes lymphoma is reported or implied to be confined to one body system, but in many cases a thorough clinical examination or necropsy has not been performed to determine accurately how confined or not the neoplasm was [2].…”