Pathology of Carcinoma of the Esophagus

Liu, Fu Sheng; Zhou, Chuan Nong

doi:10.1007/978-3-642-69183-6_4

Cited by 5 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adenocarcinoma of the oesophagus remains a heterogenous disease with complex genetic underpinning and is now considered a separate disease 6,7 . Early histological classification systems of oesophageal adenocarcinoma described medullary (ulcerating), fungating (protruding/exophytic) and scirrhous (scarring/stenosing) 8 .…”

Section: Discussionmentioning

confidence: 99%

Endoscopic tumour morphology impacts survival in adenocarcinoma of the oesophagus

Knight¹,

McEwen²,

Byrne

et al. 2020

European Journal of Surgical Oncology

View full text Add to dashboard Cite

Background: Prognostication in oesophageal cancer on the basis of preoperative variables is challenging. Many of the accepted predictors of survival are only derived after surgical treatment and may be influenced by neoadjuvant therapy. This study aims to explore the relationship between pre-treatment endoscopic tumour morphology and postoperative survival.Methods: Patients with endoscopic descriptions of tumours were identified from the prospectively managed databases including the OCCAMS database. Tumours were classified as exophytic, ulcerating or stenosing. Kaplan Meier survival analysis and multivariable Cox regression analyses were performed to determine hazard ratios (HR) with 95% confidence intervals.Results: 262 patients with oesophageal adenocarcinoma undergoing potentially curative resection were pooled from St Thomas' Hospital (161) and the OCCAMS database (101). There were 70 ulcerating, 114 exophytic and 78 stenosing oesophageal adenocarcinomas. Initial tumour staging was similar across all groups (T3/4 tumours 71.4%, 70.2%, 74.4%). Median survival was 55 months, 51 months and 36 months respectively (p<0.001). Rates of lymphovascular invasion (P=0.0176), pathological nodal status (P=0.0195) and pathological T stage (P=0.0007) increased from ulcerating to exophytic to stenosing lesions. Resection margin positivity was 21.4% in ulcerating tumours compared to 54% in stenosing tumours (p<0.001). When compared to stenosing lesions, exophytic and ulcerating lesions demonstrated a significant survival advantage on multivariable analysis (HR 0.56 95% CI 0.31-0.93, HR 0.42 95% CI 0.21-0.82). Conclusion:This study demonstrates that endoscopic morphology may be an important pretreatment prognostic factor in oesophageal cancer. Ulcerating, exophytic and stenosing tumours may represent different pathological processes and tumour biology.

show abstract

Section: Discussionmentioning

confidence: 99%

Endoscopic tumour morphology impacts survival in adenocarcinoma of the oesophagus

Knight¹,

McEwen²,

Byrne

et al. 2020

European Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

Tumours and Tumour‐Like Lesions of the Oesophagus

Day¹,

Jass²,

Price³

et al. 2003

Morson and Dawson's Gastrointestinal Pathology

View full text Add to dashboard Cite

Amplification of the EGF receptor and c‐myc genes in human esophageal cancers

Hsieh

Luo

et al. 1988

Intl Journal of Cancer

124

View full text Add to dashboard Cite

The incidence of esophageal cancer is extremely high in Linxian County and certain other regions of the People's Republic of China. Epidemiologic and laboratory studies suggest that N-nitroso carcinogens and other environmental factors play a causative role. In the present study, employing over 100 DNA samples obtained from Lin-xian patients who underwent surgery for esophageal cancer, we have found a significant frequency of amplification of either the human epidermal growth factor receptor (HER-I) gene or the c-myc oncogene. These changes were found not only in tumor specimens, but also in adjacent non-tumor (grossly normal) tissue specimens obtained from patients with esophageal cancer. RNA samples were also obtained from over 30 tissue samples. These revealed considerable variation in the abundance of HER-I and c-myc transcripts in both the tumor and adjacent non-tumor specimens. A few samples revealed extremely high levels of these transcripts. Thus, changes in gene copy number or level of expression of HER-I or c-myc DNA sequences may play an important role in the pathogenesis of esophageal cancer in this high-risk region.

show abstract

Pathology of Carcinoma of the Esophagus

Cited by 5 publications

References 28 publications

Endoscopic tumour morphology impacts survival in adenocarcinoma of the oesophagus

Endoscopic tumour morphology impacts survival in adenocarcinoma of the oesophagus

Tumours and Tumour‐Like Lesions of the Oesophagus

Amplification of the EGF receptor and c‐myc genes in human esophageal cancers

Contact Info

Product

Resources

About