Pathology of Cardiac Transplantation

Tan, Carmela D.; Halushka, Marc K.; Rodríguez, E. René

doi:10.1016/b978-0-12-420219-1.00016-1

Cited by 9 publications

(16 citation statements)

References 205 publications

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“…Occasional staining of large-vessel endothelium (when present in a biopsy sample), perimyocytes, or sarcolemma may be seen; however, these patterns do not appear to indicate AMR. 27,41 Presence of C3d, a complement split product, is also used to diagnose AMR. 23,38,[42][43][44][45][46] (Figures 1 and 2).…”

Section: Complement Componentsmentioning

confidence: 99%

Antibody-Mediated Rejection in Cardiac Transplantation: Emerging Knowledge in Diagnosis and Management

Colvin¹,

Cook²,

Chang³

et al. 2015

Circulation

287

251

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Section: Complement Componentsmentioning

confidence: 99%

Antibody-Mediated Rejection in Cardiac Transplantation: Emerging Knowledge in Diagnosis and Management

Colvin¹,

Cook²,

Chang³

et al. 2015

Circulation

287

251

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“…The T-cells mediate an inflammatory response which leads to myocyte necrosis and graft failure [10]. Endomyocardial biopsy Corticosteroids, which are not described in the figure, have multiple mechanisms of action that affect both the innate and adaptive immune system.…”

Section: Pathogenesis and Diagnosis Of Acrmentioning

confidence: 98%

“…The antibodies activate the complement system which leads to vessel damage and graft failure [10]. An agreement on the nomenclature of pathologic AMR (pAMR) was published by the ISHLT in 2013 (Table 1b) [15].…”

Section: Pathogenesis and Diagnosis Of Amrmentioning

confidence: 99%

Immunosuppressive therapies after heart transplantation — The balance between under- and over-immunosuppression

Söderlund

Rådegran

2015

Transplantation Reviews

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“…Immunosuppressive patients because of reduced inflamatory response due to immunne suppressive agents. Thus, immunohistochemically staining with appropriate antibodies will be helpful in these cases [46,47]. Pathologic changes especially visible in skin lesions are pseudoepitheliomatous hyperplasia and perivascular lymphohistiocytic infiltration.…”

Section: Immunohistochemistry Of Toxoplasmosismentioning

confidence: 99%

Toxoplasmosis and Public Health Genomics

Oymak¹,

Merve²,

Sevilay³

et al. 2017

Toxoplasmosis

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Toxoplasma gondii infection generally causes flu-like symptoms in healthy individuals; however, immunosuppression of the infected individual causes reactivation of the pathogen to its active form and relapse of the toxoplasmosis. Today it is known that toxoplasmosis triggers psychiatric disorders such as schizophrenia as well as behavioral changes such as suicide attempts. Although dermatological manifestations are very rare, the dermatological lesions are not unique. In addition, previous toxoplasma infection also causes congenital infections because of placental infection and causes birth defects and spontaneous abortion. T. gondii strains are mainly divided into three main clonal lineages, yet higher recombination rate causes unusual population structure and heterogeneous distribution of the pathogen. Both genetic variations, of the pathogen and the patients, are important for virulence property and success of the therapies. The scientist focuses on the genetic variations of the pathogens and individuals to achieve effective treatment and developed tailor-made medicines. Thus, understanding the molecular basis of the disease and the link of molecular mechanism with host immunity is important to fully know the disease and related disorders. In this chapter, we would like to evaluate the current knowledge on genetic, molecular characteristics of toxoplasmosis in view of public health genomics.

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Pathology of Cardiac Transplantation

Cited by 9 publications

References 205 publications

Antibody-Mediated Rejection in Cardiac Transplantation: Emerging Knowledge in Diagnosis and Management

Antibody-Mediated Rejection in Cardiac Transplantation: Emerging Knowledge in Diagnosis and Management

Immunosuppressive therapies after heart transplantation — The balance between under- and over-immunosuppression

Toxoplasmosis and Public Health Genomics

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