Pathology of Chondrosarcoma

Hakim, Muhammad Omar; Rosenberg, Andrew E.

doi:10.1007/978-3-030-74572-1_1

Cited by 2 publications

(2 citation statements)

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“…Some cell nuclei appear enlarged, vesicular, or hyperchromatic. The majority of chondrocytes present themselves as binucleated or multinucleated [16].…”

Section: Morphology and Subtypes Of Chsmentioning

confidence: 99%

Molecular In-Depth Characterization of Chondrosarcoma for Current and Future Targeted Therapies

Walter

Knöll

Eysel

et al. 2023

Cancers

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Chondrosarcoma (CHS) are heterogenous, but as a whole, represent the second most common primary malignant bone tumor entity. Although knowledge on tumor biology has grown exponentially during the past few decades, surgical resection remains the gold standard for the treatment of these tumors, while radiation and differentiated chemotherapy do not result in sufficient cancer control. An in-depth molecular characterization of CHS reveals significant differences compared to tumors of epithelial origin. Genetically, CHS are heterogenous, but there is no characteristic mutation defining CHS, and yet, IDH1 and IDH2 mutations are frequent. Hypovascularization, extracellular matrix composition of collagen, proteoglycans, and hyaluronan create a mechanical barrier for tumor suppressive immune cells. Comparatively low proliferation rates, MDR-1 expression and an acidic tumor microenvironment further limit therapeutic options in CHS. Future advances in CHS therapy depend on the further characterization of CHS, especially the tumor immune microenvironment, for improved and better targeted therapies.

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“…Some cell nuclei appear enlarged, vesicular, or hyperchromatic. The majority of chondrocytes present themselves as binucleated or multinucleated [16].…”

Section: Morphology and Subtypes Of Chsmentioning

confidence: 99%

Molecular In-Depth Characterization of Chondrosarcoma for Current and Future Targeted Therapies

Walter

Knöll

Eysel

et al. 2023

Cancers

View full text Add to dashboard Cite

show abstract

“…CS is classified based on its location as central or peripheral, depending on whether it occurs in the medullary cavity or the articular surface. Histologically, CS encompasses various types, including conventional (the most common), dedifferentiated, clear cell, and mesenchymal variants [ 2 ]. The prognosis and treatment of CS depend on histologic grade and location, making the curettage and resection the first choice.…”

Section: Introductionmentioning

confidence: 99%