Pathology of experimental Trypanosoma evansi infection in rabbits

Uche, U.E.; Jones, T.W.

doi:10.1016/0021-9975(92)90057-2

Cited by 24 publications

(19 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hirokawa et al (1981) also reported mild superficial necrosis of intestinal mucosa in experimental T. musculi infection in mice. T. evansi is highly pathogenic to laboratory animals as observed in the previous studies also (Patel et al 1982;Uche and Jones 1992;Biswas et al 2001Biswas et al , 2010 and in the present study as trypanosomes were observed in stained tissue sections of different visceral organs of mice particularly inside the blood vessels of brain, liver, lung, heart, It was concluded that T. evansi is pathogenic for Swiss albino mice. …”

Section: Intestinesupporting

confidence: 85%

“…3, 4). Congestion, haemorrhages and fatty degeneration of hepatocytes may be due to hypoglycemia leading to starvation of the cells and anoxia due to anaemia in T. evansi infected animals (Srivastava and Ahluwalia 1972;Verma and Gautam 1979;Patel et al 1982;Suryanarayana et al 1986;Uche and Jones 1992;Biswas et al 2001). Consumption of oxygen by trypanosomes for their multiplication lead to hypoxemic state as a result of which animal tissues are deprived of oxygen and it results in degenerative changes in all the vital organs.…”

Section: Livermentioning

confidence: 99%

“…Besides causing ''Surra'' disease in all the principal species of domestic animals (Gill 1991;Misra et al 1976), T. evansi is also highly pathogenic to laboratory animals (rat, mice and rabbit) (Patel et al 1982;Uche and Jones 1992;Biswas et al 2001;Singla et al 2003). The parasite utilizes glucose and oxygen for its growth and multiplication resulting in depletion of these metabolites leading to degenerative changes in the host.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pathological studies on experimental Trypanosoma evansi infection in Swiss albino mice

et al. 2012

View full text Add to dashboard Cite

The pathology of Trypanosoma evansi infection was studied in Swiss albino mice using cattle isolate of the parasite. Sixteen Swiss albino mice were used in the experiment and were divided into two groups viz. infected group (I) and uninfected healthy control group (II) comprising 12 and four mice, respectively. Twelve mice from group I were infected with 1 9 10 5 purified trypanosomes. Systematic necropsy examination specifically of the infected mice (group I) as well as of healthy control (group II) was performed and pathological changes were recorded. The different tissue samples were collected in 10 % neutral buffered formal saline and were used to study the histopathological changes. Gross post-mortem examination revealed enlargement of spleen, petechial haemorrhages in liver in the terminal stages of disease. Tissue sections revealed presence of numerous trypanosomes in blood vessels of liver, spleen, brain and kidneys. Microscopically, liver revealed lesions varying from vacuolar degeneration, coagulative necrosis along with congestion and haemorrhages. Spleen showed extensive haemorrhages in red pulp area, haemosiderosis and aggregation of histiocytes resulting in multinuclear giant cell formation. Lungs revealed oedema, congestion and mild inflammatory changes. Brain revealed mild degenerative changes along with congestion of meningeal blood vessels. Kidneys showed tubular degeneration, congestion and cellular infiltration. Heart revealed mild degenerative changes along with interstitial oedema. All changes were consistent with trypanosome infection and were confirmed by presence of trypanosomes in most of the tissue sections examined.

show abstract

Section: Intestinesupporting

confidence: 85%

Section: Livermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pathological studies on experimental Trypanosoma evansi infection in Swiss albino mice

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Blood flagellates of the genera Leishmania and Trypanosoma have been observed in urine, macrophages of genital mucosa, semen, and the mucous exudate of the penis (Symmers 1960, Hoare 1972, Uche & Jones 1992, Mebrahtu et al 1993). Bloodstream forms of T. cruzi have been observed mixed with sperm (Vianna 1911, Lamano Carvalho et al 1991, in urine (Zeledón 1974), and in almost all urogenital organs of experimental animals (Herrera & Urdaneta-Morales 1992, Lenzi et al 1996.…”

mentioning

confidence: 99%

Experimental transmission of Trypanosoma cruzi through the genitalia of albino mice

Herrera

Urdaneta‐Morales

2001

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

show abstract

“…The basic lesions in the tissues of animals infected by T. evansi are inflammatory (IKEDE et al, 1983;UCHE;JONES, 1992;JUBB;HUXTABLE, 1993;MARQUES, 1996) and are characterized by perivascular cuffing of inflammatory cells, obstruction of capillaries and veins, besides neuronal destruction and demyelinization foci at various degrees (HOLMES, 1987;ANTHOONS et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical characterization of mononuclear cells and MHC II expression in the brain of horses with experimental chronic Trypanosoma evansi infection

Lemos

Marques

Deaquino³

et al. 2007

Rev. Bras. Parasitol. Vet.

View full text Add to dashboard Cite

RESUMOEste estudo objetivou caracterizar a resposta imune celular no sistema nervoso central (SNC) de eqüinos com infecção crônica experimental por Trypanosoma evansi. Para este propósito, foram utilizados os métodos histoquímicos (HE) e imunoistoquímicos do complexo avidina-biotina peroxidase (ABC). O fenótipo do infiltrado celular foi caracterizado com o auxílio de anticorpos anti -CD3, para linfócitos T e anti-BLA36 para linfócitos B. Os macrófagos foram marcados com anticorpo antiantígenos da linhagem mielóide/histiócitos (Clone Mac387). A lesão no sistema nervoso central (SNC) dos eqüinos infectados com T. evansi foi caracterizada como meningoencefalite e meningomielite não supurativa. A gravidade das lesões variou em diferentes segmentos do SNC, refletindo distribuição irregular das alterações vasculares. A distribuição de células T e B e antígenos do complexo maior de histocompatibilidade classe II foram avaliados dentro do SNC de eqüinos cronicamente infectados com T. evansi. O infiltrado perivascular e meníngeo eram constituídos predominantemente por células T e B. Macrófagos foram raramente visualizados. T. evansi não foi identificado no parênquima do SNC dos eqüinos. PALAVRAS-CHAVE:Trypanosoma evansi, tripanossomíases, CMH II, linfócitos T e B, macrófagos. Veterinária, v. 16, n. 4, p. 186-192, 2007. Departamento de Medicina Veterinária, Centro Politécnico, UNICENTRO. Rua Simeão Camargo Varela de Sá, 03, Guarapuava, PR 85040-080, Brasil. E-mail: krlemos@yahoo.com.br An histochemical and immunohistochemical study was carried out to evaluate the mechanisms of immune response of horses experimentally infected by Trypanosoma evansi. For this purpose the HE histochemical stain and the avidin biotin peroxidase method were used. To determine the presence and immunoreactivity of immune cells we used anti-major histocompatibility complex II antibodies. Cellular infiltration fenotype was characterized with the aid of anti-CD3 antibody for T lymphocytes and by anti-BLA 36 antibodies for B lymphocytes. Macrophages were marked with an antibody against myeloid/histyocites antigen (clone Mac387). Lesions in the CNS of experimentally infected horses were those of a wide spread non suppurative encephalomyelitis and meningomyelitis. The severity of lesions varied in different parts of the nervous system, reflecting an irregular distribution of inflammatory vascular changes. Lymphoid perivascular cuffs and meningeal infiltrations were of predominantly composed of T and B cells. The parasite, T. evansi, was not identified in these horses tissues. IMMUNOHISTOCHEMICAL CHARACTERIZATION OF MONONUCLEAR CELLS AND MHC II EXPRESSION IN THE BRAIN OF HORSES WITH EXPERIMENTAL CHRONIC

show abstract

Pathology of experimental Trypanosoma evansi infection in rabbits

Cited by 24 publications

References 12 publications

Pathological studies on experimental Trypanosoma evansi infection in Swiss albino mice

Pathological studies on experimental Trypanosoma evansi infection in Swiss albino mice

Experimental transmission of Trypanosoma cruzi through the genitalia of albino mice

Immunohistochemical characterization of mononuclear cells and MHC II expression in the brain of horses with experimental chronic Trypanosoma evansi infection

Contact Info

Product

Resources

About