2016
DOI: 10.1007/s12105-016-0690-0
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Pathology of Fungal Rhinosinusitis: A Review

Abstract: Fungal rhinosinusitis (FRS) comprises a spectrum of disease processes that vary in clinical presentation, histologic appearances, and biological significance. FRS can be acute or chronic and is most commonly classified as non-invasive or invasive based on whether fungi have invaded into tissue. This manuscript will review the pathologic classification of FRS.

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Cited by 130 publications
(154 citation statements)
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“…Fungal balls of the paranasal sinuses are a non-invasive form of fungal rhinosinusitis, characterized mainly by a unilateral lesion, without involving the underlying mucosa in the inflammatory process. (1) The main clinical manifestations, such as nasal congestion, mucopurulent discharge or bleeding, and headache, are not specific and are found in many diseases of paranasal sinuses. (2) The most informative non-invasive diagnostic methods are computed tomography (CT) and magnetic resonance imaging (MRI).…”
Section: Introductionmentioning
confidence: 99%
“…Fungal balls of the paranasal sinuses are a non-invasive form of fungal rhinosinusitis, characterized mainly by a unilateral lesion, without involving the underlying mucosa in the inflammatory process. (1) The main clinical manifestations, such as nasal congestion, mucopurulent discharge or bleeding, and headache, are not specific and are found in many diseases of paranasal sinuses. (2) The most informative non-invasive diagnostic methods are computed tomography (CT) and magnetic resonance imaging (MRI).…”
Section: Introductionmentioning
confidence: 99%
“…The most aggressive form of fungal sinusitis is AIFS, or fulminant fungal sinusitis , which afflicts severely immunocompromised patients, classically those with hematogenous malignancies or diabetics in ketoacidosis, or those undergoing transplantation . Although there are numerous cases of AIFS occurring in immunocompetent individuals, these individuals often had associated local predisposing trauma such as sinus and root canal surgery .…”
Section: Discussionmentioning
confidence: 99%
“…The differential of the clinical presentation of a yellowish-green nasal discharge and gradual painless proptosis include chronic sino-nasal fungal infection [12] [13]. Although, mycology studies were not carried out on the excised tissue, the histopathological examination did not show typical features suggestive of fungal disease such as the presence of granulomas with refractile fungal hyphae and spores.…”
Section: Discussionmentioning
confidence: 99%