Squamous papillomas are squamous-derived growths commonly arising from the oral cavity and oropharynx. A 75-year-old woman presented with chronic persistent left nasal obstruction and gradual painless non-axial proptosis with loss of vision in the left eye. Computed tomography scan showed an iso-dense lesion filling the frontal, left ethmoidal and sphenoidal sinuses, and the nasal cavity, with extension into the left orbit. She underwent surgical tumor resection with orbital exenteration and histology revealed features of an aggressive hyperkeratotic squamous papilloma arising from the sino-nasal region. Although squamous papillomas have been natively associated with the oral cavity and oropharynx, they present less frequently as sino-nasal tumors with orbital invasion.