Pathology of hyalohyphomycosis caused by Scedosporium apiospermum (Pseudallescheria boydii): An emerging mycosis

Tadros, Talaat S.; Workowski, Kimberly A.; Siegel, Robert J.; Hunter, Steven; Schwartz, David A.

doi:10.1016/s0046-8177(98)90255-6

Cited by 101 publications

(87 citation statements)

References 14 publications

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“…S. prolificans was associated with subcutaneous soft tissue infections with predilections for cartilage and joint areas (93,165,431). Most clinical cases are sporadic and appear in both immunocompetent and immunocompromised individuals.…”

Section: Epidemiology Of Human Infectionsmentioning

confidence: 99%

Infections Caused byScedosporiumspp

et al. 2008

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SUMMARY Scedosporium spp. are increasingly recognized as causes of resistant life-threatening infections in immunocompromised patients. Scedosporium spp. also cause a wide spectrum of conditions, including mycetoma, saprobic involvement and colonization of the airways, sinopulmonary infections, extrapulmonary localized infections, and disseminated infections. Invasive scedosporium infections are also associated with central nervous infection following near-drowning accidents. The most common sites of infection are the lungs, sinuses, bones, joints, eyes, and brain. Scedosporium apiospermum and Scedosporium prolificans are the two principal medically important species of this genus. Pseudallescheria boydii, the teleomorph of S. apiospermum, is recognized by the presence of cleistothecia. Recent advances in molecular taxonomy have advanced the understanding of the genus Scedosporium and have demonstrated a wider range of species than heretofore recognized. Studies of the pathogenesis of and immune response to Scedosporium spp. underscore the importance of innate host defenses in protection against these organisms. Microbiological diagnosis of Scedosporium spp. currently depends upon culture and morphological characterization. Molecular tools for clinical microbiological detection of Scedosporium spp. are currently investigational. Infections caused by S. apiospermum and P. boydii in patients and animals may respond to antifungal triazoles. By comparison, infections caused by S. prolificans seldom respond to medical therapy alone. Surgery and reversal of immunosuppression may be the only effective therapeutic options for infections caused by S. prolificans.

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Section: Epidemiology Of Human Infectionsmentioning

confidence: 99%

Infections Caused byScedosporiumspp

et al. 2008

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“…The noninvasive, colonization infection by S. apiospermum in a preformed 10 or natural 14 air space has been named in the literature as mycetoma 13,15 , fungoma 7 , fungus ball 8,10 , non-aspergillus aspergilloma 5 , and pseudallescherioma 9 . Mycetoma is recognized by tumefaction and draining sinuses, diagnosed by granules.…”

Section: Introductionmentioning

confidence: 99%

Respiratory tract intracavitary colonization due to Scedosporium apiospermum: report of four cases

Severo

Oliveira²,

Irion³

2004

Rev. Inst. Med. trop. S. Paulo

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“…Usually a saprophyte growing in polluted soils and sewage, this filamentous fungus may cause in humans various mycoses resulting from traumatic or iatrogenic inoculation of telluric conidia, including white-grain mycetoma, keratitis, endophthalmitis, osteomyelitis, and endocarditis (15,21,22). Respiratory diseases may also occur in receptive hosts, likely due to the inhalation of airborne conidia, and are similar to those described for A. fumigatus, i.e., unilateral sinusitis, necrotizing pneumonia, fungus ball in the lung, and allergic bronchopulmonary mycosis, as well as disseminated infections in severely immunocompromised hosts.…”

mentioning

confidence: 99%

Genotyping Study of Scedosporium apiospermum Isolates from Patients with Cystic Fibrosis

et al. 2002

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Usually a saprophyte, Scedosporium apiospermum often colonizes the respiratory tracts of patients with cystic fibrosis (CF). In order to improve our understanding of the molecular epidemiology of the airway colonization, 129 sequential and multiple isolates collected from January 1998 to March 1999 from nine CF patients monitored in three hospitals in France were typed by random amplification of polymorphic DNA with primers GC70, UBC-701, and UBC-703. Among these primers, UBC-703 was the most discriminating, allowing the differentiation of 14 genotypes. Combining the results obtained with this three-primer set resulted in the differentiation of 16 genotypes. No common genotype was found among the different patients, and no clustering according to geographic origin of the isolates was seen. In addition, five of the patients were colonized by a single genotype. The others usually exhibited a predominant genotype accompanied by one or two others, which were found occasionally and were genetically close to the predominant genotype. Thus, our study demonstrates the persistence of the fungus despite antifungal treatments and therefore reinforces the need for the development of new antifungals that are more efficient against this species.

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Pathology of hyalohyphomycosis caused by Scedosporium apiospermum (Pseudallescheria boydii): An emerging mycosis

Cited by 101 publications

References 14 publications

Infections Caused byScedosporiumspp

Infections Caused byScedosporiumspp

Respiratory tract intracavitary colonization due to Scedosporium apiospermum: report of four cases

Genotyping Study of Scedosporium apiospermum Isolates from Patients with Cystic Fibrosis

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